Natural Antioxidants in New Age-Related Diseases

One of the most prominent age-related changes of retinal pigment epithelium (RPE) is the accumulation of melanolipofuscin granules, which could contribute to oxidative stress in the retina. The purpose of this study was to determine the ability of melanolipofuscin granules from younger and older donors to photogenerate reactive oxygen species, and to examine if natural antioxidants could modify the phototoxic potential of this age pigment. Electron paramagnetic resonance (EPR) oximetry, EPR-spin trapping, and time-resolved detection of near-infrared phosphorescence were employed for measuring photogeneration of superoxide anion and singlet oxygen by melanolipofuscin isolated from younger and older human donors. Phototoxicity mediated by internalized melanolipofuscin granules with and without supplementation with zeaxanthin and α-tocopherol was analyzed in ARPE-19 cells by determining cell survival, oxidation of cellular proteins, organization of the cell cytoskeleton, and the cell specific phagocytic activity. Supplementation with antioxidants reduced aerobic photoreactivity and phototoxicity of melanolipofuscin granules. The effect was particularly noticeable for melanolipofuscin mediated inhibition of the cell phagocytic activity. Antioxidants decreased the extent of melanolipofuscin-dependent oxidation of cellular proteins and disruption of the cell cytoskeleton. Although melanolipofuscin might be involved in chronic phototoxicity of the aging RPE, natural antioxidants could partially ameliorate these harmful effects.

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Exploring of new age-related CpGs using Methbank database and the pyrosequencing

Forensic Science International Genetics Supplement Series ◽

10.1016/j.fsigss.2019.09.102 ◽

2019 ◽

Vol 7 (1) ◽

pp. 266-267

Author(s):

Bowen Xie ◽

Shuangshuang Wang ◽

Mingkun Xie ◽

Haibo Luo ◽

Ke Zhang ◽

...

Keyword(s):

New Age ◽

Age Related

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Social Justice, Health Inequities, and Access to New Age-Related Interventions

Medicine Studies ◽

10.1007/s12376-009-0027-3 ◽

2009 ◽

Vol 1 (3) ◽

pp. 281-295 ◽

Cited By ~ 4

Author(s):

Hans-Jörg Ehni ◽

Georg Marckmann

Keyword(s):

Social Justice ◽

Health Inequities ◽

New Age ◽

Age Related

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Green Tea Extract Suppresses the Age-Related Increase in Collagen Crosslinking and Fluorescent Products in C57BL/6 Mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.73.6.453 ◽

2003 ◽

Vol 73 (6) ◽

pp. 453-460 ◽

Cited By ~ 49

Author(s):

Rutter ◽

Sell ◽

Fraser ◽

Obrenovich ◽

Zito ◽

...

Keyword(s):

Vitamin C ◽

Green Tea ◽

Natural Antioxidants ◽

Green Tea Extract ◽

Carbonyl Stress ◽

Collagen Crosslinking ◽

Antioxidant Mechanism ◽

Age Related ◽

Fluorescent Products ◽

Tea Extract

Collagen crosslinking during aging in part results from Maillard reaction endproducts of glucose and oxoaldehydes. Because of the tight link between oxidative and carbonyl stress, we hypothesized that natural antioxidants and 'nutriceuticals' could block collagen aging in C57BL/6 mice. Six groups of young and adult mice received vitamin C, vitamin E, vitamin C&E, blueberry, green tea extract (GTE), or no treatment for a period of 14 weeks. Body weights and collagen glycation were unaltered by the treatment. However, GTE or vitamin C&E combined blocked tendon crosslinking at 10 months of age (p < 0.05, adult group). GTE also blocked fluorescent products at 385 and 440 nm (p = 0.052 and < 0.05, respectively) and tended to decrease skin pentosidine levels. These results suggest that green tea is able to delay collagen aging by an antioxidant mechanism that is in part duplicated by the combination of vitamin C and E.

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Plant Polyphenols, More than Just Simple Natural Antioxidants: Oxidative Stress, Aging and Age-Related Diseases

Medicines ◽

10.3390/medicines7050026 ◽

2020 ◽

Vol 7 (5) ◽

pp. 26 ◽

Cited By ~ 4

Author(s):

Christophe Hano ◽

Duangjai Tungmunnithum

Keyword(s):

Natural Antioxidants ◽

Extraction Methods ◽

Biological Properties ◽

Modern Medicine ◽

Special Issue ◽

Aging Effects ◽

Plant Polyphenols ◽

Traditional Medicines ◽

Age Related ◽

The Status

The present editorial serves as an introduction to the Special Issue “Antioxidant and Anti-aging Action of Plant Polyphenols”. It also provides a summary of the polyphenols, their biological properties and possible functions as medicines, the importance of traditional medicines as a source of inspiration, the rationalization of new uses of plant extracts which lead to applications in modern medicine, the status of modern green-chemistry extraction methods, and some reflections on future prospects. Here, the articles from this Special Issue, and the main aspects of the antioxidant and anti-aging effects of plant polyphenols are discussed in the form of seven questions.

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Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review

Pharmaceuticals ◽

10.3390/ph15010101 ◽

2022 ◽

Vol 15 (1) ◽

pp. 101

Author(s):

Kah-Hui Wong ◽

Hui-Yin Nam ◽

Sze-Yuen Lew ◽

Murali Naidu ◽

Pamela David ◽

...

Keyword(s):

Macular Degeneration ◽

Vision Loss ◽

Web Of Science ◽

Clinical Care ◽

Natural Antioxidants ◽

Age Related Macular Degeneration ◽

Anatomical Changes ◽

Age Related ◽

Disease Stages ◽

Whole Foods

Age-related macular degeneration (AMD) is a multifactorial disease associated with anatomical changes in the inner retina. Despite tremendous advances in clinical care, there is currently no cure for AMD. This review aims to evaluate the published literature on the therapeutic roles of natural antioxidants in AMD. A literature search of PubMed, Web of Science and Google Scholar for peer-reviewed articles published between 1 January 2011 and 31 October 2021 was undertaken. A total of 82 preclinical and 18 clinical studies were eligible for inclusion in this review. We identified active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins and whole foods with potential therapeutic roles in AMD. We evaluated the integral cellular signaling pathways including the activation of antioxidant pathways and angiogenesis pathways orchestrating their mode of action. In conclusion, we examined the therapeutic roles of natural antioxidants in AMD which warrant further study for application in clinical practice. Our current understanding is that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be the key to preventing irreversible vision loss.

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