scholarly journals Diagnosis and Management of Alcohol Use Disorder in Patients with Liver Disease: Lights and Shadows

2019 ◽  
Vol 17 (1) ◽  
pp. 127-141 ◽  
Author(s):  
Giovanni Addolorato ◽  
Gabriele A. Vassallo ◽  
Antonio Mirijello ◽  
Antonio Gasbarrini
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Diagnosis And Management

Serum HMGB1 Associates with Liver Disease and Predicts Readmission and Mortality in Patients with Alcohol Use Disorder

Alcohol ◽  
2021 ◽  
Author(s):  
Augustin G.L. Vannier ◽  
Ben Wardwell ◽  
Vladislav Fomin ◽  
Amanda Pebenito ◽  
Nicholas Wolczynski ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder

scholarly journals Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Phillipp Hartmann ◽  
Sonja Lang ◽  
Suling Zeng ◽  
Yi Duan ◽  
Xinlian Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Serum Levels ◽  
Amplicon Sequencing ◽  
Dynamic Changes ◽  
Alcohol Abstinence ◽  
Liver Health ◽  
Fungal Microbiome ◽  
Progressive Liver Disease

BackgroundAlcohol-associated liver disease (ALD) is an important cause of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of ALD; however, little is known about commensal fungi therein.MethodsWe studied the dynamic changes of the intestinal fungal microbiome, or mycobiome, in 66 patients with alcohol use disorder (AUD) and after 2 weeks of alcohol abstinence using internal transcribed spacer 2 (ITS2) amplicon sequencing of fecal samples.ResultsPatients with AUD had significantly increased abundance of the genera Candida, Debaryomyces, Pichia, Kluyveromyces, and Issatchenkia, and of the species Candida albicans and Candida zeylanoides compared with control subjects. Significantly improved liver health markers caspase-cleaved and intact cytokeratin 18 (CK18-M65) levels and controlled attenuation parameter (CAP) in AUD patients after 2 weeks of alcohol abstinence were associated with significantly lower abundance of the genera Candida, Malassezia, Pichia, Kluyveromyces, Issatchenkia, and the species C. albicans and C. zeylanoides. This was mirrored by significantly higher specific anti-C. albicans immunoglobulin G (IgG) and M (IgM) serum levels in AUD patients in relation to control participants, and significantly decreased anti-C. albicans IgG levels in AUD subjects after 2 weeks of abstinence. The intestinal abundance of the genus Malassezia was significantly higher in AUD subjects with progressive liver disease compared with non-progressive liver disease.ConclusionIn conclusion, improved liver health in AUD patients after alcohol abstinence was associated with lower intestinal abundances of Candida and Malassezia, and lower serum anti-C. albicans IgG levels. Intestinal fungi might serve as a therapeutic target to improve the outcome of patients in ALD.

Lifetime drinking history in patients with alcoholic liver disease and patients with alcohol use disorder without liver disease

2017 ◽  
Vol 52 (6-7) ◽  
pp. 762-767 ◽  
Author(s):  
Jon Kristinn Nielsen ◽  
Sigurdur Olafsson ◽  
Ottar M. Bergmann ◽  
Valgerdur Runarsdottir ◽  
Ingunn Hansdottir ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcoholic Liver Disease ◽  
Alcohol Use Disorder ◽  
Drinking History

Executive Functioning Moderates Responses to Appetitive Cues: A Study in Severe Alcohol Use Disorder and Alcoholic Liver Disease

2018 ◽  
Vol 54 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Warren B Logge ◽  
Kirsten C Morley ◽  
Paul S Haber ◽  
Andrew J Baillie
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Executive Functioning ◽  
Alcoholic Liver Disease ◽  
Alcohol Use Disorder ◽  
Appetitive Cues

Confronting the Crisis of Comorbid Alcohol Use Disorder and Alcohol-Related Liver Disease With a Novel Multidisciplinary Clinic

2020 ◽  
Vol 61 (3) ◽  
pp. 238-253
Author(s):  
Gerald Scott Winder ◽  
Anne C. Fernandez ◽  
Kristin Klevering ◽  
Jessica L. Mellinger
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Multidisciplinary Clinic ◽  
Related Liver Disease

scholarly journals N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research

2018 ◽  
Vol 27 (8) ◽  
pp. 667-675 ◽  
Author(s):  
Kirsten C. Morley ◽  
Andrew Baillie ◽  
Wim Van Den Brink ◽  
Kate E. Chitty ◽  
Kathleen Brady ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Acetyl Cysteine

Correlates of liver disease in patients seeking treatment for alcohol use disorder

2017 ◽  
Vol 171 ◽  
pp. e67
Author(s):  
Daniel Fuster ◽  
Arantza Sanvisens ◽  
Paola Zuluaga ◽  
Eva Barluenga ◽  
Inmaculada Rivas ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Alcohol Use Disorder

scholarly journals S1059 Treatment of Alcohol Use Disorder in Patients Admitted with Alcohol-Associated Liver Disease: A Retrospective Cohort Study

2021 ◽  
Vol 116 (1) ◽  
pp. S503-S503
Author(s):  
Patrick Twohig ◽  
Lauren Keim ◽  
Michelle Le ◽  
Nathalie Khoury ◽  
Wuttiporn Manatsathit ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Alcohol Use ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Alcohol Use Disorder
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