Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus

We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.

Download Full-text

Diabetes-induced Alterations in HDL Subfractions Distribution

Current Pharmaceutical Design ◽

10.2174/1381612825666190227224246 ◽

2020 ◽

Vol 26 (27) ◽

pp. 3341-3348 ◽

Cited By ~ 1

Author(s):

Marek Femlak ◽

Anna Gluba-Brzozka ◽

Beata Franczyk ◽

Jacek Rysz

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Risk ◽

Public Health Problem ◽

Statin Treatment ◽

Oxidative Modification ◽

Control Group ◽

Newly Diagnosed ◽

Hdl Subfractions ◽

Patients With Diabetes ◽

Healthy Control

Introduction: Diabetes mellitus (DM) due to its increasing prevalence and associated morbidity and mortality has become a serious public health problem. In DM, HDL may lose its beneficial features and become proatherogenic due to its altered biological activity thus increasing cardiovascular risk. The aim of this study was to assess the influence of the presence of diabetes mellitus type 2 and its duration on the distribution of HDL subfractions. Moreover, the effect of statin treatment on HDL subfraction share was analysed in this study. Methods: The study group consisted of 50 patients with newly diagnosed DM and 50 persons with DM for longer than 10 years while the control group consisted of 50 healthy volunteers. HDL subfractions were analysed with the use of Lipoprint. Results: We demonstrated progressive worsening of heart functioning and impairment of its structure in the course of diabetes mellitus. Moreover, we observed that HDL-6 subfraction and intermediate HDL fraction are lowest in the group with advanced DMt2 compared to the group with newly diagnosed DM and a healthy control group. Finally, the results of our study indicated the effect of statin treatment on HDL subfractions that seems not to be advantageous. Conclusion: It seems that in patients with diabetes mellitus compromised antiatherogenic properties of HDL, as a result of oxidative modification and glycation of the HDL protein as well as the transformation of the HDL proteome into a proinflammatory protein, increase cardiovascular risk.

Download Full-text

Urinary excretion of markers for podocyte injury in patients with diabetes mellitus

Terapevticheskii arkhiv ◽

10.17116/terarkh2015871062-66 ◽

2015 ◽

Vol 87 (10) ◽

pp. 62 ◽

Cited By ~ 2

Author(s):

A. A. Shchukina ◽

I. N. Bobkova ◽

M. V. Shestakova ◽

O. K. Vikulova ◽

Z. T. Zuraeva ◽

...

Keyword(s):

Diabetes Mellitus ◽

Urinary Excretion ◽

Podocyte Injury ◽

Patients With Diabetes

Download Full-text

Renal Isoamylase Clearance as a Measure of Altered Renal Charge Selectivity in Patients with Diabetes Mellitus

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456329303000506 ◽

1993 ◽

Vol 30 (5) ◽

pp. 449-453 ◽

Cited By ~ 1

Author(s):

C N Thum ◽

R S Oelbaum ◽

A Y Foo ◽

S B Rosalki

Keyword(s):

Diabetes Mellitus ◽

Renal Damage ◽

Diabetic Patients ◽

Healthy Controls ◽

Salivary Amylase ◽

Early Marker ◽

Charge Selectivity ◽

Patients With Diabetes ◽

Renal Clearances

Microalbuminuria is well established as a marker for early renal damage in diabetic patients. Differences in charge selectivity in glomerular protein filtration may also be an early marker of renal damage. We investigated the possible usefulness of the renal clearances of pancreatic and salivary amylases, and the ratio of the two, as markers of early renal damage in 55 diabetic subjects and 21 healthy controls. Diabetic patients with established albuminuria and microalbuminuria had increased clearance of salivary amylase and a trend toward lower pancreatic/salivary amylase clearance ratios compared to healthy controls and diabetic subjects without albuminuria, but the overlap with controls and diabetics without albuminuria was too large for the test to be useful.

