Lasiosiphon glaucus a potent ethnobotanical medicinal plant against breast cancer targeting multiple pathways: an invitro study

2022 ◽  
Author(s):  
N. Abhilash ◽  
S. K. Ajay ◽  
K. V. Ramesh ◽  
Renukaradhya K. Math
Keyword(s):  
Breast Cancer ◽  
Medicinal Plant ◽  
Cancer Targeting

Sensitive and Specific Detection of Breast Cancer Lymph Node Metastasis Through Dual-Modality Magnetic Particle Imaging and Fluorescence Molecular Imaging: a Preclinical Evaluation

2021 ◽  
Author(s):  
Guorong Wang ◽  
Guangyuan Shi ◽  
Yu Tian ◽  
Lingyan Kong ◽  
Ning Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Magnetic Particle ◽  
Cancer Targeting ◽  
Node Metastasis ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Fluorescence Molecular Imaging ◽  
Biosafety Evaluation

Abstract Purpose: A sensitive and specific imaging method to detect metastatic cancer cells in lymph nodes (LNs) to detect the early-stage breast cancer is urgently needed. The purpose of this study was to investigate a novel breast cancer-targeting and tumour microenvironment ATP-responsive superparamagnetic iron oxide (SPIOs) imaging probe that was developed to detect lymph node metastasis (LNMs) through fluorescence molecular imaging (FMI) and magnetic particle imaging (MPI). The imaging nanoprobe comprised of SPIOs conjugated with breast cancer-targeting peptides (CREKA) and an ATP-responsive DNA aptamer (dsDNA-Cy5.5), abbreviated as SPIOs@A-T. Methods: SPIOs@A-T was synthesised and characterized for its imaging properties, targeting ability and toxicity in vitro. Mice with metastatic lymph node (MLN) of breast cancer were established to evaluate the FMI and MPI imaging strategy in vivo. Healthy mice with normal lymph node (NLN) were used as control group. Histological examination and biosafety evaluation were performed for further assessment. Results: After injection with SPIO@A-T, the obvious high fluorescent intensity and MPI signal were observed in MLN group than those in NLN group. MPI could also complement the limitation of imaging depth from FMI, thus could detect MLN more sensitively. The combination of the imaging strengths of FMI and MPI ensured the detection of breast cancer metastases with high sensitivity and specificity, thereby facilitating the precision differentiation of malignant from benign LNs. Besides, the biosafety evaluation results showed SPIO@A-T had good biocompatibility. Conclusion: Due to the superior properties of tumour-targeting, detection specificity, and biosafety, the SPIOs@A-T imaging probe in combination with FMI and MPI can provide a promising novel method for the early and precise detection of LNMs in clinical practice.

Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies

2019 ◽  
Vol 93 ◽  
pp. 103332
Author(s):  
Entesar M. Ahmed ◽  
Alaadin E. Sarhan ◽  
Dina H. El-Naggar ◽  
Reham R. Khattab ◽  
Mohamed El-Naggar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Modelling ◽  
Molecular Genetic ◽  
Cancer Targeting ◽  
Molecular Modelling Studies ◽  
Modelling Studies

scholarly journals Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10

2018 ◽  
Vol 78 (6) ◽  
pp. 1404-1417 ◽  
Author(s):  
Adrien Nougarede ◽  
Nikolay Popgeorgiev ◽  
Loay Kassem ◽  
Soleilmane Omarjee ◽  
Stephane Borel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endoplasmic Reticulum ◽  
Cancer Targeting

Abstract 1625: Discovery of a breast cancer targeting peptide with anti-tumor activity

2010 ◽  
Author(s):  
Bettina Proneth ◽  
Wouter H. Driessen ◽  
Amin Hajitou ◽  
Fernanda I. Staquicini ◽  
Wadih Arap ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Targeting ◽  
Targeting Peptide ◽  
Anti Tumor Activity

Roles of FoxM1 in cell regulation and breast cancer targeting therapy

2017 ◽  
Vol 34 (3) ◽  
Author(s):  
Xin Song ◽  
Samuel Selorm Fiati Kenston ◽  
Jinshun Zhao ◽  
Danting Yang ◽  
Yuanliang Gu
Keyword(s):  
Breast Cancer ◽  
Cancer Targeting ◽  
Cell Regulation ◽  
Targeting Therapy

scholarly journals Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects

Theranostics ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 470-484 ◽  
Author(s):  
Wei Tao ◽  
Xiaowei Zeng ◽  
Jun Wu ◽  
Xi Zhu ◽  
Xinghua Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surface Modification ◽  
Cancer Targeting ◽  
Therapeutic Effects
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