The relationship between obsessive–compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study

2001 ◽  
Vol 31 (3) ◽  
pp. 481-487 ◽  
Author(s):  
G. NESTADT ◽  
J. SAMUELS ◽  
M. A. RIDDLE ◽  
K.-Y. LIANG ◽  
O. J. BIENVENU ◽  
...  

Objective. This study investigates the relationship of specific anxiety and affective disorders to obsessive–compulsive disorder (OCD) in a blind, controlled family study.Method. Eighty case and 73 control probands, as well as 343 case and 300 control first-degree relatives of these probands, participated in the study. Subjects were examined by psychologists or psychiatrists using the Schedule for Affective Disorder and Schizophrenia-Lifetime Anxiety version (SADS-LA). Two experienced psychiatrists independently reviewed all clinical materials, and final diagnoses were made according to DSM-IV criteria, by consensus procedure.Results. Except for bipolar disorder, all anxiety and affective disorders investigated were more frequent in case than control probands. Substance dependence disorders were not more frequent. Generalized anxiety disorder (GAD), panic disorder, agoraphobia, separation anxiety disorder (SAD) and recurrent major depression were more common in case than control relatives. These disorders occurred more frequently if the relative was diagnosed with OCD. Only GAD and agoraphobia were more frequent in case relatives independent of OCD.Conclusion. GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome.

2008 ◽  
Vol 39 (9) ◽  
pp. 1491-1501 ◽  
Author(s):  
G. Nestadt ◽  
C. Z. Di ◽  
M. A. Riddle ◽  
M. A. Grados ◽  
B. D. Greenberg ◽  
...  

BackgroundObsessive–compulsive disorder (OCD) is probably an etiologically heterogeneous condition. Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes.MethodSeven hundred and six individuals with OCD were assessed in the OCD Collaborative Genetics Study (OCGS). Multi-level latent class analysis was conducted based on the presence of eight co-morbid psychiatric conditions [generalized anxiety disorder (GAD), major depression, panic disorder (PD), separation anxiety disorder (SAD), tics, mania, somatization disorders (Som) and grooming disorders (GrD)]. The relationship of the derived classes to specific clinical characteristics was investigated.ResultsTwo and three classes of OCD syndromes emerge from the analyses. The two-class solution describes lesser and greater co-morbidity classes and the more descriptive three-class solution is characterized by: (1) an OCD simplex class, in which major depressive disorder (MDD) is the most frequent additional disorder; (2) an OCD co-morbid tic-related class, in which tics are prominent and affective syndromes are considerably rarer; and (3) an OCD co-morbid affective-related class in which PD and affective syndromes are highly represented. The OCD co-morbid tic-related class is predominantly male and characterized by high conscientiousness. The OCD co-morbid affective-related class is predominantly female, has a young age at onset, obsessive–compulsive personality disorder (OCPD) features, high scores on the ‘taboo’ factor of OCD symptoms, and low conscientiousness.ConclusionsOCD can be classified into three classes based on co-morbidity. Membership within a class is differentially associated with other clinical characteristics. These classes, if replicated, should have important implications for research and clinical endeavors.


1998 ◽  
Vol 26 (3) ◽  
pp. 307-316 ◽  
Author(s):  
Peter Muris ◽  
Harald Merckelbach ◽  
Birgit Mayer ◽  
Nienke Snieder

The current study examined the relationship between anxiety disorder symptoms and negative self-statements in a sample of normal children (N=119). Children were asked to complete the Screen for Child Anxiety Related Emotional Disorders (SCARED) and the Negative Affect Self-Statement Questionnaire (NASSQ). Results showed that, in normal children, there is a positive relationship between anxiety disorder symptoms, as indexed by the SCARED, and negative self-statements, as measured by the NASSQ. In particular, anxious self-statements were more often present in children who exhibited relatively high levels of anxiety symptoms. Furthermore, depressive and anxiousdepressive self-statements were found to be positively associated with the presence of symptoms of generalized anxiety disorder, obsessive-compulsive disorder, separation anxiety disorder, and panic disorder.


2001 ◽  
Vol 31 (7) ◽  
pp. 1307-1310 ◽  
Author(s):  
R. GOODWIN ◽  
J. D. LIPSITZ ◽  
T. F. CHAPMAN ◽  
S. MANNUZZA ◽  
A. J. FYER

Background. This study was undertaken to examine the relationship between anxiety co-morbidity and age of onset of panic disorder.Methods. Age of onset of panic disorder and co-morbid anxiety disorders were assessed among 201 panic disorder probands with childhood separation anxiety disorder, obsessive–compulsive disorder, obsessive–compulsive symptoms, social phobia and specific phobia as part of a clinician-administered lifetime diagnostic interview. A generalized linear model was used to test the association between each anxiety co-morbidity and age of panic disorder onset while simultaneously controlling for the potential confounding effects of sociodemographic characteristics and other psychiatric co-morbidity.Results. Earlier onset of panic disorder was found in patients with co-morbid obsessive–compulsive disorder, obsessive–compulsive symptoms and separation anxiety disorder, but not simple phobia or social phobia. Patients with both childhood separation anxiety disorder and obsessive–compulsive disorder had an even earlier panic onset than those with either childhood separation anxiety disorder or obsessive–compulsive disorder.Conclusions. The association between anxiety co-morbidity and earlier onset of panic disorder is specific to obsessive–compulsive disorder and childhood separation anxiety disorder.


