High-performance liquid chromatography directly coupled to 19F and 1H NMR for the analysis of mixtures of isomeric ester glucuronide conjugates of trifluoromethylbenzoic acids

1996 ◽  
Vol 728 (1-2) ◽  
pp. 377-385 ◽  
Author(s):  
Ulla G. Sidelmann ◽  
Andrew W. Nicholls ◽  
Peter E. Meadows ◽  
John W. Gilbert ◽  
John C. Lindon ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
1H Nmr ◽  
High Performance

Esterification of 5-Norbornene-2,3-Dicarboxylic Anhydride under Titanium Catalyst

2013 ◽  
Vol 634-638 ◽  
pp. 642-646 ◽  
Author(s):  
Sung Ho Park ◽  
Jun Seong Park ◽  
Tae Won Ko ◽  
Yong Sung Park ◽  
Je Wan Woo
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
1H Nmr ◽  
High Performance ◽  
Alder Reaction ◽  
Diels Alder ◽  
Titanium Catalyst ◽  
Light Yellow ◽  
Diels Alder Reaction ◽  
Yield And Purity

Norbornene dicarboxylate was synthesized through esterification under titanium catalyst. The alcohols are 2-ethyl-1-hexanol, n-octanol, 3,5,5-trimethyl-1-hexanol, and n-decanol. The Structures of compounds were identified by 1H-NMR, and then components were identified by high performance liquid chromatography (HPLC). The yield and purity was over 90 % and 95 %, and color of compounds was colorless or light yellow. The maleate as a by-product was occured by the retro Diels-Alder reaction.

scholarly journals Synthesis and HPLC Enantioseparation of Derivatives of the 3-hydroxyphenylethanone

2012 ◽  
Vol 59 (2) ◽  
pp. 15-27
Author(s):  
R. Čižmáriková ◽  
A. Némethy ◽  
J. Valentová ◽  
K. Hroboňová ◽  
K. Bruchatá
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
1H Nmr ◽  
13C Nmr ◽  
High Performance ◽  
Nmr Spectra ◽  
Stationary Phases ◽  
13C Nmr Spectra ◽  
Basic Part ◽  
Derivatives Of

AbstractWithin the framework of the study of the synthesis and high-performance liquid chromatography (HPLC) enantioseparation the series of 9 derivatives of 3-hydroxyphenylethanone was prepared by a well-tried method. The structure of the prepared compounds was confirmed on the basis of interpretation of the IR, UV, 1H NMR and 13C NMR spectra. An enantioseparation of prepared compounds was performed using HPLC on a native teicoplanin (Chirobiotic T) and the amylose tris (3,5-dimethylphenylcarbamate) (Chiralpak AD) chiral stationary phases, which is more suitable for the enantioseparation of all prepared compounds especially with heterocycles in the basic part of a molecule.

scholarly journals Synthesis of new compounds of the aryloxyaminopropanol type and their HPLC enantioseparation

2013 ◽  
Vol 60 (2) ◽  
pp. 37-42
Author(s):  
Čižmáriková R. ◽  
Némethy A. ◽  
Valentová J. ◽  
Hroboňová K. ◽  
Adamcová K.
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
1H Nmr ◽  
13C Nmr ◽  
High Performance ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
Thinlayer Chromatography ◽  
New Compounds

Abstract This article describes a preparation of some new compounds of the aryloxyaminopropanol type derived from 4-hydroxyphenylpropan- 1-one with phenylamino, cyclohexylamino and isobutylamino group in the hydrophilic part and methoxymethyl or ethoxymethyl substituent in the lipophilic part of the molecule. The purity of the prepared compounds was checked by thinlayer chromatography and the structure was confirmed on the basis of interpretation of the IR, UV, 1H NMR and 13C NMR spectra. An enantioseparation of the prepared compounds was performed by using high-performance liquid chromatography on an amylase tris(3,5-dimethylphenylcarbamate) (Chiralpak AD) and native teicoplanin (Chirobiotic T). The chromatographic results such as retention, separation and resolution factors have shown that Chiralpak AD is more suitable for enantioseparation of some of the prepared compounds.

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