Malignant mesothelioma and duration of asbestos exposure: Correlation with tissue mineral fibre content

1995 ◽  
Vol 39 (3) ◽  
pp. 363-374 ◽  
Author(s):  
V ROGGLI
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Fibre Content ◽  
Mineral Fibre

Molecular pathogenesis of malignant mesothelioma

2012 ◽  
Vol 14 ◽  
Author(s):  
Philip A. Rascoe ◽  
Daniel Jupiter ◽  
Xiaobo Cao ◽  
James E. Littlejohn ◽  
W. Roy Smythe
Keyword(s):  
Growth Factor ◽  
Malignant Mesothelioma ◽  
Kinase Inhibitors ◽  
Asbestos Exposure ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Chemotherapeutic Agents ◽  
Mineral Fibre ◽  
Multistep Process ◽  
Endothelial Growth Factor

Malignant mesothelioma is a rare, highly aggressive cancer arising from mesothelial cells that line the pleural cavities. Approximately 80% of mesothelioma cases can be directly attributed to asbestos exposure. Additional suspected causes or co-carcinogens include other mineral fibres, simian virus 40 (SV40) and radiation. A mesothelioma epidemic in Turkey has demonstrated a probable genetic predisposition to mineral fibre carcinogenesis and studies of human tissues and animal models of mesothelioma have demonstrated genetic and epigenetic events that contribute to the multistep process of mineral fibre carcinogenesis. Several growth factors and their receptors have a significant role in the oncogenesis, progression and resistance to therapy of mesothelioma. Epidermal growth factor (EGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF) have been shown as targets for therapy based on promising preclinical data. However, clinical trials of tyrosine kinase inhibitors in mesothelioma have been disappointing. Bcl-XL is an important antiapoptotic member of the Bcl-2 family and is overexpressed in several solid tumours, including mesothelioma. Reduction of Bcl-XL expression in mesothelioma induces apoptosis and engenders sensitisation to cytotoxic chemotherapeutic agents. Pharmacological inhibitors of antiapoptotic Bcl-2 family members continue to undergo refinement and have shown promise in mesothelioma.

scholarly journals Mesothelioma in Agriculture in Lombardy, Italy: An Unrecognized Risk

2021 ◽  
Vol 18 (1) ◽  
pp. 358
Author(s):  
Carolina Mensi ◽  
Barbara Dallari ◽  
Marco Polonioli ◽  
Luciano Riboldi ◽  
Dario Consonni ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Agricultural Workers ◽  
Wine Production ◽  
Maintenance And Repair ◽  
Lombardy Region ◽  
Frequent Exposure ◽  
Agricultural Setting ◽  
Jute Bags

Cohort studies showed consistently low risks for malignant mesothelioma (MM) among agricultural workers, however the investigated exposures did not include asbestos. Our aim is to describe sources of asbestos exposure of MM in agriculture. Twenty-six MM cases in agricultural or seed trades workers were identified through the MM registry of the Lombardy region, Italy in 2000–2016. Asbestos exposures were investigated through a standardized questionnaire. The most frequent exposure circumstances were recycled jute bags previously containing asbestos (11 cases) and maintenance and repair of asbestos roofs (12 subjects). Three subjects performed maintenance and repair of tractor asbestos brakes and two used asbestos filters for wine production. Our data suggest asbestos exposure opportunities in the agricultural setting, underlining the need to look for this exposure in subjects affected with mesothelioma.

scholarly journals Yellow Nail Syndrome with Bilateral Pleural Plaques and Diffuse Pleural Thickening: A Mimic of Asbestos Related Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Adam Dallmann ◽  
Richard L. Attanoos
Keyword(s):  
Asbestos Exposure ◽  
Electron Microscopic ◽  
Yellow Nail Syndrome ◽  
Pleural Thickening ◽  
Pleural Plaques ◽  
Pulmonary Manifestations ◽  
Diffuse Pleural Thickening ◽  
Mineral Fibre ◽  
Asbestos Related Disease ◽  
Fibre Analysis

Yellow nail syndrome is a rare acquired condition of unknown aetiology associated with distinct nail discolouration/xanthonychia, pulmonary manifestations, and lymphoedema. Pleural plaques and diffuse pleural thickening are typically, although not exclusively, recognised as markers of prior commercial asbestos exposure. The presence of such biomarkers may assist an asbestos personal injury evaluation. A postmortem examination performed on a 72-year-old man with known long-standing yellow nail syndrome identified pleural plaques and diffuse pleural thickening. An evaluation of the occupational history identified no known asbestos exposure. Electron microscopic mineral fibre analysis detected no asbestos fibres. To the best of our knowledge, this is the only case of yellow nail syndrome in which these benign pleural changes are reported ex asbestos. Alternate causes for such pleural pathology were absent. There is merit in physicians and pathologists having an awareness of these new manifestations when considering claimed asbestos related changes during life and at postmortem.

scholarly journals Scalp Metastasis of Mesothelioma

2021 ◽  
Author(s):  
İlkin Yetişkin ◽  
Berna Eren Kömürcüoğlu ◽  
Eylem Yıldırım
Keyword(s):  
Adrenal Gland ◽  
Malignant Mesothelioma ◽  
Malignant Tumor ◽  
Late Stage ◽  
Poor Prognosis ◽  
Early Stage ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Rare Neoplasm ◽  
Scalp Metastasis

