Long-term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth, and gastritis

1993 ◽  
Vol 104 (5) ◽  
pp. 1356-1370 ◽  
Author(s):  
Regina Lamberts ◽  
Werner Creutzfeldt ◽  
Hans G. Strüber ◽  
Gorik Brunner ◽  
Enrico Solcia
Keyword(s):  
Peptic Ulcer ◽  
Cell Growth ◽  
Peptic Ulcer Disease ◽  
Endocrine Cell ◽  
Ulcer Disease

scholarly journals Identification of Markers for Helicobacter pylori Strains Isolated from Children with Peptic Ulcer Disease by Suppressive Subtractive Hybridization

2006 ◽  
Vol 74 (7) ◽  
pp. 4064-4074 ◽  
Author(s):  
Mónica Oleastro ◽  
Lurdes Monteiro ◽  
Philippe Lehours ◽  
Francis Mégraud ◽  
Armelle Ménard
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Subtractive Hybridization ◽  
Suppressive Subtractive Hybridization ◽  
Ulcer Disease ◽  
Lipopolysaccharide Biosynthesis ◽  
The Difference ◽  
H Pylori

ABSTRACT Peptic ulcer disease (PUD) occurs after a long-term Helicobacter pylori infection. However, the disease can develop earlier, and rare cases have been observed in children, suggesting that these H. pylori strains may be more virulent. We used suppressive subtractive hybridization for comparative genomics between H. pylori strains isolated from a 5-year-old child with duodenal ulcer and from a sex- and age-matched child with gastritis only. The prevalence of the 30 tester-specific subtracted sequences was determined on a collection of H. pylori strains from children (15 ulcers and 30 gastritis) and from adults (46 ulcers and 44 gastritis). Two of these sequences, jhp0562 (80.0% versus 33.3%, P = 0.008) and jhp0870 (80.0% versus 36.7%, P = 0.015), were highly associated with PUD in children and a third sequence, jhp0828, was less associated (40.0% versus 10.0%, P = 0.048). Among adult strains, none of the 30 sequences was associated with PUD. However, both jhp0562 and jhp0870 were less prevalent in adenocarcinoma strains than in PUD strains from children and adults, the difference being statistically significant for jhp0870. In conclusion, two H. pylori genes were identified as being strongly associated with PUD in children, and their putative roles as an outer membrane protein for jhp0870 and in lipopolysaccharide biosynthesis for jhp0562, suggest that they may be novel virulence factors of H. pylori.

scholarly journals Predictors of In-Hospital Ambulatory Status Following Low-Energy Hip Fracture Surgery

2019 ◽  
Vol 10 ◽  
pp. 215145931881482 ◽  
Author(s):  
Jordan C. Villa ◽  
Joseph Koressel ◽  
Jelle P. van der List ◽  
Matthew Cohn ◽  
David S. Wellman ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Hip Fracture ◽  
Peptic Ulcer Disease ◽  
Median Time ◽  
Low Energy ◽  
Ulcer Disease ◽  
Time To Surgery ◽  
Ambulatory Status ◽  
Delayed Time

Introduction: Twenty-five percent to seventy-five percent of independent patients do not walk independently after hip fracture (HF), and many patients experience functional loss. Early rehabilitation of functional status is associated with better long-term outcomes; however, predictors of early ambulation after HF have not been well described. Purposes: To assess the impact of perioperative and patient-specific variables on in-hospital ambulatory status following low-energy HF surgery. Methods: This is a retrospective analysis of 463 geriatric patients who required HF surgery at a metropolitan level-1 trauma center. The outcomes were time to transfer (out of bed to chair) and time to walk. Results: Three hundred ninety-two (84.7%) patients were able to transfer after surgery with a median time of 43.8 hours (quartile range: 24.7-53.69 hours), while 244 (52.7%) patients were able to walk with a median time of 50.86 hours (quartile range: 40.72-74.56 hours). Preinjury ambulators with aids (hazard ratio [HR]: 0.70, confidence interval [CI]: 0.50-0.99), age >80 years (HR: 0.66, CI: 0.52-0.84), peptic ulcer disease (HR: 0.57, CI: 0.57-0.82), depression (HR: 0.66, CI: 0.49- 0.89), time to surgery >24 hours (HR: 0.77, CI: 0.61-0.98), and surgery on Friday (HR: 0.73, CI: 0.56-0.95) were associated with delayed time to transfer. Delayed time to walk was observed in patients over 80 years old (HR: 0.74, CI: 0.56-0.98), females (HR: 0.67, CI: 0.48-0.94), peptic ulcer disease (HR: 0.23, CI: 0.84-0.66), and depression (HR: 0.51, CI: 0.33-0.77). Conclusions: Operative predictors of delayed time to transfer were surgery on Friday and time to surgery >24 hours after admission. Depression is associated with delayed time to transfer and time to walk. These data suggest that is important to perform surgeries within 24 hours of admission identify deficiencies in care during the weekends, and create rehabilitation programs specific for patient with depression. Improving functional rehabilitation after surgery may facilitate faster patient discharge, decrease inpatient care costs, and better long-term functional outcomes.

