Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas

2016 ◽  
Vol 363 ◽  
pp. 249-252 ◽  
Author(s):  
Mohammad Reza Boustani ◽  
Reza Jalili Khoshnood ◽  
Fermoozan Nikpasand ◽  
Zabihollah Taleshi ◽  
Koorosh Ahmadi ◽  
...  
Keyword(s):  
Related Factor ◽  
Nuclear Factor ◽  
Human Gliomas ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Protease 2A

scholarly journals Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma

2014 ◽  
Vol 35 (7) ◽  
pp. 1500-1509 ◽  
Author(s):  
Chun-Lin Wang ◽  
Jun-Yu Wang ◽  
Zhen-Yang Liu ◽  
Xiao-Mei Ma ◽  
Xiao-Wen Wang ◽  
...  
Keyword(s):  
Intrinsic Apoptotic Pathway ◽  
Apoptotic Pathway ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Protease 2A

Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-κB

2006 ◽  
Vol 18 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Christos Tzimas ◽  
Gianna Michailidou ◽  
Minas Arsenakis ◽  
Elliott Kieff ◽  
George Mosialos ◽  
...  
Keyword(s):  
Nuclear Factor Κb ◽  
Deubiquitinating Enzyme ◽  
Nuclear Factor ◽  
Human Ubiquitin ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

The ubiquitin-specific protease 8 gene is frequently mutated in adenomas causing Cushing's disease

2015 ◽  
Author(s):  
Luis Gustavo Perez Rivas ◽  
Marily Theodoropoulou ◽  
Francesco Ferrau ◽  
Clara Nusser ◽  
Kohei Kawaguchi ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

Trilobatin Protects Cardiomyocytes from Hypoxia/ Reperfusion Injury by Regulating the Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 133-138
Author(s):  
Wenyu Chen ◽  
Hui He
Keyword(s):  
Heme Oxygenase ◽  
Molecular Mechanisms ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Cellular Injury ◽  
Nuclear Factor ◽  
Oxygen Species ◽  
H9c2 Cells ◽  
Natural Plant ◽  
Induced Changes

Trilobatin is a natural plant-derived glycosylated flavonoid that has been shown to exhibit multiple beneficial pharmacologic activities including protection of heart against H/R-induced cardiomyocyte injury. However, the molecular mechanisms underlying protection from H/R-induced cardiomyocyte injury remain unknown. Using H9C2 cells as a model, we examined the effect of trilobatin on H/R-induced cellular injury, apoptosis, and generation of reactive oxygen species. The results showed that trilobatin protected H9C2 cells not only from cell death and apoptosis, but also counteracted H/R-induced changes in malondialdehyde, superoxide dismutase, glutathione, and glutathione peroxidase. The evaluation of the mechanism underlying the effect of trilobatin on protection from H/R-induced cellular injury suggested changes in the regulation of nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.

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