Download Full-text

Urinary excretion of coenzyme Q10 by patients with diabetes mellitus

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(61)90158-8 ◽

1961 ◽

Vol 95 (2) ◽

pp. 348-351 ◽

Cited By ~ 3

Author(s):

Stanley S. Bergen ◽

Frank R. Koniuszy ◽

A.C. Page ◽

Karl Folkers

Keyword(s):

Diabetes Mellitus ◽

Urinary Excretion ◽

Coenzyme Q10 ◽

Patients With Diabetes

Download Full-text

Down-regulation of PM20D1 is associated with clinics outcomes and prognosis of gestational patients with diabetes mellitus

Archives of Medical Science ◽

10.5114/aoms/136284 ◽

2021 ◽

Author(s):

Lieming Zhang

Keyword(s):

Diabetes Mellitus ◽

Gestational Age ◽

Pregnancy Outcomes ◽

Serum Levels ◽

Inflammatory Factors ◽

Second Trimester ◽

Third Trimester ◽

Tnf Α ◽

Patients With Diabetes ◽

Healthy Control

IntroductionTo investigate clinic role of PM20D1 in gestational diabetes mellitus (GDM).Material and methodsThis observational study included 189 cases of GDM patients who came to our department during March 2018 to December 2019. Additionally, 100 healthy pregnant individuals who came to physical examination were included as healthy control during the same period. Western blotting was used to determine the expression of PM20D1 at gestational age 24-28 weeks, as well as gestational age 37-40 weeks. Serum inflammatory factors of C reactive protein (CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α.ResultsThe expression of PM20D1 was markedly decreased in GDM patients compared with the healthy control. Besides, patients of third trimester of pregnancy (gestational age 37-40 weeks) showed significantlylower expression of PM20D1 than patients of second trimester of pregnancy (gestational age 24-28 weeks). Serum levels of CRP, IL-1β, IL-6, TNF-α and leptin were remarkably higher and levels of adiponectin were markedly lower in GDM patients at both second and third trimester of pregnancy, which were the highest at third trimester of pregnancy. Pearson’s analysis showed PM20D1 was negatively correlated with IL-1β, IL-6 and leptin and positively correlated with adiponectin. At second trimester of pregnancy, patients with lower expression of PM20D1 showed remarkably higher levels of HOMA-IR, fasting insulin, FBG, OGTT-1hPG, OGTT-2hPG, as well as TG and LDL-ch, as well as markedly lower levels of HDL-ch. Down-regulated PM20D1 predicted poor pregnancy outcomes.ConclusionsReduced was PM20D1 associated with patients’ clinics outcomes and pregnancy outcomes in GDM.

Download Full-text

Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells in Healthy Control Subjects and Patients with Diabetes mellitus, Acute Coronary Syndrome, Stroke, and Arterial Hypertension

Scandinavian Journal of Infectious Diseases ◽

10.1080/00365540310016538 ◽

2003 ◽

Vol 35 (10) ◽

pp. 704-712 ◽

Cited By ~ 18

Author(s):

Jakob Müller ◽

Dorthe S. Møller ◽

Mogens Kjær ◽

Ole Nyvad ◽

Niels A. Larsen ◽

...

Keyword(s):

Diabetes Mellitus ◽

Acute Coronary Syndrome ◽

Arterial Hypertension ◽

Chlamydia Pneumoniae ◽

Mononuclear Cells ◽

Peripheral Blood Mononuclear ◽

Coronary Syndrome ◽

Blood Mononuclear Cells ◽

Patients With Diabetes ◽

Healthy Control

Download Full-text

Evaluation of plasma VEGF and sVEGFR-1 levels in patients with diabetes mellitus receiving insulin treatment

Turkish Journal of Biochemistry ◽

10.1515/tjb-2017-0348 ◽

2019 ◽

Vol 44 (2) ◽

pp. 182-188

Author(s):

Ismail Erturk ◽

Erdim Sertoglu ◽

Fatih Yesildal ◽

Ramazan Acar ◽

Kenan Saglam ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Treatment ◽

Assay Method ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Vegf Receptor ◽

