Lack of effect of morphine, reserpine, and halothane on oscillation of plasma insulin in M. mulatta

1981 ◽  
Vol 240 (1) ◽  
pp. E1-E4 ◽  
Author(s):  
F. G. Hom ◽  
D. J. Koerker ◽  
C. J. Goodner

Oscillating plasma insulin levels, with periods averaging 9 min, in fasting rhesus monkeys have been previously reported by us. To test whether an oscillator in the central nervous system might be driving these oscillations, we subjected five male rhesus monkeys to morphine, reserpine, and halothane, agents known to affect the central nervous system, in an attempt to either disrupt or change the frequency of the oscillations. We could demonstrate no significant effect of any of the three drugs on the oscillations. We conclude, therefore, that the oscillations in plasma insulin are not driven by an oscillator in the central nervous system. Coupled with the results of others, these data suggest that these oscillations are probably due to an intrinsic pancreatic pacemaker.

2020 ◽  
Author(s):  
Li Jiao ◽  
Yun Yang ◽  
Wenhai Yu ◽  
Yuan Zhao ◽  
Haiting Long ◽  
...  

Cell ◽  
2017 ◽  
Vol 169 (4) ◽  
pp. 610-620.e14 ◽  
Author(s):  
Malika Aid ◽  
Peter Abbink ◽  
Rafael A. Larocca ◽  
Michael Boyd ◽  
Ramya Nityanandam ◽  
...  

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Li Jiao ◽  
Yun Yang ◽  
Wenhai Yu ◽  
Yuan Zhao ◽  
Haiting Long ◽  
...  

AbstractNeurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.


1947 ◽  
Vol 85 (1) ◽  
pp. 117-130 ◽  
Author(s):  
Elvin A. Kabat ◽  
Abner Wolf ◽  
Ada E. Bezer

1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and histological findings in the central nervous system is given and compared with features of human demyelinating disease. 4. The experimental findings are in accord with the hypothesis that antibody to the injected brain emulsion reacts with the tissues of the nervous system of the animal to produce the pathological changes.


1949 ◽  
Vol 89 (6) ◽  
pp. 567-582 ◽  
Author(s):  
Gilbert Dalldorf ◽  
Grace M. Sickles ◽  
Hildegard Plager ◽  
Rebecca Gifford

A virus has been recovered from the feces of two children having symptoms similar to those of poliomyelitis. The virus is pathogenic for suckling mice and hamsters but not for rhesus monkeys. It induces striking lesions in the skeletal muscles of the experimental animal but not in the central nervous system. Other viruses inducing similar signs and lesions in suckling mice have been isolated from several other outbreaks of a poliomyelitis-like disease, including one large urban epidemic.


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