Crystallization and preliminary X-ray diffraction study of the heat-labile enterotoxin B subunit produced by enterotoxigenic Escherichia coli

1989 ◽  
Vol 208 (1) ◽  
pp. 207-208 ◽  
Author(s):  
Takao Tsuji ◽  
Keiichi Fukuyama ◽  
Hiroshi Matsubara ◽  
Takeshi Honda ◽  
Toshio Miwatani
Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101099
Author(s):  
Amir Namvar Vansofla ◽  
Shahram Nazarian ◽  
Emad Kordbache ◽  
Javad Fathi

2010 ◽  
Vol 72 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Nguyen Hoang Loc ◽  
Nguyen Hoang Bach ◽  
Tae-Geum Kim ◽  
Moon-Sik Yang

2001 ◽  
Vol 69 (5) ◽  
pp. 3476-3482 ◽  
Author(s):  
Douglas G. Millar ◽  
Timothy R. Hirst ◽  
Denis P. Snider

ABSTRACT Although cholera toxin (Ctx) and Escherichia coliheat-labile enterotoxin (Etx) are known to be potent mucosal adjuvants, it remains controversial whether the adjuvanticity of the holotoxins extends to their nontoxic, receptor-binding B subunits. Here, we have systematically evaluated the comparative adjuvant properties of highly purified recombinant EtxB and CtxB. EtxB was found to be a more potent adjuvant than CtxB, stimulating responses to hen egg lysozyme when the two were coadministered to mice intranasally, as assessed by enhanced serum and secretory antibody titers as well as by stimulation of lymphocyte proliferation in spleen and draining lymph nodes. These results indicate that, although structurally very similar, EtxB and CtxB have strikingly different immunostimulatory properties and should not be considered equivalent as prospective vaccine adjuvants.


2006 ◽  
Vol 121 (2) ◽  
pp. 124-133 ◽  
Author(s):  
Tae-Jin Kang ◽  
Won-Seok Lee ◽  
Eun-Gyung Choi ◽  
Jae-Whune Kim ◽  
Bang-Geul Kim ◽  
...  

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