Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability

2018 ◽  
Vol 8 (5) ◽  
pp. 1389-1405 ◽  
Author(s):  
Ankit Parikh ◽  
Krishna Kathawala ◽  
Yunmei Song ◽  
Xin-Fu Zhou ◽  
Sanjay Garg
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Dispersion System ◽  
System Part

Development of a rebamipide solid dispersion system with improved dissolution and oral bioavailability

2014 ◽  
Vol 38 (4) ◽  
pp. 522-533 ◽  
Author(s):  
Roshan Pradhan ◽  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Im Soon Choi ◽  
Han-Gon Choi ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Dispersion System

scholarly journals Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System

2015 ◽  
Vol 16 (6) ◽  
pp. 1327-1334 ◽  
Author(s):  
Liandong Hu ◽  
Yanjing Shi ◽  
Jian Heng Li ◽  
Na Gao ◽  
Jing Ji ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Dispersion System

A novel solid dispersion system for natural product-loaded medicine: silymarin-loaded solid dispersion with enhanced oral bioavailability and hepatoprotective activity

2014 ◽  
Vol 31 (7) ◽  
pp. 619-626 ◽  
Author(s):  
Du Hyeong Hwang ◽  
Yong-Il Kim ◽  
Kwan Hyung Cho ◽  
Bijay Kumar Poudel ◽  
Ju Yeon Choi ◽  
...  
Keyword(s):  
Natural Product ◽  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Hepatoprotective Activity ◽  
Dispersion System

Development of a Solid Dispersion System for Improving the Oral Bioavailability of Resveratrol in Rats

2016 ◽  
Vol 42 (2) ◽  
pp. 239-249 ◽  
Author(s):  
Chih-Wei Chang ◽  
Cheng-Yu Wong ◽  
Yu-Tse Wu ◽  
Mei-Chich Hsu
Keyword(s):  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Dispersion System

scholarly journals Development of self-micellizing solid dispersion system employing amphipathic copolymer for the improvement of dissolution and oral bioavailability of cyclosporine A

2016 ◽  
Vol 11 (1) ◽  
pp. 50-51
Author(s):  
Hiroki Suzuki ◽  
Hideyuki Sato ◽  
Yoshiki Kojo ◽  
Takahiro Mizumoto ◽  
Kayo Yuminoki ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Cyclosporine A ◽  
Oral Bioavailability ◽  
Dispersion System

scholarly journals Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 90
Author(s):  
Eun-Sol Ha ◽  
Du Hyung Choi ◽  
In-hwan Baek ◽  
Heejun Park ◽  
Min-Soo Kim
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Pharmaceutical Products ◽  
In Vitro Dissolution ◽  
Dependent Manner ◽  
Amorphous Solid Dispersions ◽  
Eudragit E

In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol. Solid-state characterization of amorphous solid dispersions of trans-resveratrol was performed using powder X-ray diffraction, scanning electron microscopy, and particle size measurements. In addition, an in vitro dissolution study and an in vivo pharmacokinetic study in rats were carried out. Among the tested polymers, Eudragit E/HCl was the most effective solid dispersion for the solubilization of trans-resveratrol. Eudragit E/HCl significantly inhibited the precipitation of trans-resveratrol in a pH 1.2 dissolution medium in a dose-dependent manner. The amorphous Eudragit E/HCl solid dispersion at a trans-resveratrol/polymer ratio of 10/90 exhibited a high degree of supersaturation without trans-resveratrol precipitation for at least 48 h by the formation of Eudragit E/HCl micelles. In rats, the absolute oral bioavailability (F%) of trans-resveratrol from Eudragit E/HCl solid dispersion (10/90) was estimated to be 40%. Therefore, trans-resveratrol-loaded Eudragit E/HCl solid dispersions prepared by spray drying offer a promising formulation strategy with high oral bioavailability for developing high-quality health supplements, nutraceutical, and pharmaceutical products.

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