Urinary excretion of coenzyme Q10 by patients with diabetes mellitus

1961 ◽  
Vol 95 (2) ◽  
pp. 348-351 ◽  
Author(s):  
Stanley S. Bergen ◽  
Frank R. Koniuszy ◽  
A.C. Page ◽  
Karl Folkers
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Excretion ◽  
Coenzyme Q10 ◽  
Patients With Diabetes

scholarly journals Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus

2016 ◽  
Vol 9 ◽  
pp. NMI.S40595 ◽  
Author(s):  
Hiromi Iwakawa ◽  
Yasuyuki Nakamura ◽  
Tomiho Fukui ◽  
Tsutomu Fukuwatari ◽  
Satoshi Ugi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Excretion ◽  
Water Soluble ◽  
Confounding Factors ◽  
Linear Regression Models ◽  
Food Record ◽  
Patients With Diabetes ◽  
Weighed Food Record ◽  
Healthy Control ◽  
Renal Clearances

We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.

Urinary excretion of markers for podocyte injury in patients with diabetes mellitus

2015 ◽  
Vol 87 (10) ◽  
pp. 62 ◽  
Author(s):  
A. A. Shchukina ◽  
I. N. Bobkova ◽  
M. V. Shestakova ◽  
O. K. Vikulova ◽  
Z. T. Zuraeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Excretion ◽  
Podocyte Injury ◽  
Patients With Diabetes

scholarly journals Urinary excretion of kappa light chains in patients with diabetes mellitus

1990 ◽  
Vol 37 (4) ◽  
pp. 1120-1125 ◽  
Author(s):  
Leif Groop ◽  
Anne Mäkipernaa ◽  
Svante Stenman ◽  
Ralph A. DeFronzo ◽  
Anna-Maija Teppo
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Excretion ◽  
Light Chains ◽  
Patients With Diabetes ◽  
Kappa Light Chains

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Desmopressin Stimulates Parallel Norepinephrine and Tissue Plasminogen Activator Release in Normal Subjects and Patients with Diabetes Mellitus

1988 ◽  
Vol 59 (02) ◽  
pp. 269-272 ◽  
Author(s):  
M B Grant ◽  
C Guay ◽  
R Lottenberg
Keyword(s):  
Diabetes Mellitus ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Time Course ◽  
Vascular Endothelial Cells ◽  
Normal Subjects ◽  
Plasma Norepinephrine ◽  
Endogenous Catecholamine ◽  
Tissue Plasminogen ◽  
Patients With Diabetes

SummaryDesmopressin acetate administration markedly stimulates release of tissue plasminogen activator (t-PA) from vascular endothelial cells. The mechanism for this effect is unknown. Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA release by desmopressin. Intravenous desmopressin acetate (0.3 μg/kg) was infused over 30 min in 9 controls and 11 subjects with diabetes mellitus, a condition associated with abnormalities of the fibrinolytic system. Plasma was collected in the supine, overnight fasted state at 15 min intervals (0-60 min) for measurement of t-PA activity, t-PA antigen and fractionated catecholamines. t-PA activity peaked at 30-45 min and subsequently decreased. The norepinephrine levels paralleled the t-PA activity. t-PA activity increased 10-fold from 0.14 ± .12 to 1.49 ± 0.79 IU/ml (Mean ± SD) and plasma norepinephrine increased 2- fold from 426 ± 90 to 780 ± 292 pg/ml. However, epinephrine and dopamine levels did not change significantly. The response to desmopressin of control and diabetic subjects was not shown to differ and their data were combined. We conclude that desmopressin increases plasma norepinephrine in addition to t-PA and that the parallel time course of change suggests a possible role for norepinephrine in mediating endothelial cell t-PA release.

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