Spontaneous preterm birth: A case-control study

1991 ◽  
Vol 165 (5) ◽  
pp. 1290-1296 ◽  
Author(s):  
Ine de Haas ◽  
Bernard L. Harlow ◽  
Daniel W. Cramer ◽  
Fredric D. Frigoletto
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Case Control ◽  
Spontaneous Preterm Birth ◽  
Control Study

scholarly journals Sleep duration, vital exhaustion, and odds of spontaneous preterm birth: a case–control study

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Sandhya Kajeepeta ◽  
Sixto E Sanchez ◽  
Bizu Gelaye ◽  
Chunfang Qiu ◽  
Yasmin V Barrios ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Sleep Duration ◽  
Case Control Study ◽  
Case Control ◽  
Spontaneous Preterm Birth ◽  
Vital Exhaustion ◽  
Control Study

scholarly journals Gut microbial-related metabolite trimethylamine-N-oxide and its precursor L-carnitine are associated with spontaneous preterm birth: a nested case-control study

2019 ◽  
Author(s):  
Xing Chen ◽  
Ning Huang ◽  
Chaoqun Liu ◽  
Yue Chen ◽  
Lulu Huang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Labor ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Maternal Serum ◽  
Spontaneous Preterm Birth ◽  
Nested Case Control ◽  
Related Metabolite ◽  
Control Study

Abstract Background: Gut microbiota has been proven to disease susceptibility and may lead to increased risk of preterm birth. To date, the link of gut microbial-related metabolite trimethylamine-N-oxide (TMAO), L-carnitine, and betaine, with spontaneous preterm birth (sPTB) has not been established. This study aimed to investigate the association of TMAO, L-carnitine and betaine, with sPTB risk. Methods: A nested case-control study was designed including 129 sPTB cases and 258 controls based on Guangxi Birth Cohort Study. TMAO, L-carnitine, and betaine level in maternal serum were determined by liquid chromatography with mass spectrometry. Conditional logistic regression analyses were used to examine the association between maternal serum metabolites and sPTB. Stratified analyses were further conducted according to BMI and preterm prelabor rupture of membranes. Spline analyses were performed to explore the dose-response relationship between the metabolites and sPTB.Results: Statistically significant association with decreased sPTB risk was observed for the highest L-carnitine (OR: 0.47; 95% CI: 0.23, 0.95). In risk analyses stratified by BMI, similar results were observed in normal weight gravida (BMI: 18.5~23.9 kg/cm2). The significant subtype-specific association with TMAO (OR: 0.43; 95% CI: 0.20, 0.93) and L-carnitine (OR: 0.45; 95% CI: 0.21, 0.97) were observed for preterm labor but not PPROM. Spline regression analysis indicated non-linear associations with TMAO and sPTB risk (P for nonlinearity: 0.057). Significant associations of TMAO with sPTB were observed in normal weight gravida (P = 0.028) and preterm labor subtype (P = 0.025). No statistically significant associations with sPTB risk were observed for betaine (P > 0.05).Conclusions: TMAO and L-carnitine levels in maternal serum are inversely linked with sPTB risk. Discovery of the association between gut-microbiota initiated TMAO metabolism and sPTB may open new avenues for diagnose and therapy.

Risk Factors for Spontaneous Preterm Birth: A Northern Italian Multicenter Case-Control Study

2002 ◽  
Vol 53 (3) ◽  
pp. 174-180 ◽  
Author(s):  
Laura Carlini ◽  
Edgardo Somigliana ◽  
Gabriele Rossi ◽  
Fabrizio Veglia ◽  
Mauro Busacca ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Case Control Study ◽  
Case Control ◽  
Spontaneous Preterm Birth ◽  
Control Study

Spontaneous preterm birth: A case-control study

1991 ◽  
Vol 165 (4) ◽  
pp. 1290-1296 ◽  
Author(s):  
Ine de Haas ◽  
Bernard L. Harlow ◽  
Daniel W. Cramer ◽  
Fredric D. Frigoletto
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Case Control ◽  
Spontaneous Preterm Birth ◽  
Control Study

scholarly journals Chlamydia trachomatis lower genital tract infection and spontaneous preterm birth: a case-control study nested in the BRISA cohort

2021 ◽  
Vol 33 ◽  
Author(s):  
Larissa Brito Bastos ◽  
Giulia Karnauchovas Porto Cunha ◽  
Stella Felippe de Freitas ◽  
Ricardo de Carvalho Cavalli ◽  
Silvana Maria Quintana
Keyword(s):  
Preterm Birth ◽  
Chlamydia Trachomatis ◽  
Case Control Study ◽  
Case Control ◽  
Full Term ◽  
Obstetric Outcomes ◽  
Control Group ◽  
Spontaneous Preterm Birth ◽  
Factor Α ◽  
Control Study

Introduction: Chlamydia trachomatis (CT) is a sexually transmitted bacterium that is highly prevalent in young patients. Chlamydial infections during the gestational period have been associated with adverse obstetric outcomes, such as spontaneous preterm birth (sPTB). However, results in the literature are inconclusive. Objective: To evaluate the association between CT infection and sPTB. Methods: This was a case-control study nested in the cohort of the prospective Brazilian Ribeirão Preto and São Luís birth cohort study. Pregnant patients were recruited in private and public health clinics in São Luís and Ribeirão Preto, Brazil. At the gestational age of 20-25 weeks, cervicovaginal fluid samples were collected for the diagnosis of CT using a polymerase chain reaction. Plasma levels of Transforming Growth Factor-α (TGF- α), Interferon-γ (IFN- γ), Interleukin-10 (IL-10), IL-13, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, Tumor Necrosis Factor-α (TNF- α), and TNF-β were measured using a multiplex assay. Results: Of the 561 pregnant patients evaluated, 121 had sPTB and 440 had a full-term delivery (control group). According to our results, CT infection was not associated with sPTB (odds ratio, 1.13; 95% confidence interval, 0.50–2.56); however, it was more frequent among younger patients (p=0.0078), unmarried patients (p=0.0144), and those with multiple sexual partners (p=0.0299). There were no significant differences in the immune mediators between patients with sPTB or full-term deliveries, or between patients with or without a CT infection. Conclusion: In conclusion, CT infection was not associated with sPTB in our study. However, its correlation with younger pregnant patients suggests that these patients require careful clinical management.

Sign in / Sign up

Export Citation Format

Share Document