Expression of nuclear retinoic acid receptors in rat adipose tissue

1991 ◽  
Vol 176 (3) ◽  
pp. 1539-1544 ◽  
Author(s):  
Riaz-ul-Haq ◽  
Frank Chytil
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Retinoic Acid Receptors ◽  
Rat Adipose Tissue

scholarly journals Retinoic acid receptor γ 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes

1993 ◽  
Vol 293 (3) ◽  
pp. 807-812 ◽  
Author(s):  
Y Kamei ◽  
T Kawada ◽  
R Kazuki ◽  
E Sugimoto
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Mrna Expression ◽  
De Novo ◽  
Retinoic Acid Receptor ◽  
Mrna Level ◽  
Fold Increase ◽  
Dependent Manner ◽  
Alpha Beta ◽  
Rat Adipose Tissue

Retinoids, especially all-trans retinoic acid (RA), have been shown to inhibit the differentiation of preadipose cells. In the present study, the expression of retinoic acid receptors (RAR alpha, beta and gamma) and retinoid X receptors (RXR alpha, beta and gamma) was examined by Northern blot analysis in rat adipose tissue and mouse 3T3-L1 adipose cells. The adipose tissue and/or 3T3-L1 cells expressed mRNAs for a number of nuclear retinoid receptors, including RAR alpha, beta and gamma, and RXR alpha, beta and gamma. RAR alpha, RAR gamma, RXR alpha and RXR beta mRNAs were abundant in adipose tissue and 3T3-L1 cells. RXR gamma mRNA was detected in adipose tissue but not in 3T3-L1 cells. Treatment of 3T3-L1 cells with 1 microM RA led to a 4-5-fold increase in the RAR gamma mRNA level, but only a trace amount of RAR beta mRNA was detected. RAR gamma mRNA expression was rapidly (within 2 h) induced by physiological concentrations of RA in a dose-dependent manner. The response of RAR gamma mRNA expression to RA was reversible; rapid disappearance of RAR gamma mRNA occurred on RA removal. In addition, the induction of RAR gamma expression did not require de novo protein synthesis, but was completely abolished by an inhibitor of RNA synthesis. Using RAR gamma 1 and gamma 2 isoform-specific probes, the patterns of RAR gamma 1 and gamma 2 mRNA expression in 3T3-L1 cells in the presence and absence of RA were examined. RAR gamma 1 mRNA was detected in 3T3-L1 cells but was not affected by RA treatment; however, RAR gamma 2 mRNA was strongly induced by RA.

scholarly journals Apo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors

2011 ◽  
Vol 1811 (12) ◽  
pp. 1105-1114 ◽  
Author(s):  
E. Gouranton ◽  
G. Aydemir ◽  
E. Reynaud ◽  
J. Marcotorchino ◽  
C. Malezet ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Retinoic Acid Receptors ◽  
Tissue Biology

scholarly journals Effects of age and cell size on rat adipose tissue metabolism.

1975 ◽  
Vol 16 (6) ◽  
pp. 461-464 ◽  
Author(s):  
G Holm ◽  
B Jacobsson ◽  
P Björntorp ◽  
U Smith
Keyword(s):  
Adipose Tissue ◽  
Cell Size ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Rat Adipose Tissue
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