Reply to Thorborg et al.: High Risk of Bias and Low Transparency in “How Effective are F-MARC Injury Prevention Programs for Soccer Players? A Systematic Review and Meta-Analysis”

2015 ◽  
Vol 46 (2) ◽  
pp. 295-296 ◽  
Author(s):  
Wesam Saleh A. Al Attar ◽  
Najeebullah Soomro ◽  
Evangelos Pappas ◽  
Peter J. Sinclair ◽  
Ross H. Sanders
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Prevention Programs ◽  
Risk Of Bias ◽  
Soccer Players

High Risk of Bias and Low Transparency in “How Effective are F-MARC Injury Prevention Programs for Soccer Players? A Systematic Review and Meta-Analysis”

2015 ◽  
Vol 46 (2) ◽  
pp. 293-294 ◽  
Author(s):  
Kristian Thorborg ◽  
Kasper Krommes ◽  
Ernest Esteve ◽  
Mikkel Bek Clausen ◽  
Else Marie Bartels ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Prevention Programs ◽  
Risk Of Bias ◽  
Soccer Players

How Effective are F-MARC Injury Prevention Programs for Soccer Players? A Systematic Review and Meta-Analysis

2015 ◽  
Vol 46 (2) ◽  
pp. 205-217 ◽  
Author(s):  
Wesam Saleh A. Al Attar ◽  
Najeebullah Soomro ◽  
Evangelos Pappas ◽  
Peter J. Sinclair ◽  
Ross H. Sanders
Keyword(s):  
Systematic Review ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Prevention Programs ◽  
Soccer Players

P-7 Effect of injury prevention programs that include the nordic hamstring exercise on hamstring injury rates in soccer players: a systematic review with meta-analysis

2016 ◽  
Vol 50 (Suppl 1) ◽  
pp. A35.2-A35
Author(s):  
Wesam Saleh A Al Attar ◽  
Najeebullah Soomro ◽  
Peter J Sinclair ◽  
Evangelos Pappas ◽  
Ross H Sanders
Keyword(s):  
Systematic Review ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Prevention Programs ◽  
Soccer Players ◽  
Hamstring Injury ◽  
Injury Rates

How effective are F-MARC injury prevention programs for soccer players? A systematic review and meta-analysis

2015 ◽  
Vol 19 ◽  
pp. e71 ◽  
Author(s):  
W. Al Attar ◽  
N. Soomro ◽  
P. Sinclair ◽  
E. Pappas ◽  
R. Sanders
Keyword(s):  
Systematic Review ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Prevention Programs ◽  
Soccer Players

Effect of Injury Prevention Programs that Include the Nordic Hamstring Exercise on Hamstring Injury Rates in Soccer Players: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 47 (5) ◽  
pp. 907-916 ◽  
Author(s):  
Wesam Saleh A. Al Attar ◽  
Najeebullah Soomro ◽  
Peter J. Sinclair ◽  
Evangelos Pappas ◽  
Ross H. Sanders
Keyword(s):  
Systematic Review ◽  
Injury Prevention ◽  
Meta Analysis ◽  
Prevention Programs ◽  
Soccer Players ◽  
Hamstring Injury ◽  
Injury Rates

scholarly journals Rapid diagnostic test for antenatal syphilis screening in low-income and middle-income countries: a systematic review and meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e018132 ◽  
Author(s):  
Carmen Phang Romero Casas ◽  
Marrissa Martyn-St James ◽  
Jean Hamilton ◽  
Daniel S Marinho ◽  
Rodolfo Castro ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Diagnostic Accuracy ◽  
Pregnant Women ◽  
Sensitivity And Specificity ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Antenatal Clinics