2015 ◽  
Vol 30 (1) ◽  
pp. 145-151 ◽  
Author(s):  
A.P. Franz ◽  
L. Rateke ◽  
T. Hartmann ◽  
N. McLaughlin ◽  
A.R. Torres ◽  
...  

AbstractObjective:Individuals with obsessive-compulsive disorder (OCD) and separation anxiety disorder (SAD) tend to present higher morbidity than do those with OCD alone. However, the relationship between OCD and SAD has yet to be fully explored.Method:This was a cross-sectional study using multiple logistic regression to identify differences between OCD patients with SAD (OCD + SAD, n = 260) and without SAD (OCD, n = 695), in terms of clinical and socio-demographic variables. Data were extracted from those collected between 2005 and 2009 via the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders project.Results:SAD was currently present in only 42 (4.4%) of the patients, although 260 (27.2%) had a lifetime diagnosis of the disorder. In comparison with the OCD group patients, patients with SAD + OCD showed higher chance to present sensory phenomena, to undergo psychotherapy, and to have more psychiatric comorbidities, mainly bulimia.Conclusion:In patients with primary OCD, comorbid SAD might be related to greater personal dysfunction and a poorer response to treatment, since sensory phenomena may be a confounding aspect on diagnosis and therapeutics. Patients with OCD + SAD might be more prone to developing specific psychiatric comorbidities, especially bulimia. Our results suggest that SAD symptom assessment should be included in the management and prognostic evaluation of OCD, although the psychobiological role that such symptoms play in OCD merits further investigation.


2009 ◽  
Vol 58 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Isabella G. S. de Souza ◽  
Maria Antonia Serra-Pinheiro ◽  
Renata Mousinho ◽  
Paulo Mattos

OBJETIVE: The advance of research in child and adolescent psychiatry in Brazil heavily depends on the existence of instruments for the investigation of psychiatric syndromes adapted to Brazilian Portuguese. METHODS: This article describes a careful process of translation of the Children's Interview for Psychiatric Syndromes for the purpose of use in research in Brazil. The Children's Interview for Psychiatric Syndromes has a version for parents (P-ChIPs) and a version for children (ChIPS). In this article, the sections of P-ChIPS referring to attention-deficit hyperactivity disorder, oppositional-defiant disorder, conduct disorder, mania/hypomania, anorexia nervosa, bulimia nervosa and psychotic disorders were translated to Brazilian Portuguese. The sections of the ChIPS referring to substance use disorders, social anxiety disorder, specific phobias, obsessive-compulsive disorder, generalized anxiety disoder, separation anxiety disorder, post-traumatic disorders and depression/dysthimia were also adapted. Each section was translated by two independent translators and later discussed in a committee composed of experts in the field of Psychiatry and a professional of the field of linguistics. RESULT: A final version containing an interview for the main psychiatric syndromes was defined. CONCLUSION: The translated P-ChIPS is a helpful instrument in children and adolescent clinical evaluation.


2018 ◽  
Vol 7 (1) ◽  
pp. 40-45
Author(s):  
B.S. Gurung ◽  
M. Rana ◽  
S. Shakya

Introduction: The study has examined the psycho-metric properties of the Nepali translation of SCAS-PV in terms of internal consistency and criterion validity Material and Method: Non probability sampling method was used. Participants were selected purposively under two groups of samples called clinical group and non clinical group. Study population of the study was the patient visiting outdoor and inpatient services of Department of Psychiatry and Mental Health, TUTH. Results: Among 200 (clinical= 98 and a non-clinical=102) sample of Nepalese children and adolescents. The specificity and sensitivity of the tool was assessed. Cronbach Alpha for the total scale (α =0.89), panic disorder (α =0.78), physical injury fear (α =0.72) and separation anxiety disorder (α =0.76) were of acceptable to good range. However, internal consistency of generalized anxiety disorder (α =0.67), obsessive compulsive disorder (α =0.59) and social anxiety disorder (α =0.68) were in questionable range. AUC statistic for total scale was in fair range, with optimum cut off score of 19.5 for the total scale with sensitivity of 65.3% and specificity of 64.7%. Conclusion: The study supports the utility of the SCAS-PV as a measure of anxiety symptoms in children. It can be used to directly compare symptom reporting across children in clinical. Because of the psychometric properties of the SCAS-PV that have been demonstrated in community and clinical samples, it is recommended that the SCAS-PV can be used in clinical and research contexts.


Author(s):  
Sherva Cooray ◽  
Avinash Hiremath

This chapter provides an overview of anxiety and related disorders including, generalized anxiety disorder, panic disorder, agoraphobia, specific phobia, social anxiety disorder, separation anxiety disorder, hypochondriasis, obsessive compulsive disorder (OCD) and post traumatic stress disorder (PTSD). It covers the diagnosis, clinical features, epidemiology, aetiology, pathophysiology, risk factors, treatment, and prognosis. Due to the cognitive limitations and needs profile of people with intellectual disabilities (ID), the diagnosis of these conditions is particularly challenging, due to which they are under-recognized and poorly treated. The approaches to management are largely modelled on treatment models used in the mainstream populations without ID, although these models have to be adapted appropriately to the needs of the individual’s psychological, biological, and social circumstances.


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