Vascular Endothelial ◽

Patients With Diabetes ◽

Healthy Control ◽

Endothelial Growth Factor

Abstract Background Diabetes mellitus (DM) is a multifactorial chronic disease, in which patients need to be treated with insulin in some conditions. Capillary growth is regulated by growth factors like vascular endothelial growth factor (VEGF) and endogenous inhibitors such as the splice variant of VEGF receptor-1 (sVEGFR-1). We aimed to show the levels and the clinical significance of VEGF, sVEGFR-1 in patients with DM on insulin treatment. Materials and methods A total of 83 subjects consisting of patients with the diagnosis of DM (n=47) and healthy control (n=36) were included the study. Plasma levels of VEGF and sVEGFR-1, were measured using the enzyme-linked immunosorbent assay method. Results The average sVEGFR-1 levels of DM group was significantly higher than the control group (0.106±0.052 and 0.073±0.049, respectively; p=0.005). Significantly lower sVEGFR-1 levels were determined in patients receiving metformin vs. without metformin using (0.065±0.016 and 0.118±0.053, respectively; p=0.001). Conclusion This is the first study evaluating and demonstrating the importance of plasma VEGF and sVEGFR-1 levels together in DM patients receiving insulin. Using metformin may have positive effect on angiogenesis in DM. Further studies are required to understand these effects.

Download Full-text

Urinary excretion patterns of endogenously produced alcohols in type 1 (IDDM) and type 2 (NIDDM) diabetes mellitus compared with healthy control subjects

Diabetes Research and Clinical Practice ◽

10.1016/0168-8227(90)90039-v ◽

1990 ◽

Vol 10 (2) ◽

pp. 161-165 ◽

Cited By ~ 8

Author(s):

Kornelia Krönert ◽

M. Künzel ◽

B. Reutter ◽

C. Zimmermann ◽

H.M. Liebich ◽

...

Keyword(s):

Diabetes Mellitus ◽

Urinary Excretion ◽

Control Subjects ◽

Healthy Control

Download Full-text

Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese schoolchildren

Public Health Nutrition ◽

10.1017/s1368980010001904 ◽

2010 ◽

Vol 14 (2) ◽

pp. 327-333 ◽

Cited By ~ 16

Author(s):

Tomiko Tsuji ◽

Tsutomu Fukuwatari ◽

Satoshi Sasaki ◽

Katsumi Shibata

Keyword(s):

Elementary School ◽

Pantothenic Acid ◽

Water Soluble ◽

Vitamin B ◽

Food Record ◽

Free Living ◽

Water Soluble Vitamin ◽

Potential Biomarker ◽

Urinary Levels ◽

Weighed Food Record

AbstractObjectiveTo examine the association between 24 h urinary water-soluble vitamin levels and their intakes in free-living Japanese schoolchildren.DesignAll foods consumed for four consecutive days were recorded accurately by a weighed food record. A single 24 h urine sample was collected on the fourth day, and the urinary levels of water-soluble vitamins were measured.SettingAn elementary school in Inazawa City, Japan.SubjectsA total of 114 healthy, free-living, Japanese elementary-school children aged 10–12 years.ResultsThe urinary level of each water-soluble vitamin was correlated positively to its mean intake in the past 2–4 d (vitamin B1: r = 0·42, P < 0·001; vitamin B2: r = 0·43, P < 0·001; vitamin B6: r = 0·49, P < 0·001; niacin: r = 0·32, P < 0·001; niacin equivalents: r = 0·32, P < 0·001; pantothenic acid: r = 0·32, P < 0·001; folic acid: r = 0·27, P < 0·01; vitamin C: r = 0·39, P < 0.001), except for vitamin B12 (r = 0·10, P = NS). Estimated mean intakes of water-soluble vitamins calculated using urinary levels and recovery rates were 97–102 % of their 3 d mean intake, except for vitamin B12 (79 %).ConclusionsThe results show that urinary levels of water-soluble vitamins, except for vitamin B12, reflected their recent intakes in free-living Japanese schoolchildren and could be used as a potential biomarker to estimate mean vitamin intake.

Download Full-text