Differences in bovine aortic smooth muscle cells cultured from spontaneous atherosclerotic lesions of different severity within the same vessel

1984 ◽  
Vol 53 (3) ◽  
pp. 337-342 ◽  
Author(s):  
L. Stavenow
1995 ◽  
Vol 217 (2) ◽  
pp. 280-287 ◽  
Author(s):  
Ottavio Cremona ◽  
Marco Muda ◽  
Ron D. Appel ◽  
Séverine Frutiger ◽  
Graham J. Hughes ◽  
...  

2015 ◽  
Vol 96 (4) ◽  
pp. 359-369 ◽  
Author(s):  
Pranjal Nahar-Gohad ◽  
Neeraj Gohad ◽  
Chen-Chih Tsai ◽  
Rajendra Bordia ◽  
Naren Vyavahare

1991 ◽  
Vol 261 (4) ◽  
pp. 72-77 ◽  
Author(s):  
Marina A. Glukhova ◽  
Boris V. Shekhonin ◽  
Howard Kruth ◽  
Victor E. Koteliansky

An immunofluorescence method was used to study the expression of cytokeratin 8 in human aortic smooth muscle cells (SMCs) during prenatal development and in atherosclerotic plaques. Aortic SMCs from a 10-wk-old fetus contained cytokeratin 8 in additional to vimentin and a small amount of desmin, whereas, in the cells from a 25-wk-old fetus, cytokeratin 8 was not detected. Cytokeratin 8 was found in the SMCs from intimal thickenings, fatty streaks, and atherosclerotic fibrous plaques. Clusters of cytokeratin 8-positive cells were more abundant in rather advanced lesions (fibrous plaques) that contained at least some amount of lipid. Expression of cytokeratin 8 in the cells of human atherosclerotic lesions probably reflects general rearrangement of gene expression in the intimal cells. cytodifferentiation; fetal phenotype; lipid accumulation


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