Clinical studies of liver function the hepatorenal syndrome

An analysis of literature reviews, clinical studies, experimental research, clinical recommendations from pubmed / Medline and ELIBRARY databases on keywords for“liver cirrhosis”and“hepatorenal syndrome”was carried out. In accordance with modern studies, the idea of the pathophysiology of hepatorenal syndrome was revised in recent years, departing from the assumption that the development of this pathology is associated only with renal hypoperphusion due to the development of peripheral systemic arterial vasodilation. Today, the effect of cardiovascular, immune, endocrine systems, coagulation systems, hematological changes, endothelial dysfunction, reception of drugs and other factors for the development of renal dysfunction is studied.

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General: Liver Transplantation

Anesthesiology Applied Exam Board Review ◽

10.1093/med/9780190852474.003.0005 ◽

2018 ◽

pp. 31-38

Author(s):

Frederico Osorio

Keyword(s):

Liver Transplantation ◽

Liver Function ◽

Hepatorenal Syndrome ◽

Postoperative Bleeding ◽

Main Topic ◽

Intraoperative Management ◽

Systemic Manifestations

In this chapter the essential aspects of anesthesia for liver transplantation are reviewed. Subtopics include the systemic manifestations of cirrhosis and their effects on anesthesia planning. Additionally, the hemodynamic consequences of the different stages of liver transplantation—preanhepatic, anhepatic, and reperfusion—are reviewed. The chapter is divided into preoperative, intraoperative, and postoperative sections with important subtopics related to the main topic in each section. Preoperative topics include relevant means of assessing cardiac and liver function status. Ascites and hepatorenal syndrome are also discussed. Issues related to intraoperative management include choice of monitor, hematological considerations, and induction. Postoperative topics discussed are postoperative bleeding, and coagulopathy and anemia.

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Clinical studies of liver function

The American Journal of Surgery ◽

10.1016/s0002-9610(42)90948-6 ◽

1942 ◽

Vol 57 (1) ◽

pp. 43-50 ◽

Cited By ~ 8

Author(s):

C.R. Schmidt ◽

R.T. Unruh ◽

V.E. Chesky

Keyword(s):

Liver Function ◽

Clinical Studies

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Use of drugs in children with impaired liver function

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2020.8.3.0475 ◽

2020 ◽

Vol 8 (3) ◽

pp. 149-153

Author(s):

Muzal Kadim

Keyword(s):

Chronic Hepatitis ◽

Liver Disease ◽

Liver Function ◽

Clinical Studies ◽

The Body ◽

Efficacy And Safety ◽

Pharmacokinetics And Pharmacodynamics ◽

Impaired Liver Function ◽

Liver Disorders ◽

Impaired Liver

Liver disorders in children will affect the pharmacokinetics and pharmacodynamics of drugs that are metabolized in the liver. Chronic liver disease in children such as chronic hepatitis, cirrhosis of the liver can affect the absorption and disposition (pharmacokinetics) of drugs and the efficacy and safety (pharmacodynamics) of drugs in the body. Dosage modification is determined based on clinical studies examining the effects of impaired liver function on the pharmacodynamics and pharmacokinetics of a drug.

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Acetaminophen: Macula densa hypersecretory activity by induced hepatotoxicity

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010012895x ◽

1987 ◽

Vol 45 ◽

pp. 934-935

Author(s):

S.S. Poolsawat ◽

C.A. Huerta ◽

S.TY. Lae ◽

G.A. Miranda

Keyword(s):

Cell Proliferation ◽

Liver Function ◽

Chronic Inflammation ◽

Foam Cell ◽

Term Effect ◽

Short Term ◽

Drug Induced ◽

Experimental Induction ◽

Tissue Alterations ◽

Toxic Responses

Introduction. Experimental induction of altered histology by chemical toxins is of particular importance if its outcome resembles histopathological phenomena. Hepatotoxic drugs and chemicals are agents that can be converted by the liver into various metabolites which consequently evoke toxic responses. Very often, these drugs are intentionally administered to resolve an illness unrelated to liver function. Because of hepatic detoxification, the resulting metabolites are suggested to be integrated into the macromolecular processes of liver function and cause an array of cellular and tissue alterations, such as increased cytoplasmic lysis, centrilobular and localized necroses, chronic inflammation and “foam cell” proliferation of the hepatic sinusoids (1-4).Most experimentally drug-induced toxicity studies have concentrated primarily on the hepatic response, frequently overlooking other physiological phenomena which are directly related to liver function. Categorically, many studies have been short-term effect investigations which seldom have followed up the complications to other tissues and organs when the liver has failed to function normally.

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