scholarly journals Is Childhood Maltreatment Associated with Body Image Disturbances in Adulthood? A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Christine Bödicker ◽  
Jonas Reinckens ◽  
Michael Höfler ◽  
Jürgen Hoyer
Keyword(s):  
Body Image ◽  
Childhood Maltreatment ◽  
Meta Analysis ◽  
Clinical Samples ◽  
Body Image Disturbances ◽  
Comprehensive Search ◽  
Meta Regression ◽  
Eligibility Assessment ◽  
Comprehensive Search Strategy

Abstract Purpose We aimed to synthesize the evidence for an association between childhood maltreatment and body image disturbances in adulthood. Information on maltreatment subtypes and mediator variables was included to gain further insights into the mechanisms of the association. In addition, we aimed to examine the role of body image disturbances in the development of negative mental health outcomes associated with childhood maltreatment. Methods Based on a comprehensive search strategy, eligible studies were identified in PubMed, Scopus, and Web of Science. The eligibility assessment was performed by two reviewers, and 132 articles were studied full-text. To reduce heterogeneity, only non-clinical samples were included in the meta-analysis. A meta-regression was computed to examine the influence of maltreatment subtype on body image disturbances. Results Our results provide evidence for a robust association between childhood maltreatment and cognitive-affective body image, both in clinical and community samples. Included studies (N = 40) indicate that body image disturbances are especially pronounced in individuals suffering from Posttraumatic Stress Disorder (PTSD) after childhood maltreatment. The meta-analysis included 12 studies with a total of 15.481 participants, and indicates a small overall effect size (r = 0.21, 95% CI = [0.16, 0.26], p < .001). Meta-regression revealed no significant impact of maltreatment subtype in non-clinical samples. Conclusion Childhood maltreatment should be considered as a distal risk factor for the development of a negative cognitive-affective body image. We argue for future longitudinal studies which allow a better understanding of the pathways linking childhood maltreatment, body image disturbances and associated psychopathology.

Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis

2021 ◽  
pp. postgradmedj-2021-140432
Author(s):  
Yue Chen ◽  
Xingyu Cheng ◽  
Chenyu Sun ◽  
Na Hyun Kim ◽  
Sujatha Kailas ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Oesophageal Cancer ◽  
Search Strategy ◽  
Meta Analysis ◽  
Random Effect ◽  
Registration Number ◽  
Comprehensive Search ◽  
Meta Regression ◽  
Comprehensive Search Strategy ◽  
Reduced Risk

ObjectivesStudies on the association between metformin use and the risk of oesophageal cancer (OC) have generated controversial findings. This updated meta-analysis was conducted to reassess the effects of metformin on OC.MethodsA comprehensive search strategy was conducted to select relevant studies from origination to February 2021. Heterogeneity was evaluated through the Q test and I2 statistics. HRs and 95% CIs were pooled through either random-effect or fixed-effect models. Meta-regression, subgroup analyses, sensitivity analysis and publication bias diagnosis were also performed.ResultsSeven studies with 5 426 343 subjects were included. Metformin use was associated with reduced risk of OC (HR=0.69, 95% CI 0.54 to 0.87, p<0.001). Sensitivity analysis suggested that the results were relatively stable.ConclusionMetformin is associated with a reduced risk of OC. More well-designed studies are still needed to further elaborate on these associations.PROSPERO registration numberCRD42021237127.

scholarly journals Music for anxiety? Meta-analysis of anxiety reduction in non-clinical samples

2017 ◽  
Vol 46 (4) ◽  
pp. 473-487 ◽  
Author(s):  
Yulia Panteleeva ◽  
Grazia Ceschi ◽  
Donald Glowinski ◽  
Delphine S. Courvoisier ◽  
Didier Grandjean
Keyword(s):  
Meta Analysis ◽  
Anxiety Reduction ◽  
Cochrane Library ◽  
Clinical Samples ◽  
Eligibility Criteria ◽  
Research Perspectives ◽  
Great Heterogeneity ◽  
Comprehensive Search ◽  
Underlying Processes

