Insulin-like growth factor-1 in correlation with bone mineral density among Egyptian adolescents with type 1 diabetes mellitus

2011 ◽  
Vol 31 (2) ◽  
pp. 104-112 ◽  
Author(s):  
Eman M. Sherif ◽  
Manal M. Abd Al Aziz ◽  
Nancy S. Elbarbary ◽  
Amal M. Ahmed
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density

scholarly journals A Study of Bone Mineral Density and Its Determinants in Type 1 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ameya Joshi ◽  
Premlata Varthakavi ◽  
Manoj Chadha ◽  
Nikhil Bhagwat
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Type 1 Diabetes ◽  
Growth Factor ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Insulin Like Growth Factor ◽  
Mineral Density

Type 1 diabetes mellitus (T1DM) has been inconsistently associated with low bone mineral density (BMD) and increased fracture risk. 86 consecutive T1DM cases and 140 unrelated age and sex matched healthy nondiabetic controls were included in the study. After history and examination, BMD and body composition were assessed by dual energy X-ray absorptiometry (DXA). Serum samples were analyzed for calcium, phosphorus, albumin, creatinine, alkaline phosphatase, 25 (OH) vitamin D3, intact parathormone (PTH) levels (both cases and controls) and HbA1c, antimicrosomal and IgA tissue transglutaminase (IgA TTG) antibodies, cortisol, follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP3) (cases only). T1DM cases had a lower BMD as compared to controls at both total body (TB) and lumbar spine (LS) (). Patients with celiac autoimmunity (CA) had significantly, lower BMD as compared to age, sex, and body mass index (BMI) matched T1DM controls. Linear regression analysis showed that low BMD in T1DM patients was associated with poor glycaemic control, lower IGF-1 levels, less physical activity (in total population as well as in male and female subgroups), and lower body fat percentage (in females) and higher alkaline phosphatase level (in males) ().

scholarly journals Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

2018 ◽  
Vol 53 (4) ◽  
Author(s):  
Melina Bezerra Loureiro ◽  
Marcela Abbott Galvão Ururahy ◽  
Karla Simone Costa de Souza ◽  
Yonara Monique da Costa Oliveira ◽  
Heglayne Pereira Vital da Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Lower Bone Mineral Density ◽  
Mineral Density

Sclerostin distribution in children and adolescents with type 1 diabetes mellitus and correlation with bone metabolism and bone mineral density

2015 ◽  
Vol 17 (4) ◽  
pp. 289-299 ◽  
Author(s):  
Charalampos Tsentidis ◽  
Dimitrios Gourgiotis ◽  
Lydia Kossiva ◽  
Antonios Marmarinos ◽  
Artemis Doulgeraki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

BONE MINERAL DENSITY AT TIME OF CLINICAL DIAGNOSIS OF ADULT-ONSET TYPE 1 DIABETES MELLITUS

2001 ◽  
Vol 7 (5) ◽  
pp. 346-351 ◽  
Author(s):  
Pablo-José López-Ibarra ◽  
Ma Mar Campos Pastor ◽  
Fernando Escobar-Jiménez ◽  
Ma Dolores Serrano Pardo ◽  
Antonio García González ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Diagnosis ◽  
Bone Mineral ◽  
Adult Onset ◽  
Mineral Density ◽  
Onset Type

Changes in Bone Mineral Density in Young Adults with Type 1 Diabetes Mellitus

2013 ◽  
Vol 20 (3) ◽  
pp. 297-306
Author(s):  
Monica Goia-Socol ◽  
Ileana Duncea ◽  
Gabriela Roman ◽  
Mihai-Andrei Goia-Socol ◽  
Daniel-Corneliu Leucuţa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Young Patients ◽  
Mineral Density

Abstract Background and aims: Type 1 diabetes mellitus (T1DM) represents a secondary cause of osteoporosis. Our aim was to determine bone mineral density (BMD) changes in a group of young Romanian adults with T1DM and to analyze the factors related to this disease that could have had an impact on bone mass. Material and Methods: Fifty-two young patients with T1DM were compared to 37 healthy volunteers matched for body mass index (BMI). All subjects had their BMD measured at the hip and lumbar spine. Results: We found no statistically significant differences in BMD between T1DM patients and controls (p=0.618 for lumbar spine, p=0.974 for femoral neck and p=0.883 for total hip). Multiple linear regression models detected BMI (p =0.043), smoking (p=0.001) and milk intake (p=0.004 for lumbar spine) as significant BMD determinants. In contrast, no associations were found between BMD and metabolic control, daily insulin dose or presence of diabetic retinopathy and/or neuropathy. Long diabetes duration was negatively associated with BMD in femoral neck (p=0.012). Conclusions: Although we couldn’t find differences between BMD in T1DM patients and controls, the link between diabetes duration and BMD that we found suggests that even young patients with long standing T1DM should have their BMD measured

scholarly journals Ex-situ analysis of bone mineral density and cellular activity in type 1 diabetes mellitus

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100485
Author(s):  
Liang-Yu Ma ◽  
Eva Maria Wölfel ◽  
Kilian Elias Stockhausen ◽  
Herbert Mushumba ◽  
Birgit Wulff ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Ex Situ ◽  
Cellular Activity ◽  
Mineral Density

Bone mineral density in children and young adults with Type 1 diabetes mellitus

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S287
Author(s):  
V. Kusec ◽  
N. Rojnic-Putarek ◽  
J. Ille ◽  
A. Radica ◽  
Z. Jurasinovic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Mineral Density ◽  
Children And Young Adults
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