Aloe vera incorporated biomimetic nanofibrous scaffold: a regenerative approach for skin tissue engineering

2014 ◽  
Vol 23 (3) ◽  
pp. 237-248 ◽  
Author(s):  
S. Suganya ◽  
J. Venugopal ◽  
S. Agnes Mary ◽  
S. Ramakrishna ◽  
B. S. Lakshmi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Aloe Vera ◽  
Nanofibrous Scaffold ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Regenerative Approach

Wrinkle-Free, Sandwich, Electrospun PLGA/SF Nanofibrous Scaffold for Skin Tissue Engineering

2018 ◽  
Vol 17 (4) ◽  
pp. 675-679 ◽  
Author(s):  
Caihong Zhu ◽  
Junhui Zhu ◽  
Chengwei Wang ◽  
Ruihua Chen ◽  
Lining Sun ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Nanofibrous Scaffold ◽  
Skin Tissue ◽  
Skin Tissue Engineering

Fabrication and characterization of a collagen coated electrospun poly(3-hydroxybutyric acid)–gelatin nanofibrous scaffold as a soft bio-mimetic material for skin tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 7914-7922 ◽  
Author(s):  
Giriprasath Ramanathan ◽  
Sivakumar Singaravelu ◽  
M. D. Raja ◽  
Naveen Nagiah ◽  
P. Padmapriya ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Application ◽  
Nanofibrous Scaffold ◽  
Skin Tissue ◽  
Tissue Engineering Application ◽  
Hydroxybutyric Acid ◽  
Skin Tissue Engineering ◽  
Promising Tool ◽  
Good Biocompatibility

The collagen coated nanofibrous scaffold mimics the function of the extra cellular matrix with good biocompatibility, cell adhesion, cell proliferation and aids to provide as a promising tool in skin tissue engineering application.

Fabrication of chitosan/poly(caprolactone) nanofibrous scaffold for bone and skin tissue engineering

2011 ◽  
Vol 48 (4) ◽  
pp. 571-576 ◽  
Author(s):  
K.T. Shalumon ◽  
K.H. Anulekha ◽  
K.P. Chennazhi ◽  
H. Tamura ◽  
S.V. Nair ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Nanofibrous Scaffold ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Poly Caprolactone

scholarly journals In VitroBiological Evaluation of Electrospun Polycaprolactone/Gelatine Nanofibrous Scaffold for Tissue Engineering

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Mim Mim Lim ◽  
Tao Sun ◽  
Naznin Sultana
Keyword(s):  
Tissue Engineering ◽  
Cell Attachment ◽  
Fibre Diameter ◽  
Nanofibrous Scaffold ◽  
Skin Tissue ◽  
Engineering Applications ◽  
Electrospinning Technique ◽  
Cell Culture Study ◽  
Skin Tissue Engineering

The fabrication of biocompatible and biodegradable scaffolds which mimic the native extracellular matrix of tissues to promote cell adhesion and growth is emphasized recently. Many polymers have been utilized in scaffold fabrication, but there is still a need to fabricate hydrophilic nanosized fibrous scaffolds with an appropriate degradation rate for skin tissue engineering applications. In this study, nanofibrous scaffolds of a biodegradable synthetic polymer, polycaprolactone (PCL), and blends of PCL with a natural polymer, gelatine (Ge), in three different compositions: 85 : 15, 70 : 30, and 50 : 50 were fabricated via an electrospinning technique. The nanofibrous scaffold prepared from 14% w/v PCL/Ge (70 : 30) exhibited more balanced properties of homogeneous nanofibres with an average fibre diameter of 155.60 ± 41.13 nm, 83% porosity, and surface roughness of 176.27 ± 2.53 nm.In vitrocell culture study using human skin fibroblasts (HSF) demonstrated improved cell attachment with a flattened morphology on the PCL/Ge (70 : 30) nanofibrous scaffold and accelerated proliferation on day 3 compared to the PCL nanofibrous scaffold. These results show that the PCL/Ge (70 : 30) nanofibrous scaffold was more favourable and has the potential to be a promising scaffold for skin tissue engineering applications.

FABRICATION AND CHARACTERIZATION OF ELECTROSPUN PLLA/COLLAGEN NANOFIBROUS SCAFFOLD COATED WITH CHITOSAN TO SUSTAIN RELEASE OF ALOE VERA GEL FOR SKIN TISSUE ENGINEERING

2016 ◽  
Vol 28 (05) ◽  
pp. 1650035 ◽  
Author(s):  
Majid Salehi ◽  
Saeed Farzamfar ◽  
Farshid Bastami ◽  
Roksana Tajerian
Keyword(s):  
Tissue Engineering ◽  
Sustained Release ◽  
Aloe Vera ◽  
Water Vapor Permeability ◽  
Skin Tissue ◽  
Vapor Permeability ◽  
Mouse Fibroblasts ◽  
Skin Tissue Engineering ◽  
Aloe Vera Gel ◽  
Sustain Release

Background and aim: Healing of fire-induced wounds has been still a challenge in clinical issues. The aim of this study was to fabricate a nanofibrous poly (L-lactic acid)/collagen (PLLA/COL) scaffold with sustained release of aloe vera (AV) gel using a chitosan (CT)-coated layer for skin tissue engineering applications. Material and methods: Morphology, porosity, tensile strength, hydrophilicity, degradation rate, water vapor permeability and water uptake ratio of the scaffold were characterized. The behaviors of mouse fibroblasts (L929) were evaluated on the scaffold. Results: We observed that although the porosity of the scaffold was decreased, other characteristics were enhanced by coating a CT layer. The scaffold supports attachment, viability and proliferation of mouse fibroblasts. Conclusion: Consequently, the PLLA/COL scaffold coated with CT for sustained release of AV gel can be considered as a desirable scaffold for skin tissue engineering.

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

2021 ◽  
Author(s):  
Varuna Naga Venkata Arjun Uppuluri ◽  
Shanmugarajan Thukani Sathanantham ◽  
Sai Krishna Bhimavarapu ◽  
Lokesh Elumalai
Keyword(s):  
Tissue Engineering ◽  
Effective Rate ◽  
The Body ◽  
Skin Tissue ◽  
The Novel ◽  
Hydrogel Scaffolds ◽  
Skin Tissue Engineering ◽  
Polymeric Hydrogel ◽  
Regenerative Approach ◽  
Tissue Defects

Tissue engineering is a novel regenerative approach in the medicinal field that promises the regeneration of damaged tissues. Moreover, tissue engineering involves synthetic and natural biomaterials that facilitate tissue or organ growth outside the body. Not surprisingly, the demand for polymer-based therapeutical approaches in skin tissue defects has increased at an effective rate, despite the pressing clinical need. Among the 3D scaffolds for tissue engineering and regeneration approaches, hydrogel scaffolds have shown significant importance for their use as 3D cross-linked scaffolds in skin tissue regeneration due to their ideal moisture retention property and porosity biocompatibility, biodegradable, and biomimetic characteristics. In this review, we demonstrated the choice of ideal biomaterials to fabricate the novel hydrogel scaffolds for skin tissue engineering. After a short introduction to the bioactive and drug-loaded polymeric hydrogels, the discussion turns to fabrication and characterisation techniques of the polymeric hydrogel scaffolds. In conclusion, we discuss the excellent wound healing potential of stem cell-loaded hydrogels and Nano-based approaches to designing hydrogel scaffolds for skin tissue engineering.

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