Short-chain glucose polymer and anthracene-9-carboxylic acid inhibit water and electrolyte secretion induced by dibutyryl cyclic AMP in the small intestine

1991 ◽  
Vol 101 (4) ◽  
pp. 1046-1053 ◽  
Author(s):  
Golam H. Rabbani ◽  
Rong-Bao Lu ◽  
Karoly Horvath ◽  
Emanuel Lebenthal
Keyword(s):  
Small Intestine ◽  
Carboxylic Acid ◽  
Cyclic Amp ◽  
Short Chain ◽  
Dibutyryl Cyclic Amp ◽  
Glucose Polymer ◽  
Electrolyte Secretion ◽  
Water And Electrolyte Secretion

The Effect of Nicotinic Acid, 5-Methylpyrazole-3-carboxylic Acid (U-19425), and Dibutyryl Cyclic AMP on Renal Gluconeogenesis

1971 ◽  
Vol 49 (2) ◽  
pp. 102-105
Author(s):  
Andrew Issekutz
Keyword(s):  
Carboxylic Acid ◽  
Cyclic Amp ◽  
Nicotinic Acid ◽  
Kidney Cortex ◽  
Dibutyryl Cyclic Amp ◽  
Renal Gluconeogenesis ◽  
Minimal Concentration ◽  
Cortex Slices ◽  
Glucose Formation ◽  
Kidney Cortex Slices

The effects of nicotinic acid, 5-methylpyrazole-3-carboxylic acid (U-19425), and dibutyryl (DB-) cyclic AMP on gluconeogenesis from lactate, oxalacetate, and glycerol were studied in kidney cortex slices. DB-cyclic AMP stimulated glucose formation from lactate (+67%), but not from oxalacetate or glycerol. Nicotinic acid and U-19425 inhibited gluconeogenesis from all three substrates by 30–63%. DB-cyclic AMP stimulated gluconeogenesis from lactate in the presence of either inhibitor. DB-cyclic AMP abolished the inhibition by either drug on glucose formation from oxalacetate or glycerol. It is concluded that nicotinic acid and U-19425 may inhibit gluconeogenesis by decreasing the cyclic AMP level within the cells, and that a minimal concentration of cyclic AMP may be functional above the triose phosphate level.

Immunochemical visualization of cyclic AMP in myenteric neurons of guinea-pig small intestine+

2001 ◽  
Vol 120 (5) ◽  
pp. A683-A683
Author(s):  
J GUZMAN ◽  
S SHARP ◽  
J YU ◽  
F MCMORRIS ◽  
A WIEMELT ◽  
...  
Keyword(s):  
Small Intestine ◽  
Cyclic Amp ◽  
Guinea Pig ◽  
Myenteric Neurons

The inhibitory effects of some adenosine nucleolipids on the lipolysis in rat epididymal fat pads in vitro

1979 ◽  
Vol 44 (5) ◽  
pp. 1651-1656 ◽  
Author(s):  
Sixtus Hynie ◽  
Jiří Smrt
Keyword(s):  
Fatty Acids ◽  
Cyclic Amp ◽  
Dibutyryl Cyclic Amp ◽  
Inhibitory Effects ◽  
Epididymal Fat ◽  
Fat Pads

3'-Oleolyl-2,3-dihydroxypropyl-AMP, 3'-stearoyl-2,3-dihydroxypropyl-AMP, octadecyl-AMP and palmitamidoethyl-AMP inhibited in comparison with adenosine or fatty acids much stronger the lipolysis in rat epididymal fat pads in vitro stimulated by isoproterenol, theophylline and dibutyryl cyclic AMP. The inhibition of the effects of the two latter drugs suggest that the described effect is caused not only by the inhibition of the cyclic AMP production but also by the inhibition of its effect on the following steps in process of lipolysis.

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