ObjectivesTo undertake a systematic review and meta-analysis to evaluate the test performance including sensitivity and specificity of rapid immunochromatographic syphilis (ICS) point-of-care (POC) tests at antenatal clinics compared with reference standard tests (non-treponemal (TP) and TP tests) for active syphilis in pregnant women.MethodsFive electronic databases were searched (PubMed, EMBASE, CRD, Cochrane Library and LILACS) to March 2016 for diagnostic accuracy studies of ICS test and standard reference tests for syphilis in pregnant women. Methodological quality was assessed using QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies). A bivariate meta-analysis was undertaken to generate pooled estimates of diagnostic parameters. Results were presented using a coupled forest plot of sensitivity and specificity and a scatter plot.ResultsThe methodological quality of the five included studies with regards to risk of bias and applicability concern judgements was either low or unclear. One study was judged as high risk of bias for patient selection due to exclusion of pregnant women with a previous history of syphilis, and one study was judged at high risk of bias for study flow and timing as not all patients were included in the analysis. Five studies contributed to the meta-analysis, providing a pooled sensitivity and specificity for ICS of 0.85 (95% CrI: 0.73 to 0.92) and 0.98 (95% CrI: 0.95 to 0.99), respectively.ConclusionsThis review and meta-analysis observed that rapid ICS POC tests have a high sensitivity and specificity when performed in pregnant women at antenatal clinics. However, the methodological quality of the existing evidence base should be taken into consideration when interpreting these results.PROSPERO registration numberCRD42016036335.

scholarly journals Risk Prediction Models for Liver Cancer in Adults: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Maomao Cao ◽  
He Li ◽  
Dianqin Sun ◽  
Siyi He ◽  
Yadi Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Liver Cancer ◽  
Risk Prediction ◽  
Prediction Models ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Risk Models ◽  
Risk Prediction Models ◽  
Prediction Risk

Abstract Background Prediction of liver cancer risk is beneficial to define high-risk population of liver cancer and guide clinical decisions. We aimed to review and critically appraise the quality of existing risk-prediction models for liver cancer. Methods This systematic review followed the guidelines of CHARMS (Checklist for Critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies) and Preferred Reporting Items for Systematic Reviews and Meta (PRISMA). We searched for PubMed, Embase, Web of Science, and the Cochrane Library from inception to July 2020. Prediction model Risk Of Bias Assessment Tool was used to assess the risk of bias of all potential articles. A narrative description and meta-analysis were conducted. Results After removal irrespective and duplicated citations, 20 risk prediction publications were finally included. Within the 20 studies, 15 studies performed model derivation and validation process, three publications only conducted developed procedure without validation and two articles were used to validate existing models. Discrimination was expressed as area under curve or C statistic, which was acceptable for most models, ranging from 0.64 to 0.96. Calibration of the predictions model were rarely assessed. All models were graded at high risk of bias. The risk bias of applicability in 13 studies was considered low. Conclusions This systematic review gives an overall review of the prediction risk models for liver cancer, pointing out several methodological issues in their development. No prediction risk models were recommended due to the high risk of bias.Systematic review registration: This systematic has been registered in PROSPERO (International Prospective Register of Systemic Review: CRD42020203244).

scholarly journals Do continuous forms of intra-operative ultrafiltration enhance recovery after adult cardiac surgery with cardiopulmonary bypass? A protocol for systematic review and meta-analysis of randomized controlled trials

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Joel Bierer ◽  
David Horne ◽  
Roger Stanzel ◽  
Mark Henderson ◽  
Leah Boulos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
High Risk ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Inflammatory Syndrome ◽  
Adult Cardiac Surgery

