scholarly journals Association of ACE I/D gene polymorphism and related risk factors in impaired fasting glucose and type 2 diabetes: a study among two tribal populations of North-East India

2021 ◽  
Author(s):  
Sunanda Rajkumari ◽  
Somorjit Singh Ningombam ◽  
Varhlun Chhungi ◽  
Masan Kambo Newmei ◽  
Naorem Kiranmala Devi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
North East India ◽  
North East ◽  
Related Risk ◽  
Tribal Populations

scholarly journals Association of ACE I/D Gene Polymorphism and Related Risk Factors in Impaired Fasting Glucose and Type 2 Diabetes: A Study Among Two Tribal Populations of North-East India.

2021 ◽  
Author(s):  
SUNANDA RAJKUMARI ◽  
SOMORJIT SINGH NINGOMBAM ◽  
VARHLUN CHHUNGI ◽  
MASAN KAMBO NEWMEI ◽  
NAOREM KIRANMALA DEVI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Health Concern ◽  
Environment Interaction ◽  
Hilly Terrain ◽  
North East India ◽  
Physiological Variables ◽  
North East ◽  
Tribal Populations

Abstract AIMType 2 diabetes is a serious public health concern in India, even the indigenous tribal populations are not felt unaffected. The present study aims to understand the association of major risk factors i.e obesity, hypertension, dyslipidemia, ACE I/D polymorphism with impaired (IFG) and type 2 diabetes (T2D) among two different Mendelian populations of North East India. METHODDemographic, somatometric and physiological variables along with fasting blood samples were collected from 609 individuals. ACE I/D polymorphism was screened. RESULTACE I/D polymorphism was found to follow HWE among Liangmai tribe but not among Mizo tribe. Distribution of DD genotype/D allele was found to be significantly higher for T2D among Mizo (OR 2.10; 95% CI 1.10-4.39, OR 2.10;1.16-4.09 respectively ).Significant association between DD genotype/D allele of ACE I/D polymorphism and TC in both IFG (OR 2.22; 95% CI 1.14-4.32) and T2D (OR 2.53;95%CI 1.51-4.23) were observed . LDL was also found to posed significant risk for IFG (OR 2.10;95% CI 1.10-3.91) and T2D (OR 1.04; 95%CI 1.02-1.06). CONCLUSIONThe present study is an example of gene-environment interaction where DD genotype or D allele and dyslipidemia (high TC and high LDL) are posing risk for IFG and T2D both independently and in combination only among Mizo tribe with relatively less physical activity attributed to their residence in less hilly terrain, but Liangmai tribe which resides in high hilly terrain shows no such association.

Type 2 diabetes and FTO rs9939609 gene polymorphism: a study among the two tribal population groups of Manipur, North East India

2018 ◽  
Vol 39 (1) ◽  
pp. 60-65
Author(s):  
Somorjit Singh Ningombam ◽  
Sunanda Rajkumari ◽  
Varhlun Chhungi ◽  
Masan Kambo Newmei ◽  
Naorem Kiranmala Devi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Tribal Population ◽  
Population Groups ◽  
North East India ◽  
North East ◽  
Fto Rs9939609

scholarly journals Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study

Diabetes Care ◽  
2016 ◽  
Vol 39 (8) ◽  
pp. 1393-1399 ◽  
Author(s):  
Niina Pitkänen ◽  
Markus Juonala ◽  
Tapani Rönnemaa ◽  
Matthew A. Sabin ◽  
Nina Hutri-Kähönen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Impaired Fasting Glucose ◽  
Genetic Risk ◽  
Fasting Glucose ◽  
Childhood Risk Factors ◽  
Young Finns Study

scholarly journals Risk factors of impaired fasting glucose and type 2 diabetes in Yaoundé, Cameroon: a cross sectional study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Clement Nyuyki Kufe ◽  
Kerstin Klipstein-Grobusch ◽  
Fezeu Leopold ◽  
Felix Assah ◽  
George Ngufor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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