Three-dimensional printing of $$\varvec{\upbeta }$$ β -tricalcium phosphate/calcium silicate composite scaffolds for bone tissue engineering

2018 ◽  
Vol 1 (2) ◽  
pp. 146-156 ◽  
Author(s):  
Yifan Dong ◽  
Haibo Duan ◽  
Naru Zhao ◽  
Xiao Liu ◽  
Yijuan Ma ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Calcium Silicate ◽  
Three Dimensional ◽  
Composite Scaffolds ◽  
Three Dimensional Printing ◽  
Dimensional Printing

scholarly journals Three-Dimensional Printing for Craniofacial Bone Tissue Engineering

2020 ◽  
Vol 26 (23-24) ◽  
pp. 1303-1311 ◽  
Author(s):  
Chen Shen ◽  
Lukasz Witek ◽  
Roberto L. Flores ◽  
Nick Tovar ◽  
Andrea Torroni ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Craniofacial Bone ◽  
Dimensional Printing

Three Dimensional Printing of Titanium for Bone Tissue Engineering Applications: A Preliminary Study

2014 ◽  
Vol 21 ◽  
pp. 101-115 ◽  
Author(s):  
Vipra Guneta ◽  
Jun Kit Wang ◽  
Saeed Maleksaeedi ◽  
Ze Ming He ◽  
Marcus Thien Chong Wong ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Computer Aided Design ◽  
Sintering Temperature ◽  
Three Dimensional ◽  
Patient Specific ◽  
Three Dimensional Printing ◽  
Native Bone ◽  
Dimensional Printing

One of the main goals of bone tissue engineering is the development of scaffolds that mimic both functional and structural properties of native bone itself. This study describes the preliminary work carried out to assess the viability of using three dimensional printing (3DP) technology for the fabrication of porous titanium scaffolds with lowered modulus and improved biocompatibility. 3DP enables the manufacturing of three dimensional (3D) objects with a defined structure directly from a Computer Aided Design (CAD). The overall porosity of the 3D structures is contributed by the presence of both pores-by-process (PBP) and pores-by-design (PBD). This study mainly focuses on the PBP, which are formed during the sintering step as the result of the removal of the binding agent polyvinyl alcohol (PVA). Sintering temperatures of 1250oC, 1350oC and 1370oC were used during the fabrication process. Our results showed that by varying the binder percentage and the sintering temperature, pores with diameters in the range of approximately 17-24 μm could be reproducibly achieved. Other physical properties such as surface roughness, porosity and average pore size were also measured for all sample groups. Results from subsequent cell culture studies using adipose tissue-derived mesenchymal stem cells (ASCs) showed improved attachment, viability and proliferation for the 3DP titanium samples as compared to the two-dimensional (2D) dense titanium samples. Hence, based on our current preliminary studies, 3DP technology can potentially be used to fabricate customized, patient-specific metallic bone implants with lowered modulus. This can effectively help in prevention of stress-shielding, and enhancement of implant fixationin vivo. It is envisioned that an optimized combination of binder percentage and sintering temperature can result in the fabrication of scaffolds with the desired porosity and mechanical properties to fit the intended clinical application.

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

scholarly journals Characterization and osteogenic evaluation of mesoporous magnesium–calcium silicate/polycaprolactone/polybutylene succinate composite scaffolds fabricated by rapid prototyping

RSC Advances ◽  
2018 ◽  
Vol 8 (59) ◽  
pp. 33882-33892 ◽  
Author(s):  
Yun Gyeong Kang ◽  
Jie Wei ◽  
Ji Eun Kim ◽  
Yan Ru Wu ◽  
Eun Jin Lee ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Rapid Prototyping ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Silicate ◽  
Composite Scaffold ◽  
Composite Scaffolds ◽  
Polybutylene Succinate

A new composite scaffold consisting of mesoporous magnesium–calcium silicate (m_MCS), polycaprolactone (PCL), and polybutylene succinate (PBSu) was manufactured by a rapid prototyping technique, for stem cell-based bone tissue engineering.

Preparation and Performance Analysis of Mesh Hydroxyapatite/Sodium Alginate Composite Scaffold

2015 ◽  
Vol 1119 ◽  
pp. 239-244
Author(s):  
Yan Xu ◽  
Jian Pin Zhou ◽  
Zheng Ying Wei ◽  
Li Yan Dang ◽  
Feng Lin Wu
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sodium Alginate ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Artificial Bones ◽  
Key Factor ◽  
And Performance

Scaffolds material is the key factor for bone tissue engineering, and construction of the scaffolds is also an important part. Adopting the biocompatible, biodegradable, hydroxyapatite (HAP) and sodium alginate (SA) as the molding material, using three-dimensional printing technology, choosing cross grid filling paths, we manufactured the artificial bones through self-developed 3D printing equipment. Then we measured and analyzed important parameters of the work, and did composite culture experiment. It can be seen that the prepared artificial bone scaffold has good biocompatibility. The paper provides a reference for the study of bone tissue engineering materials.

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