The beneficial influence of listening to music on anxiety states has often been discussed. However, the empirical evidence and theoretical mechanisms underlying these effects remain controversial. The aim of this study is to conduct a meta-analysis of randomized controlled trials on the effects of music on anxiety in healthy individuals. A comprehensive search in the PsycINFO, Cochrane Library, PubMed and Web of Knowledge databases produced 19 articles complying with the eligibility criteria. The main results of the study reveal an overall decrease in self-reported anxiety ( d = −0.30, 95% CI [–0.55, –0.04]); however, the decrease was not significant for psychophysiological signals related to anxiety. Nevertheless, in several cases, listening to music greatly affects blood pressure, cortisol level and heart rate. The great heterogeneity of the studies and the lack of rigorous methodological standards, assessed with CONSORT guidelines, may have biased the results. Thus, listening to music should be cautiously considered as a part of more complex music-based psychological interventions for anxiety regulation. Nonetheless, as discussed in this article, the role of underlying processes (spontaneous memory recollections, mental imagery) must not be neglected. Further research perspectives are discussed.

Systematic review and meta-analysis of Altruistic and Game-playing Love

2020 ◽  
Author(s):  
Hossein Dabiriyan Tehrani ◽  
Sara Yamini
Keyword(s):  
Systematic Review ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Game Playing ◽  
Love Styles ◽  
Collectivistic Culture ◽  
Meta Regression ◽  
Collectivistic Cultures ◽  
The Relationship

This systematic review aimed to find attitudes toward Altruistic and Game-playing love styles across individualistic and collectivistic cultures. Addressing major moderators concerning Altruistic and Game-playing love styles are the secondary objectives of this review. This review included 102 articles comprising samples from 37 countries (N = 41997). The findings of this meta-analysis show that there is a collectivistic and individualistic difference in Game-playing but not in the Altruistic love style. Collectivistic and individualistic cultures, on average, demonstrate the same perception concerning the Altruistic love style, whereas collectivistic culture shows the Game-playing love style more strongly. To explain the role of moderators in key measures, the subgroup analysis and meta-regression show that both Game-playing and Altruistic love styles decline by increasing the length of the relationship. Likewise, having children affects these love styles such that the Altruistic love style is improved, and the Game-playing love style is reduced by the presence of children in families.

scholarly journals Regression Modeling and Meta-Analysis of Diagnostic Accuracy of SNP-Based Pathogenicity Detection Tools for UGT1A1 Gene Mutation

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Fakher Rahim ◽  
Hamid Galehdari ◽  
Javad Mohammadi-asl ◽  
Najmaldin Saki
Keyword(s):  
Meta Analysis ◽  
Genomic Variation ◽  
Missense Mutations ◽  
Suggested Model ◽  
Pathogenicity Prediction ◽  
Mutation Score ◽  
Functional Scores ◽  
Comprehensive Search ◽  
Overall Performance

Aims. This review summarized all available evidence on the accuracy of SNP-based pathogenicity detection tools and introduced regression model based on functional scores, mutation score, and genomic variation degree. Materials and Methods. A comprehensive search was performed to find all mutations related to Crigler-Najjar syndrome. The pathogenicity prediction was done using SNP-based pathogenicity detection tools including SIFT, PHD-SNP, PolyPhen2, fathmm, Provean, and Mutpred. Overall, 59 different SNPs related to missense mutations in the UGT1A1 gene, were reviewed. Results. Comparing the diagnostic OR, our model showed high detection potential (diagnostic OR: 16.71, 95% CI: 3.38–82.69). The highest MCC and ACC belonged to our suggested model (46.8% and 73.3%), followed by SIFT (34.19% and 62.71%). The AUC analysis showed a significance overall performance of our suggested model compared to the selected SNP-based pathogenicity detection tool (P=0.046). Conclusion. Our suggested model is comparable to the well-established SNP-based pathogenicity detection tools that can appropriately reflect the role of a disease-associated SNP in both local and global structures. Although the accuracy of our suggested model is not relatively high, the functional impact of the pathogenic mutations is highlighted at the protein level, which improves the understanding of the molecular basis of mutation pathogenesis.