Abstract Background Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a systemic inflammatory syndrome that adversely impacts cardiopulmonary function and can contribute to prolonged postoperative recovery. Intra-operative ultrafiltration during CPB is a strategy developed by pediatric cardiac specialists, aiming to dampen the inflammatory syndrome by removing circulating cytokines and improving coagulation profiles during the cardiac operation. Although ultrafiltration is commonly used in the pediatric population, it is not routinely used in the adult population. This study aims to evaluate if randomized evidence supports the use of continuous intra-operative ultrafiltration to enhance recovery for adults undergoing cardiac surgery with CPB. Methods This systematic review and meta-analysis will include randomized controlled trials (RCT) that feature continuous forms of ultrafiltration during adult cardiac surgery with CPB, specifically assessing for benefit in mortality rates, invasive ventilation time and intensive care unit length of stay (ICU LOS). Relevant RCTs will be retrieved from databases, including MEDLINE, Embase, CENTRAL and Scopus, by a pre-defined search strategy. Search results will be screened for inclusion and exclusion criteria by two independent persons with consensus. Selected RCTs will have study demographics and outcome data extracted by two independent persons and transferred into RevMan. Risk of bias will be independently assessed by the Revised Cochrane Risk-of-Bias (RoB2) tool and studies rated as low-, some-, or high- risk of bias. Meta-analyses will compare the intervention of continuous ultrafiltration against comparators in terms of mortality, ventilation time, ICU LOS, and renal failure. Heterogeneity will be measured by the χ2 test and described by the I2 statistic. A sensitivity analysis will be completed by excluding included studies judged to have a high risk of bias. Summary of findings and certainty of the evidence, determined by the GRADE approach, will display the analysis findings. Discussion The findings of this systematic review and meta-analysis will summarize the evidence to date of continuous forms of ultrafiltration in adult cardiac surgery with CPB, to both inform adult cardiac specialists about this technique and identify critical questions for future research in this subject area. Systematic review registration This systematic review and meta-analysis is registered in PROSPERO CRD42020219309 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020219309). 

Effects of Caffeine Supplementation on Physical Performance of Soccer Players: Systematic Review and Meta-Analysis

2021 ◽  
pp. 194173812199871
Author(s):  
Raphael Einsfeld Simões Ferreira ◽  
Rafael Leite Pacheco ◽  
Carolina de Oliveira Cruz Latorraca ◽  
Rachel Riera ◽  
Ricardo Guilherme Eid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Methodological Quality ◽  
Perceived Exertion ◽  
Randomized Clinical Trials ◽  
Data Extraction ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Rating Of Perceived Exertion ◽  
Soccer Players ◽  
Meta Analyses

Context: Caffeine is 1 of the most popular supplements consumed by athletes, and the evidence for improving soccer performance remains limited. Objective: To investigate and update the effects (benefits and harms) of caffeine to improve performance on soccer players. Data Sources: Electronic search in Medline (via PubMed), CENTRAL, Embase, SPORTDiscus, and LILACS, from inception to March 28, 2020. Study Selection: Randomized clinical trials (RCTs) assessing the effects of caffeine on the performance of soccer players. Study Design: Systematic review with meta-analysis. Level of Evidence: Level 1. Data Extraction: Data extraction was conducted independently by 2 authors using a piloted form. We assessed methodological quality (Cochrane risk-of-bias [RoB] table) and the certainty of the evidence (GRADE [Grading of Recommendations Assessment, Development and Evaluation] approach). Results: Sixteen RCTs were included. Overall methodological quality was classified as unclear to low risk of bias. When assessing aerobic endurance, meta-analyses did not demonstrate the differences between caffeine and placebo (mean difference [MD], 44.9 m; 95% confidence interval [CI], −77.7 to 167.6). Similarly, no difference was observed during time to fatigue test (MD, 169.8 seconds; 95% CI, −71.8 to 411.6). Considering anaerobic power, meta-analyses also did not find differences for vertical jump (MD, 1.01 cm; 95% CI, −0.68 to 2.69) and repeated sprint tests (MD, −0.02 seconds; 95% CI, −0.09 to 0.04), as well as reaction time agility test (MD, 0.02 seconds; 95% CI, −0.01 to 0.04) and rating of perceived exertion (MD, 0.16 points; 95% CI, −0.55 to 0.87). Regarding safety, a few minor adverse events were reported. Based on the GRADE approach, the certainty of this evidence was classified as very low to low. Conclusions: We found no significant improvement in soccer-related performance with caffeine compared with placebo or no intervention. However, caffeine appears to be safe.

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