Simultaneous determination of unconjugated homovanillic acid, vanilmandelic acid, and 3-methoxy-4-hydroxyphenylethylene glycol, in serum by mass fragmentography and deuterated internal standards

1980 ◽  
Vol 109 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Frits A.J. Muskiet ◽  
Gijs T. Nagel ◽  
Bert G. Wolthers
Keyword(s):  
Simultaneous Determination ◽  
Homovanillic Acid ◽  
Mass Fragmentography ◽  
Internal Standards ◽  
Vanilmandelic Acid

scholarly journals Simultaneous Determination of α-Tocopherol and α-Tocopheryl Acetate in Plasma by Mass Fragmentography

1979 ◽  
Vol 99 (10) ◽  
pp. 1037-1041
Author(s):  
MASASHI NAKANISHI ◽  
KAZUKO TSUCHIYA ◽  
KENYA SAKAGUCHI ◽  
TAKESHI FUJITA
Keyword(s):  
Simultaneous Determination ◽  
Alpha Tocopherol ◽  
Tocopheryl Acetate ◽  
Mass Fragmentography

Determination of 3-methoxy-4-hydroxyphenylpyruvic acid, 3,4-dihydroxyphenylethylene glycol, and 3,4-dihydroxyphenylmandelic acid in urine by mass fragmentography, with use of deuterium-labeled internal standards.

1978 ◽  
Vol 24 (11) ◽  
pp. 2001-2008 ◽  
Author(s):  
F A Muskiet ◽  
D C Fremouw-Ottevangers ◽  
G T Nagel ◽  
B G Wolthers ◽  
J A de Vries
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Mass Fragmentography ◽  
Decarboxylase Inhibitor ◽  
Purification Method ◽  
Internal Standards ◽  
Chromatography Mass Spectrometry ◽  
Catecholamine Metabolites

Abstract We report the determination of 3-methoxy-4-hydroxyphenylpyruvic acid, 3,4-dihydroxyphenylmandelic acid, and 3,4-dihydroxyphenylethylene glycol in urine, by use of gas chromatography/mass spectrometry in combination with a simple purification method and deuterium-labeled internal standards. Normal excretion values in terms of creatinine, expressed as a function of age, are given, together with results obtained for patients with neuroblastoma, pheochromocytoma, or parkinsonism treated with L-DOPA + peripheral decarboxylase inhibitor, and for a patient receiving dopamine. We were unable to identify 3, 4-dihydroxyphenyllactic acid in urine. The results obtained and their relation to other catecholamine metabolites and catecholamine-precursor metabolites in urine are discussed.

Mass-fragmentographic determination of catecholamine metabolites in amniotic fluid and its possible clinical usefulness.

1978 ◽  
Vol 24 (11) ◽  
pp. 1899-1902 ◽  
Author(s):  
F A Muskiet ◽  
H J Jeuring ◽  
G T Nagel ◽  
H W de Bruyn ◽  
B G Wolthers
Keyword(s):  
Amniotic Fluid ◽  
Gestational Age ◽  
Phenylacetic Acid ◽  
Mass Fragmentography ◽  
Absolute Concentration ◽  
Creatinine Concentration ◽  
Internal Standards ◽  
Catecholamine Metabolites ◽  
Congenital Neuroblastoma

Abstract We describe the determination of 3-methoxy-4-hydroxy-phenylacetic acid, 3-methoxy-4-hydroxyphenylamandelic acid, and 3-methoxy-4-hydroxyphenylethylene glycol in amniotic fluid by means of mass fragmentography, with use of deuterated internal standards. The results expressed in terms of absolute concentration and creatinine concentration, are given as a function of gestational age. In the 15th to 17th week, concentrations in amniotic fluid are a reflection of those in the mother's serum, whereas in the 32nd to 40th week, these concentrations, expressed in terms of creatinine, are similar to those found in the urine of newborns. We discuss the possible usefulness of the determination of catecholamine metabolites in amniotic fluid in the diagnosis of congenital neuroblastoma, maternal pheochromocytoma, and underdevelopment.

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