Preparation, characterization, and antimicrobial activity of chitosan/gum arabic/polyethylene glycol composite films incorporated with black pepper essential oil and ginger essential oil as potential packaging and wound dressing materials

As wound dressing materials, electrospun nanofibrous scaffolds have a lot of promise. Electrospun nanofibrous scaffolds in combination with ZnO nanoparticles have antimicrobial and antioxidant properties, making electrospinning a successful technique for wound dressings.

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ANTIMICROBIAL PROPERTIES OF RABBIT COLLAGEN GLUE-CHITOSAN BIOMATERIAL LOADED WITH CYMBOPOGON FLEXUOSUS ESSENTIAL OIL

TEXTEH Proceedings ◽

10.35530/tt.2021.46 ◽

2021 ◽

Vol 2021 ◽

pp. 385-390

Author(s):

M. Râpă ◽

M.D. Berechet ◽

C. Gaidău ◽

R.R. Constantinescu ◽

A. Moșuțiu

Keyword(s):

Wound Healing ◽

Essential Oil ◽

Wound Dressing ◽

Antimicrobial Agents ◽

Antimicrobial Properties ◽

Natural Polymers ◽

Cymbopogon Flexuosus ◽

Dressing Materials ◽

Lemongrass Essential Oil ◽

Wound Dressing Materials

One approach to develop innovative antimicrobial wound dressing materials is to use natural polymers loaded with antimicrobial agents. The valorisation of animal proteins as biomaterials with antimicrobial properties is a new concern for development of wound healing. Plant esssential oils (EO) also indicate a potential approach for new wound dressing materials able to replace the synthetic antymicrobial agents. In this paper, plant-polymeric film was prepared by casting film-forming emulsion based on lemongrass (Cymbopogon flexuosus) essential oil/Tween 80 dispersed into rabbit collagen glue hydrolysate– chitosan biomaterial. The effect of biomaterial film composition on Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10536 standard bacteria, and Candida albicans ATCC 10231 pathogenic fungus was studied according to European Pharmacopoeia 10/2020 as compared with biomaterial film without essential oil. The in vitro antibacterial tests against three bacterial strains showed that the rabbit collagen glue hydrolysate–chitosan biomaterial inhibited all the three microorganisms. The rabbit collagen hydrolysate glue-chitosan film loaded with lemongrass essential oil exhibits antimicrobial activity towards tested microorganisms but lower as compared with control. The explanation could be due to the short time of investigation, or maybe some active compounds constituents of EO, which favour the cellular proliferation. Preparation of rabbit collagen glue hydrolysate-chitosan biomaterial loaded with lemongrass essential oil is an environmentally friendly solution, which may contribute to the development of wound healing materials as an alternative to topical antimicrobial agents.

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Starch/hyaluronic acid/sorbitol composite films as potential wound dressing materials that protect against P. Aeruginosa

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10ispl1.1705 ◽

2019 ◽

Vol 10 (SPL1) ◽

Author(s):

R. M. Zaki ◽

K. Ramasamy ◽

R. K. Mishra ◽

A. B. A. Majeed ◽

S. M. Lim

Keyword(s):

Hyaluronic Acid ◽

Bacterial Infection ◽

Wound Dressing ◽

Healing Process ◽

Composite Films ◽

Antibacterial Properties ◽

Wound Healing Process ◽

Protection Against Infection ◽

Dressing Materials ◽

Wound Dressing Materials

Bacterial infection is one of the key challenges to the wound healing process. Ideal wound dressing materials should, therefore, be able to inhibit bacterial infection. The present study evaluated the antibacterial properties of composite films for use as wound dressing materials. The composite films, which were made up of starch, sodium hyaluronic acid (SHA), and sorbitol, were prepared at varying concentrations of hyaluronic acid (25-100mg) by solvent casting method. The composite films were tested against gram-negative Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhimurium as well as gram-positive Staphylococcus aureus for 24 hours by using the disc diffusion assay. Chloramphenicol and ciprofloxacin were included as positive controls. Amongst the tested pathogens, composite films with SHA > 25mg inhibited only P. aeruginosa. It is noteworthy that the antibacterial effect of composite films with SHA > 50mg were comparable to those of chloramphenicol and ciprofloxacin. The present findings implied the possible incorporation of starch/ hyaluronic acid/ sorbitol composite films as part of wound dressing for protection against infection caused by P. aeruginosa.

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