Mesothelioma is a primary malignant tumor of the mesothelial cells lining the pleura, pericardium and peritoneum, which is frequently seen between the ages of 40-60. Malignant mesothelioma (MM) is a rare neoplasm with a poor prognosis, usually associated with asbestos exposure. It is characterized by aggressive local invasion and metastatic spread. Extrathoracic lymphogenous-hematogenous metastases are rare at the time of diagnosis and in the early stage. However, metastases develop in at least half of the cases in the late stage of the disease. After the spread of serous membranes, distant metastases to the bone, adrenal gland, and liver are frequently observed. Skin and scalp metastases are rarely observed. Our case MPM is presented because it is a rare scalp metastasis.

scholarly journals A CLINICAL STUDY OF MALIGNANT MESOTHELIOMA

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Ankit Agarwal ◽  
Abhishek Padhiar ◽  
Arun Pandey ◽  
Giriraj Prajapati
Keyword(s):  
Weight Loss ◽  
Chest Pain ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Symptom Duration ◽  
Karnofsky Performance Score ◽  
Survival Times ◽  
Aggressive Tumor ◽  
Histopathological Type ◽  
Diagnosis Date

Background: Malignant Mesothelioma (MM) is a rare but rapidly fatal and aggressive tumor of the pleura and peritoneum with limited knowledge of its natural history. Methods: 100 patients with histopathological MM diagnosis were included. The data obtained from patient files were recorded on standard forms, prepared in advance. Age, gender, hometown, residence, asbestos usage history, latent period between asbestos exposure and diagnosis, symptoms, symptom duration, diagnosis date, diagnostic method, localization, histopathological type, routine laboratory results, stage, karnofsky performance score (KPS), treatment regimen, pleurodesis, treatment response, date of death and survival times of patients were all recorded on the forms. Results: The mean age of patients 52.31±12.36 Yrs. 62 patients were male and 38 female. Environmental asbestos exposure was determined in 75.00% of patients At diagnosis, 76.00% patients had dyspnea; 71.00% weight loss; and 64.00% chest pain. A total of 48.00% patients were smokers. Mean survival time was found to be 9.3 months in our study. Conclusion: MM related to asbestos exposure is seen frequently in Southern Rajastan. Patients present with the typical clinical features of dyspnea, weight loss, and chest pain. Keywords: MM, Absestos, Dyspnea.

scholarly journals Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China

JAMA Oncology ◽  
2017 ◽  
Vol 3 (4) ◽  
pp. 562 ◽  
Author(s):  
Weimin Mao ◽  
Xing Zhang ◽  
Zhenying Guo ◽  
Zhibin Gao ◽  
Harvey I. Pass ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Eastern China

scholarly journals Validation of an Asbestos Job-Exposure Matrix (AsbJEM) in Australia: Exposure–Response Relationships for Malignant Mesothelioma

2019 ◽  
Vol 63 (7) ◽  
pp. 719-728 ◽  
Author(s):  
Hiroyuki Kamiya ◽  
Susan Peters ◽  
Nita Sodhi-Berry ◽  
Alison Reid ◽  
Len Gordon ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Proportional Hazards ◽  
Asbestos Exposure ◽  
Occupational Exposures ◽  
Peak Frequency ◽  
Cox Proportional Hazards ◽  
Surveillance Program ◽  
Average Intensity ◽  
Job Exposure Matrix ◽  
Exposure Response

Abstract Objectives An asbestos job-exposure matrix (AsbJEM) has been developed to systematically and cost-effectively evaluate occupational exposures in population-based studies. The primary aim of this study was to examine the accuracy of the AsbJEM in determining exposure–response relationships between asbestos exposure estimates and malignant mesothelioma (MM) incidence (indirect validation). The secondary aim was to investigate whether the assumptions used in the development of the original AsbJEM provided accurate asbestos exposure estimates. Methods The study population consisted of participants in an annual health surveillance program, who had at least 3-month occupational asbestos exposure. Calculated asbestos exposure indices included cumulative asbestos exposure and the average exposure intensity, estimated using the AsbJEM and duration of employment. Asbestos and MM exposure–response relationships were compared between the original AsbJEM and its variations based on manipulations of the intensity, duration and frequency of exposure. Twenty-four exposure estimates were calculated for both cumulative asbestos exposure and the average exposure intensity using three exposure intensities (50th, 75th and 90th percentile of the range of mode exposure), four peak durations (15, 30, 60 and 120 min) and two patterns of peak frequency (original and doubled). Cox proportional hazards models were used to describe the associations between MM incidence and each of the cumulative and average intensity estimates. Results Data were collected from 1602 male participants. Of these, 40 developed MM during the study period. There were significant associations between MM incidence and both cumulative and average exposure intensity for all estimates. The strongest association, based on the regression-coefficient from the models, was found for the 50th percentile of mode exposure, 15-min peak duration and the doubled frequency of peak exposure. Using these assumptions, the hazard ratios for mesothelioma were 1 (reference), 1.91, 3.24 and 5.37 for the quartiles of cumulative asbestos exposure and 1 (reference), 1.84, 2.31 and 4.40 for the quartiles of the average exposure intensity, respectively. Conclusion The well-known positive exposure–response relationship between MM incidence and both estimated cumulative asbestos exposure and average exposure intensity was confirmed. The strongest relationship was found when the frequency of peak exposure in the AsbJEM was doubled from the originally published estimates.

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