The present work investigates the tribological properties of AA6061/1.5 wt.% SiC/1.5 wt.% B4C hybrid nanocomposites prepared using stir casting technique. The effect of sliding distance, sliding speed and load were investigated on wear rate (WR) and coefficient of friction (COF). Response surface methodology was used to predict and model the responses. Analysis of variance showed that sliding speed and load were the significant factor affecting WR and COF respectively. Desirability analysis was performed for both single and multi-objective optimization. The minimum WR and COF were found to be 0.0015 mm3/m and 0.2430 at sliding distance of 1939.39 m, sliding speed of 1.99 m/s and load of 10 N.