Natural antibodies in man to a protein antigen from the bacterium Streptococcus mutans related to dental caries experience

1984 ◽  
Vol 29 (3) ◽  
pp. 179-184 ◽  
Author(s):  
S.J. Challacombe ◽  
Lesley A. Bergmeier ◽  
Anita S. Rees
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Natural Antibodies ◽  
Protein Antigen ◽  
Caries Experience

scholarly journals Correlation between the salivary Streptococcus mutans levels and dental caries experience in adult population of Chandigarh, India

2013 ◽  
Vol 07 (02) ◽  
pp. 191-195 ◽  
Author(s):  
Parampreet Pannu ◽  
Ramandeep Gambhir ◽  
Amrita Sujlana
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Adult Population ◽  
Positive Association ◽  
Caries Experience ◽  
Bacterial Titer ◽  
Males And Females ◽  
The Mean ◽  
Sample Score ◽  
Commercial Kits

ABSTRACT Objective: To determine the level of Streptococcus mutans (S. mutans) in adults of Chandigarh and to correlate the dental caries in these individuals with their S. mutans titers. Materials and Methods: Salivary levels of Streptococcus mutans, using Dentocult SM commercial kits were estimated in 200, 25-35 year old adults (males and females). Streptococcus mutans were detected in 87% of the study sample. Score 2, representing 105 - 106 CFU/ml (Colony Forming Unit) of saliva was found to be most prevalent, i.e. in 80 of 200 adults, followed by score 1, depicting S mutans with <105 CFU/ml, in 56 of 200 adults and score 3, with bacterial titer <106 CFU/ml in 38 of 200 adults. Results: Dental caries, recorded using Møller′s index, was found to be maximum in individuals with score 3, followed by score 2,1 and 0, thereby showing a positive correlation of dental caries with increasing titers of S. mutans. This correlation was statistically highly significant in males with figures as 8.73 decayed surfaces at score 2 rising to 17.38 at score 3. The mean of DMFT was higher among females than in the males in the present study. Conclusion: The split up data in males and females, showed a positive association between caries experience and salivary S. mutans scores. The results of the study will serve as a baseline data for future planning of preventive programs in adults.

A DNA Vaccine Encoding a Cell-surface Protein Antigen of Streptococcus mutans Protects Gnotobiotic Rats from Caries

2002 ◽  
Vol 81 (11) ◽  
pp. 784-787 ◽  
Author(s):  
M.W. Fan ◽  
Z. Bian ◽  
Z.X. Peng ◽  
Y. Zhong ◽  
Z. Chen ◽  
...  
Keyword(s):  
Dental Caries ◽  
Cell Surface ◽  
Streptococcus Mutans ◽  
Dna Vaccine ◽  
Recombinant Dna ◽  
Surface Protein ◽  
Protein Antigen ◽  
Cell Surface Protein ◽  
Igg Antibody ◽  
A Cell

A cell-surface protein antigen (PAc) of Streptococcus mutans is considered a virulence factor because it may mediate initial attachment of Streptococcus mutans to tooth surfaces. Thus, inhibiting PAc is predicted to provide protection against caries. To develop vaccines against dental caries, we constructed a DNA vaccine, pCIA-P, which encodes two high-conservative regions of PAc. Expression of the recombinant protein was obtained in eukaryotic cells in vitro and in vivo. In this report, we provide evidence that fewer caries lesions, and high levels of PAc-specific salivary IgA antibody and serum IgG antibody, were observed in gnotobiotic rats following targeted salivary gland (TSG) administration of pCIA-P. This study shows that the recombinant DNA vaccine pCIA-P could induce protective anti-caries immune responses and that TSG immunization is a promising strategy for the inhibition of dental caries.

scholarly journals Interdental Localization of Streptococcus mutans as Related to Dental Caries Experience

1974 ◽  
Vol 9 (3) ◽  
pp. 481-488 ◽  
Author(s):  
R. J. Gibbons ◽  
P. F. Depaola ◽  
D. M. Spinell ◽  
Z. Skobe
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Caries Experience

scholarly journals Genotypic diversity of Streptococcus mutans isolated from preschoolers with and without early dental care

2019 ◽  
Vol 48 ◽  
Author(s):  
Ana Lídia Soares COTA ◽  
Janaína Accordi JUNKES ◽  
Regina Célia POLI-FREDERICO
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Dental Care ◽  
Random Amplified Polymorphic Dna ◽  
Genotypic Diversity ◽  
Caries Experience ◽  
Oral Microbiota ◽  
Preventive Program ◽  
Arbitrary Primers ◽  
History Of

Abstract Introduction Streptococcus mutans (S. mutans) exhibits extensive genotypic diversity, but the role of this variation is poorly understood. Objective To evaluate the genotypic diversity of S. mutans in preschoolers with and without early dental care and to associate it with dental caries experience. Material and method Twenty children, aged five year old, with history of dental care since they were one year old (G1) and 20 children without history of dental care (G2) were included. Their oral health status was assessed by the dmft index. S. mutans samples were isolated from the saliva and analysed by polymerase chain reaction. A total of 339 S. mutans isolates (173 from G1 and 166 from G2) were genotyped by random amplified polymorphic DNA with arbitrary primers OPA-02 and OPA-13. Result The results revealed 75 distinct genotypes of S. mutans in G1 and 73 in G2. Furthermore, G1 and G2 subjects harboured one to eight and one to seven distinct genotypes of S. mutans, respectively. A statistically significant association (P=0.021) and a moderate correlation (r= 0.503) were observed between dental caries experience and genotypic diversity of S. mutans in G1. Conclusion From the limitations of the study design, we just can hypothesize that actions of early dental care carried out by an educative-preventive program can contribute to a distinct oral microbiota.

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