Type 2 diabetes and FTO rs9939609 gene polymorphism: a study among the two tribal population groups of Manipur, North East India

2018 ◽  
Vol 39 (1) ◽  
pp. 60-65
Author(s):  
Somorjit Singh Ningombam ◽  
Sunanda Rajkumari ◽  
Varhlun Chhungi ◽  
Masan Kambo Newmei ◽  
Naorem Kiranmala Devi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Tribal Population ◽  
Population Groups ◽  
North East India ◽  
North East ◽  
Fto Rs9939609

scholarly journals Association of ACE I/D Gene Polymorphism and Related Risk Factors in Impaired Fasting Glucose and Type 2 Diabetes: A Study Among Two Tribal Populations of North-East India.

2021 ◽  
Author(s):  
SUNANDA RAJKUMARI ◽  
SOMORJIT SINGH NINGOMBAM ◽  
VARHLUN CHHUNGI ◽  
MASAN KAMBO NEWMEI ◽  
NAOREM KIRANMALA DEVI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Health Concern ◽  
Environment Interaction ◽  
Hilly Terrain ◽  
North East India ◽  
Physiological Variables ◽  
North East ◽  
Tribal Populations

Abstract AIMType 2 diabetes is a serious public health concern in India, even the indigenous tribal populations are not felt unaffected. The present study aims to understand the association of major risk factors i.e obesity, hypertension, dyslipidemia, ACE I/D polymorphism with impaired (IFG) and type 2 diabetes (T2D) among two different Mendelian populations of North East India. METHODDemographic, somatometric and physiological variables along with fasting blood samples were collected from 609 individuals. ACE I/D polymorphism was screened. RESULTACE I/D polymorphism was found to follow HWE among Liangmai tribe but not among Mizo tribe. Distribution of DD genotype/D allele was found to be significantly higher for T2D among Mizo (OR 2.10; 95% CI 1.10-4.39, OR 2.10;1.16-4.09 respectively ).Significant association between DD genotype/D allele of ACE I/D polymorphism and TC in both IFG (OR 2.22; 95% CI 1.14-4.32) and T2D (OR 2.53;95%CI 1.51-4.23) were observed . LDL was also found to posed significant risk for IFG (OR 2.10;95% CI 1.10-3.91) and T2D (OR 1.04; 95%CI 1.02-1.06). CONCLUSIONThe present study is an example of gene-environment interaction where DD genotype or D allele and dyslipidemia (high TC and high LDL) are posing risk for IFG and T2D both independently and in combination only among Mizo tribe with relatively less physical activity attributed to their residence in less hilly terrain, but Liangmai tribe which resides in high hilly terrain shows no such association.

Association of SLC30A8, CDKAL1, TCF7L2 and HHEX Gene Polymorphisms with Type 2 Diabetes in the Population of North East India

2020 ◽  
Vol 54 (2) ◽  
pp. 165-172
Author(s):  
A. Bhowmick ◽  
P. Sarkar ◽  
M. P. Baruah ◽  
D. Bodhini ◽  
V. Radha ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
North East India ◽  
North East

Correlation between TNF-α- serum level and TNF-α -308 gene polymorphism in Iraqi patients with type 2 diabetes mellitus

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101136
Author(s):  
Sarah Rahman Rasool ◽  
Othman Taha Qasim ◽  
Salaam Khudhur Muslem ◽  
Muataz Mohammed Al-Taee
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Level ◽  
Gene Polymorphism ◽  
Tnf Α

scholarly journals Role of toll like receptor-9 (1237 T/C) gene polymorphism in patients with type 2 diabetes and diabetic foot ulcer

2021 ◽  
Vol 1879 (2) ◽  
pp. 022012
Author(s):  
Furqan Naeem Al-Karawi ◽  
Naji Al-Hasnawiand Abeer Thaher ◽  
Thekra Abd Jebur Al-Kashwan
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Toll Like Receptor
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