scholarly journals Better Islet Function and Cardiovascular Autonomic Function in Chinese Type 2 Diabetic Patients with Pure Small Fiber Neuropathy than with Mixed Neuropathy

2021 ◽  
Author(s):  
Chenxi Li ◽  
Weimin Wang ◽  
Wenyu Ni ◽  
Yu Jin ◽  
Simin Guo ◽  
...  
Keyword(s):  
Autonomic Function ◽  
Small Fiber Neuropathy ◽  
Diabetic Patients ◽  
Islet Function ◽  
Type 2 Diabetic Patients ◽  
Small Fiber ◽  
Cardiovascular Autonomic Function ◽  
Type 2 Diabetic

Impaired autonomic function in type 2 diabetic patients during upper gastrointestinal endoscopy

2008 ◽  
Vol 43 (8) ◽  
pp. 603-608 ◽  
Author(s):  
Akihiro Mori ◽  
Takako Maruyama ◽  
Noritsugu Ohashi ◽  
Takashi Shibuya ◽  
Katsuhisa Sakai ◽  
...  
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Autonomic Function ◽  
Upper Gastrointestinal Endoscopy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Upper Gastrointestinal ◽  
Type 2 Diabetic

Brain natriuretic peptide and cardiac autonomic function in type 2 diabetic patients

2006 ◽  
Vol 72 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Kunio Yufu ◽  
Naohiko Takahashi ◽  
Mikiko Nakagawa ◽  
Masahide Hara ◽  
Tetsunori Saikawa ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Autonomic Function ◽  
Diabetic Patients ◽  
Cardiac Autonomic Function ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Better Islet Function and Cardiovascular Autonomic Function in Type 2 Diabetic Patients With Pure Small Fibre Neuropathy Than With Mixed Neuropathy

2021 ◽  
Author(s):  
Chenxi Li ◽  
Weimin Wang ◽  
Wenyu Ni ◽  
Yu Jin ◽  
Simin Guo ◽  
...  
Keyword(s):  
Autonomic Function ◽  
Common Peroneal Nerve ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Small Fibre Neuropathy ◽  
Cardiovascular Autonomic Function ◽  
Small Fibre ◽  
The Common

Abstract BackgroundThe clinical characteristics and outcomes of small fibre neuropathy (SFN) in Chinese patients with type 2 diabetes have not been thoroughly described, and we investigated metabolic and neurological indexes and the prognosis of type 2 diabetic patients based on skin biopsy. MethodsThirty-four healthy Chinese volunteers were recruited for skin biopsy to establish the reference range of intraepidermal nerve fibre density (IENFD). Eighty-nine patients with type 2 diabetes from the Department of Endocrinology at Nanjing Drum Tower Hospital between December 2015 and April 2020 were included in the final study. Metabolic and neurological indexes were evaluated at baseline. Diabetic cardiovascular autonomic function was tested through cardiovascular autonomic reflex tests (CARTs). Seventeen pure SFN subjects and 9 mixed diabetic polyneuropathy (DPN) subjects were reassessed after the follow-up. ResultsLevels of HbA1c and postprandial blood glucose were lower (P=0.005 and P=0.041, respectively), while postprandial C-peptide and insulin were higher (P=0.001 and P=0.019, respectively) in the pure SFN group than in the mixed DPN group. Regarding the CARTs, the mixed DPN group obtained the highest score, indicating the worst cardiovascular autonomic neuropathy (CAN). Among the four CART items, postural BP change was lower while deep breathing max-min was higher in the pure SFN group than in the mixed DPN group (P=0.023 and P=0.040, respectively). A partial correlation showed that there was a negative correlation between IENFD of the distal leg and CART scores (r=-0.513, P=0.001) after adjusting for age and duration of diabetes. Only vitamin B12 (p=0.028) and motor nerve conduction velocity (MCV) of the common peroneal nerve (p=0.045) were increased in the 17 patients with pure SFN after the follow-up. However, MCVs of the common peroneal nerve (p=0.025) and tibial nerve (p=0.047) were decreased at the final visit in the mixed DPN group. ConclusionsBetter islet function and cardiovascular autonomic function were observed in patients with pure SFN compared with mixed DPN. CART scores were negatively correlated with IENFD in the distal leg even after adjusting for age and duration of diabetes. The metabolic and neurological indexes remained relatively stable in the follow-up of pure SFN subjects.

