5-Hydroxytryptamine in the central nervous system and sexual receptivity of female rhesus monkeys

1975 ◽  
Vol 88 (2) ◽  
pp. 281-293 ◽  
Author(s):  
P.B. Gradwell ◽  
B.J. Everitt ◽  
J. Herbert
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Sexual Receptivity ◽  
Female Rhesus ◽  
The Central Nervous System

SARS-CoV-2 Invades the Central Nervous System via the Olfactory Route in Rhesus Monkeys

2020 ◽  
Author(s):  
Li Jiao ◽  
Yun Yang ◽  
Wenhai Yu ◽  
Yuan Zhao ◽  
Haiting Long ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
The Central Nervous System

THE EFFECTS OF DEXAMETHASONE AND ANDROGENS ON SEXUAL RECEPTIVITY OF FEMALE RHESUS MONKEYS

1971 ◽  
Vol 51 (3) ◽  
pp. 575-588 ◽  
Author(s):  
B. J. EVERITT ◽  
J. HERBERT
Keyword(s):  
Rhesus Monkeys ◽  
Testosterone Propionate ◽  
Secretory Activity ◽  
Urinary Free Cortisol ◽  
Sexual Receptivity ◽  
Adrenal Androgens ◽  
Electrolyte Metabolism ◽  
Free Cortisol ◽  
Female Rhesus ◽  
The Central Nervous System

SUMMARY The effect of dexamethasone, given either alone or together with testosterone propionate or androstenedione, was studied in nine female rhesus monkeys (paired with three males) by making quantitative observations on behaviour in the laboratory. Dexamethasone (0·5 mg/kg/day) given to oestrogen-treated ovariectomized female monkeys made them sexually unreceptive, and there was an associated decline in the level of the male's mounting activity. Testosterone propionate (100 or 200 μg/day) reversed completely the effects of dexamethasone on sexual behaviour. Androstenedione (100, 200 or 400 μg/day) had similar, but less marked, effects whereas cortisol (10 mg/day) or progesterone (100, 200 or 500 μg/day) were ineffective. Treating a female with testosterone prevented dexamethasone from reducing sexual receptivity. Parallel determinations of urinary free cortisol showed that the dexamethasone had suppressed the secretory activity of the adrenal cortex. There were no consistent changes, under any treatment, in the females' vaginal epithelia, sexual skins or clitorides, or in their water or electrolyte metabolism. These findings indicate that adrenal androgens regulate sexual receptivity in these female primates, probably by an action on the central nervous system.

Lack of effect of morphine, reserpine, and halothane on oscillation of plasma insulin in M. mulatta

1981 ◽  
Vol 240 (1) ◽  
pp. E1-E4 ◽  
Author(s):  
F. G. Hom ◽  
D. J. Koerker ◽  
C. J. Goodner
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Plasma Insulin ◽  
Insulin Levels ◽  
Plasma Insulin Levels ◽  
The Central Nervous System ◽  
Male Rhesus

Oscillating plasma insulin levels, with periods averaging 9 min, in fasting rhesus monkeys have been previously reported by us. To test whether an oscillator in the central nervous system might be driving these oscillations, we subjected five male rhesus monkeys to morphine, reserpine, and halothane, agents known to affect the central nervous system, in an attempt to either disrupt or change the frequency of the oscillations. We could demonstrate no significant effect of any of the three drugs on the oscillations. We conclude, therefore, that the oscillations in plasma insulin are not driven by an oscillator in the central nervous system. Coupled with the results of others, these data suggest that these oscillations are probably due to an intrinsic pancreatic pacemaker.

scholarly journals Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys

Cell ◽  
2017 ◽  
Vol 169 (4) ◽  
pp. 610-620.e14 ◽  
Author(s):  
Malika Aid ◽  
Peter Abbink ◽  
Rafael A. Larocca ◽  
Michael Boyd ◽  
Ramya Nityanandam ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lymph Nodes ◽  
Zika Virus ◽  
Rhesus Monkeys ◽  
Virus Persistence ◽  
The Central Nervous System

scholarly journals The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Li Jiao ◽  
Yun Yang ◽  
Wenhai Yu ◽  
Yuan Zhao ◽  
Haiting Long ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Primate Model ◽  
The Central Nervous System ◽  
Functional Areas ◽  
Human Primate

AbstractNeurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.

scholarly journals THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

1947 ◽  
Vol 85 (1) ◽  
pp. 117-130 ◽  
Author(s):  
Elvin A. Kabat ◽  
Abner Wolf ◽  
Ada E. Bezer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Demyelinating Disease ◽  
Acute Disseminated Encephalomyelitis ◽  
Rabbit Brain ◽  
Adult Rabbit ◽  
Rabbit Lung ◽  
The Central Nervous System ◽  
Experimental Findings

1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and histological findings in the central nervous system is given and compared with features of human demyelinating disease. 4. The experimental findings are in accord with the hypothesis that antibody to the injected brain emulsion reacts with the tissues of the nervous system of the animal to produce the pathological changes.

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