The role of asthma in caries occurrence – meta-analysis and meta-regression

2018 ◽  
Vol 56 (8) ◽  
pp. 841-852 ◽  
Author(s):  
Bernardo Antonio Agostini ◽  
Kaue Farias Collares ◽  
Francine dos Santos Costa ◽  
Marcos Britto Correa ◽  
Flavio Fernando Demarco
Keyword(s):  
Meta Analysis ◽  
Meta Regression

scholarly journals Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis

2020 ◽  
Vol 11 ◽  
pp. 204062231989930
Author(s):  
Huawei Zhao ◽  
Shan Li ◽  
Meijuan Xie ◽  
Rongrong Chen ◽  
Haimei Lu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bioinformatics Analysis ◽  
Close Association ◽  
Meta Analysis ◽  
Population Based ◽  
Brain Disorders ◽  
Cytokines And Chemokines ◽  
Epileptic Patients ◽  
Comprehensive Search ◽  
Meta Regression

Background: An increasing number of studies support an association between rheumatoid arthritis (RA) and brain disorders. This study aims to determine the association between RA and epilepsy. Methods: A comprehensive search of databases in both English and Chinese was performed. Data from the selected studies were extracted and analyzed independently by two authors. Genes associated with epilepsy and RA were also collected and analyzed. Results: We included six nationwide population based studies ( n = 7,094,113 cases in total) for the meta-analysis. The risk of epilepsy was increased in RA patients [risk ratio (RR) = 1.601; 95% confidence interval (CI): 1.089–2.354; p = 0.017; n = 3,803,535 cases] and children born to mothers with RA (RR = 1.475; 95% CI: 1.333–1.633; p < 0.001, n = 3,290,578 cases). Subgroup analysis and meta-regression showed the RR of epilepsy in RA was negatively correlated with age. Furthermore, we found that 433 identified genes in a coexpression network from the hippocampi of 129 epileptic patients were enriched in the RA and related Kyoto Encyclopedia of Genes and Genomes pathways, while 13 genes (mainly related to inflammatory cytokines and chemokines) were identified as potential key genes bridging the RA and epilepsy. Conclusions: Our study, utilizing meta-analysis and bioinformatical data, highlights a close association between epilepsy and RA. Further studies are still warranted to expand these findings, especially for a population that is exposed to RA during fetal and childhood periods.

scholarly journals Expressivity of Interleukin-8 and Gastric Cancer Prognosis Susceptibility: A Systematic Review and Meta-Analysis

Dose-Response ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 155932582110371
Author(s):  
Zhenzhen Wang ◽  
Yuhan Hou ◽  
Zhen Yao ◽  
Yanyan Zhan ◽  
Wenyue Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Interleukin 8 ◽  
Cancer Prognosis ◽  
Cochrane Library ◽  
Comprehensive Search ◽  
Funnel Plots ◽  
The Relationship ◽  
Significant Publication Bias ◽  
Comprehensive Search Strategy

Background The relationship between interleukin-8 (IL-8) expression and the prognosis of gastric cancer (GC) patients has been reported, but the results are contradictory. Aim To investigate the effect of IL-8 expression on the prognosis of patients with GC. Method A comprehensive search strategy was used to search the PubMed, Web of Science and Cochrane Library databases. The total survival time was analysed using the RevMan 5.4 software. Through extensive search and meta-analysis of relevant studies, studies examining the relationship between IL-8 expression and prognosis in patients with GC were conducted to obtain more accurate estimates. Findings Eight studies (1843 patients) were included. The combined results of all the studies showed that high expression of IL-8 was a risk factor for poor prognosis in patients with GC (hazard ratio (HR): 2.08; 95% CI: 1.81–2.39). Sensitivity analysis suggested that the pooled HR was stable, and omitting a single study did not change the significance of the pooled HR. Funnel plots revealed no significant publication bias in the meta-analysis. Conclusion High IL-8 expression could be a negative prognostic biomarker for patients with GC.

Sign in / Sign up

Export Citation Format

Share Document