Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of Inhaled Once-Daily Umeclidinium in Healthy Adults Deficient in CYP2D6 Activity: A Double-Blind, Randomized Clinical Trial

2013 ◽  
Vol 33 (9) ◽  
pp. 653-664 ◽  
Author(s):  
Anthony Cahn ◽  
Rashmi Mehta ◽  
Andrew Preece ◽  
James Blowers ◽  
Alison Donald
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Healthy Adults ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Double Blind ◽  
Cyp2d6 Activity ◽  
Once Daily

A Double-Blind Clinical Comparison of Two Dosage Schedules of Cefatrizine in Children

1988 ◽  
Vol 16 (3) ◽  
pp. 197-200
Author(s):  
P. Careddu ◽  
G. Ceccarelli
Keyword(s):  
Clinical Trial ◽  
Respiratory Tract ◽  
Bacterial Infection ◽  
Randomized Clinical Trial ◽  
Clinical Symptoms ◽  
Daily Administration ◽  
Bacterial Eradication ◽  
Double Blind ◽  
Once Daily ◽  
Clinical Comparison

A double-blind, randomized clinical trial was carried out to compare the effectiveness of twice daily versus once daily administration of the cephalosporin, cefatrizine, in paediatric outpatients with bacterial infection of the respiratory tract. Thirty children were studied, aged 7 years 2 months (range, 4–-12 years). They were given 75 mg/kg·day cefatrizine either once daily or twice daily at 12 h intervals for 8 days. Fever, clinical symptoms, bacterial eradication and overall tolerance were evaluated. No significant differences were observed between once daily or twice daily administration. This is in agreement with other studies carried out on adults. It is concluded that cefatrizine may be given to paediatric out-patients for the treatment of bacterial infection of the respiratory tract only once daily with good clinical and overall results.

Development of a Single-Shot Live-Attenuated Chikungunya Vaccine: A Phase 1 Randomized Clinical Trial in Healthy Adults

2019 ◽  
Author(s):  
Nina Wressnigg ◽  
Romana Hochreiter ◽  
Oliver Zoihsl ◽  
Andrea Fritzer ◽  
Nicole Bézay ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Phase 1 ◽  
Healthy Adults ◽  
Single Shot
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