Anti-Müllerian Hormone: Current Understanding and Clinical Use

Nucleic acid aptamers in therapeutic anticoagulation

Thrombosis and Haemostasis ◽

10.1160/th04-12-0790 ◽

2005 ◽

Vol 93 (06) ◽

pp. 1014-1020 ◽

Cited By ~ 22

Author(s):

Christopher Rusconi ◽

Bruce Sullenger ◽

Richard Becker

Keyword(s):

Nucleic Acid ◽

Patient Care ◽

Anticoagulant Therapy ◽

Potential Application ◽

Current Understanding ◽

Patient Specific ◽

Clinical Use ◽

Therapeutic Anticoagulation ◽

Prevention And Treatment ◽

Wide Scale

SummaryThe evolution of anticoagulant therapy for the prevention and treatment of thrombotic disorders has progressed at a relatively modest pace considering the scope of the problem and our current understanding of platelet biology, coagulation proteases, and vascular science as they apply to protective haemostasis and pathologic thrombosis. Recent observations, dedicated to cellular-based models of coagulation, provide fundamental constructs, mechanistic clarity, and potentially unparalleled opportunity for accelerating the development and wide-scale clinical use of safe, effective, regulatable and patient-specific therapies. The following review introduces a novel domain of anticoagulant therapy referred to as aptamers (derived from the Latin aptus – to fit), considering their history, development, and potential application in patient care arenas.

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Application of semiconductor and metal nanostructures in biology and medicine

Hematology ◽

10.1182/asheducation-2009.1.701 ◽

2009 ◽

Vol 2009 (1) ◽

pp. 701-707 ◽

Cited By ~ 13

Author(s):

Carl Walkey ◽

Edward A. Sykes ◽

Warren C. W. Chan

Keyword(s):

Contrast Agents ◽

Metallic Nanostructures ◽

Delivery Systems ◽

Current Understanding ◽

Diagnosis And Treatment ◽

Metal Nanostructures ◽

Clinical Use ◽

Nanotechnology Research ◽

Chemical Design ◽

New Generation

Abstract Advances in nanotechnology research have led to the creation of new generation of contrast agents, therapeutics, and delivery systems. These applications are expected to significantly improve the diagnosis and treatment of a variety of diseases. Two nanotechnologies—semiconductor and metallic nanostructures—are the most advanced in this young field and have been extensively investigated for clinical use. These nanostructures are currently the “model” for the developments of many novel nanostructures. This review describes their chemical design, tunable properties, and utility in medicine. Furthermore, we will describe the current understanding of their toxicity, which could be barriers to their use for human.

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Assessing Functional Language in School-Aged Children Using Language Sample Analysis

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00079 ◽

2020 ◽

Vol 5 (3) ◽

pp. 622-636

Author(s):

John Heilmann ◽

Alexander Tucci ◽

Elena Plante ◽

Jon F. Miller

Keyword(s):

Computer Hardware ◽

School Age Children ◽

Functional Language ◽

School Age ◽

Clinical Use ◽

Sample Analysis ◽

Validity And Reliability ◽

Language Sample Analysis ◽

Accuracy And Repeatability ◽

Language Sample

Purpose The goal of this clinical focus article is to illustrate how speech-language pathologists can document the functional language of school-age children using language sample analysis (LSA). Advances in computer hardware and software are detailed making LSA more accessible for clinical use. Method This clinical focus article illustrates how documenting school-age student's communicative functioning is central to comprehensive assessment and how using LSA can meet multiple needs within this assessment. LSA can document students' meaningful participation in their daily life through assessment of their language used during everyday tasks. The many advances in computerized LSA are detailed with a primary focus on the Systematic Analysis of Language Transcripts (Miller & Iglesias, 2019). The LSA process is reviewed detailing the steps necessary for computers to calculate word, morpheme, utterance, and discourse features of functional language. Conclusion These advances in computer technology and software development have made LSA clinically feasible through standardized elicitation and transcription methods that improve accuracy and repeatability. In addition to improved accuracy, validity, and reliability of LSA, databases of typical speakers to document status and automated report writing more than justify the time required. Software now provides many innovations that make LSA simpler and more accessible for clinical use. Supplemental Material https://doi.org/10.23641/asha.12456719

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Translation Research for the Rehabilitation of Left Spatial Neglect and Associated Disorders of Attention in Stroke Patients

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld18.2.55 ◽

2008 ◽

Vol 18 (2) ◽

pp. 55-65 ◽

Cited By ~ 2

Author(s):

Nkiruka Arene ◽

Argye E. Hillis

Keyword(s):

Theoretical Basis ◽

Attention Bias ◽

Spatial Neglect ◽

Clinical Use ◽

Stroke Patients ◽

Translation Research ◽

Unilateral Neglect ◽

Assessment And Treatment ◽

Sound Theoretical Basis ◽

Review Current

Abstract The syndrome of unilateral neglect, typified by a lateralized attention bias and neglect of contralateral space, is an important cause of morbidity and disability after a stroke. In this review, we discuss the challenges that face researchers attempting to elucidate the mechanisms and effectiveness of rehabilitation treatments. The neglect syndrome is a heterogeneous disorder, and it is not clear which of its symptoms cause ongoing disability. We review current methods of neglect assessment and propose logical approaches to selecting treatments, while acknowledging that further study is still needed before some of these approaches can be translated into routine clinical use. We conclude with systems-level suggestions for hypothesis development that would hopefully form a sound theoretical basis for future approaches to the assessment and treatment of neglect.

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