scholarly journals Frequency of osteoporosis in patients with peptic ulcer disease

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Amber Amin ◽  
Qaisar Farooq ◽  
Rizwan Jameel
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Ulcer Disease ◽  
Short And Long Term ◽  
The Common ◽  
The Mean ◽  
Age Range

BACKGROUND & OBJECTIVE: Peptic ulcer disease (PUD) is one of the common presentations in the medical as well as Gastroenterology clinics and it can end up in various short- and long-term complications among which osteoporosis is highly under rated. Therefore, the present study was designed to determine the frequency of osteoporosis in cases having PUD. METHODOLOGY: A cross-sectional study was conducted at the Department of Medicine during 1st January 2020 to 30th June 2020 in Sheikh Zayed Hospital, Lahore. The diagnosed cases of PUD on the basis of history and endoscopic findings with the age range of 20 to 60 years were included. Osteoporosis was labelled as yes, where a T-score of ≤ -2.5 on DEXA scan was noted. RESULTS: In this study, there were a total of 139 cases, out of which 75 (53.95%) were males and 64 (46.05%) females. The mean age of the participants was 48.11±9.43 years. Osteoporosis was observed in 14 (10.07%) out of 139 cases. Osteoporosis was seen in 05 (6.67%) males vs 09 (14.06%) females in their respective groups with p= 0.148. Osteoporosis was observed in 4 (5.80%) cases with a duration of PUD up to 2 years and 10 (14.28%) cases with duration more than this with p= 0.096 CONCLUSION: Osteoporosis is not uncommon in cases with Peptic ulcer disease, and there is no significant association with any of the confounders of this study.

Long-term omeprazole therapy in peptic ulcer disease

1993 ◽  
Vol 105 (6) ◽  
pp. 1924-1925 ◽  
Author(s):  
Regina Lamberts ◽  
Werner Creutzfeldt ◽  
Hans G. Strüber ◽  
Gorik Brunner ◽  
Enrico Solcia
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease

The Long-Term Clinical Outcome of Elderly Patients with Helicobacter pylori-Associated Peptic Ulcer Disease

Gerontology ◽  
1998 ◽  
Vol 44 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Alberto Pilotto ◽  
Marilisa Franceschi ◽  
Francesco Di Mario ◽  
Gioacchino Leandro ◽  
Loredana Bozzola ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Clinical Outcome ◽  
Elderly Patients ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease

scholarly journals Long-term Results of Endoscopic Balloon Dilatation for Gastric Outlet Obstruction Caused by Peptic Ulcer Disease

2019 ◽  
Vol 11 (4) ◽  
pp. 218-224 ◽  
Author(s):  
Ehsan Zare ◽  
Hadi Raeisi ◽  
Behnam Honarvar ◽  
Kamran B. Lankarani
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Balloon Dilatation ◽  
Outlet Obstruction ◽  
Long Term Results ◽  
Current Status ◽  
Ulcer Disease ◽  
Endoscopic Balloon Dilatation ◽  
Endoscopic Balloon

BACKGROUND Gastric outlet obstructions (GOO) is a disabling complication of peptic ulcer disease (PUD). The introduction of endoscopic through the scope balloon dilatation (EBD) has eased the management but there are few reports on the long term results of this modality of treatment on patients’ symptoms. METHODS Over a period of 4 years from January 2012 to December 2015 in two major referral hospitals affiliated to Shiraz university, medical endoscopy reports were reviewed retrospectively to identify those who received EBD for the treatment of GOO due to PUD .All of these patients were recalled and their current status were evaluated. RESULTS 22 consecutive patients with symptomatic GOO secondary to benign stricture underwent endoscopic balloon dilatation by a single operator. Of them, 14 had balloon dilatation twice and 6 had ballooning three times. The interval between the first referral and the last follow-up was 25.2 ± 10.3 (min: 4.8 max:43.4) months. The averages of maximum balloon size were 14.4 ± 5 mm in the first session, 14.3 ± 3.1mm in the second session, and 16 ± 2.4 mm in the third session. 73% of the patients had a significant improvement in clinical symptom with two sessions of EBD and did not require repeat dilatation. CONCLUSION EBD is a safe and efficient method in the management of GOO with good long term results.

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