Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality worldwide.Sleep-induced hypoxemia is defined as “an SpO2 (oxyhemoglobin saturation) during sleep of <90% for more than five minutes with a nadir of at least 85%” or “> 30% of total sleep time with anSpO2 of < 90%” in subject with a baseline awake SpO2 of ≥ 90%. Patients with moderate or severeCOPD run a high risk of developing SIH mainly because of alveolar hypoventilation and ventilationperfusionmismatch. Compared to their non-SIH brethren, SIH COPD patients have greater degreesof pulmonary hypertension and cor pulmonale, require more frequent hospitalizations, and sustainhigher mortality rates. And the necessity of treatment of isolated SIH in COPD has been debatedfor years. In this mini review, the definition, reasons, prevalence, clinical significance and treatmentapproaches of SIH in COPD are summarized._______________________________________________________________________________________Keywords: chronic obstructive pulmonary disease; polysomnography; rapid eye movement;sleep-induced hypoxemia.
Primary alveolar hypoventilation and XXXXY chromosopathy