scholarly journals Cardiovascular responses to tilting in Type 2 Diabetic patients

2020 ◽  
Vol 15 (2) ◽  
pp. 78-84
Author(s):  
Iffat Rejwana ◽  
Sadia Afrin Rimi ◽  
Shamima Sultana ◽  
Sultana Ferdousi
Keyword(s):  
Autonomic Function ◽  
Cardiovascular Response ◽  
Test Group ◽  
Cardiovascular Responses ◽  
Diabetic Patients ◽  
Tilt Table ◽  
Type 2 Diabetic Patients ◽  
Function Test ◽  
Type 2 Diabetic

Background: Diabetes mellitus (DM) is a disorder with a debilitating effects on cardiac autonomic control. Multiple major cardiovascular risk factors associated with DM led diabetic patients at high risk of Cardiovascular Disease. Objective: To assess cardiovascular responses to tilting in Type 2 Diabetic patients (T2DM) with normal and abnormal autonomic function test. Methods: This experimental study was conducted on 60 patients of T2DM. Among them, 30 patients were with normal cardiovascular reflex test (group DN) and 30 patients were with abnormal test (group DA). Thirty(30) apparently healthy subjects with similar age and sex without any physical illness were enrolled as control. Tilt table test of all subjects was done by tilting at 60° for 10 min by using a motorized tilt table. Cardiovascular response to tilt test was assessed by calculating D Heart rate (Acceleration index and Brake index); DSBP (SBP 30s-0 and SBP1 min -0), DDBP (DBP 30s-0 and DBP1 min -0) after tilting. For statistical analysis, one-way ANOVA followed by Bonferroni post hoc was used. Results: In this study, the Acceleration index was significantly higher in patient group DN compared to control and DA(p<0.001). But the Brake index was significantly (p<0.01, p<0.05) lower in both group of patients compared to control. In addition, SBP 30sec-0 and SBP1 min-0 were significantly higher in DA than those of control and DN.DBP 30sec-0 and DBP1min-0 were significantly (p<0.001) lower in DA patients compared to DN and control. Conclusion: This study concluded that cardiovascular response to tilting was weak in T2DM patients and it was greatly affected in T2DM patients with abnormal autonomic function test. J Bangladesh Soc Physiol. 2020, December; 15(2): 78-84

Islet Function and Insulin Sensitivity in the Non-diabetic Offspring of Conjugal Type 2 Diabetic Patients

1990 ◽  
Vol 7 (2) ◽  
pp. 119-125 ◽  
Author(s):  
C. Johnston ◽  
W.K. Ward ◽  
J.C. Beard ◽  
B. McKnight ◽  
D. Porte
Keyword(s):  
Insulin Sensitivity ◽  
Diabetic Patients ◽  
Islet Function ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Effect of essential hypertension on cardiac autonomic function in type 2 diabetic patients

2001 ◽  
Vol 38 (1) ◽  
pp. 232-237 ◽  
Author(s):  
Naohiko Takahashi ◽  
Mikiko Nakagawa ◽  
Tetsunori Saikawa ◽  
Tatsuhiko Ooie ◽  
Kunio Yufu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Autonomic Function ◽  
Diabetic Patients ◽  
Cardiac Autonomic Function ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract #270 Knowledge; Attitude and Practice Among Cambodian Type 2 Diabetic Patients

2018 ◽  
Vol 24 ◽  
pp. 66
Author(s):  
Sum Satha ◽  
Sophanara Min ◽  
Sotharith Bory ◽  
Yom An
Keyword(s):  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Attitude And Practice ◽  
Knowledge Attitude And Practice ◽  
Type 2 Diabetic

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

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