Influence of long-chain free fatty acids on the binding of warfarin to bovine serum albumin

1976 ◽  
Vol 25 (22) ◽  
pp. 2515-2521 ◽  
Author(s):  
Saroj K. Chakrabarti ◽  
Réal Laliberté ◽  
Jules Brodeur
1969 ◽  
Vol 10 (1) ◽  
pp. 56-67
Author(s):  
Arthur A. Spector ◽  
Kathryn John ◽  
John E. Fletcher

1970 ◽  
Vol 44 (2) ◽  
pp. 354-360 ◽  
Author(s):  
Joseph B. Warshaw ◽  
Mary L. Terry

In view of the importance of fatty acids as substrates for the mature heart, fatty acid oxidation by fetal and calf heart mitochondria has been investigated. Free fatty acids of 10 carbon units or less which exhibit carnitine-independent transport into mitochondria were effective substrates for oxidative phosphorylation in both fetal and calf heart mitochondria. Efficient oxidative phosphorylation with these substrates was dependent upon the presence of bovine serum albumin in the assay medium to reverse the uncoupling effects of the fatty acids. In the presence of bovine serum albumin, ADP/0 ratios were in the range of 3 when short-chain fatty acids and carnitine esters of short- and long-chain fatty acids were substrates. Compared with calf heart mitochondria, fetal heart mitochondria showed decreased carnitine-dependent oxidation of palmityl-CoA. However, the oxidation of palmitylcarnitine was identical in both. These data suggest that the formation of palmitylcarnitine is rate limiting for palmityl-CoA oxidation by the fetal heart mitochondria and that long-chain fatty acids are not readily oxidized by the fetal heart.


Lipids ◽  
1990 ◽  
Vol 25 (10) ◽  
pp. 633-638 ◽  
Author(s):  
Sadao Watanabe ◽  
Takayuki Tani ◽  
Shigenobu Watanabe ◽  
Manabu Senō

2008 ◽  
Vol 63 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Dzmitry Shcharbin ◽  
M. Francesca Ottaviani ◽  
Michela Cangiotti ◽  
Magdalena Przybyszewska ◽  
Marian Zaborski ◽  
...  

Biochemistry ◽  
1982 ◽  
Vol 21 (17) ◽  
pp. 4059-4064 ◽  
Author(s):  
Ray C. Perkins ◽  
Nada Abumrad ◽  
K. Balasubramanian ◽  
L. R. Dalton ◽  
Albert H. Beth ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document