Leukotriene synthesis inhibition and anti-ige challenge of human lung parenchyma

Life Sciences ◽  
1996 ◽  
Vol 59 (13) ◽  
pp. PL213-PL219
Author(s):  
I. Gorenne ◽  
H.Sosse Alaoui ◽  
J.P. Gascard ◽  
C. Labat ◽  
X. Norel ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Parenchyma ◽  
Synthesis Inhibition

Microscopic vs. macroscopic deformation of the pulmonary alveolar duct

1992 ◽  
Vol 72 (4) ◽  
pp. 1348-1354 ◽  
Author(s):  
D. Yager ◽  
H. Feldman ◽  
Y. C. Fung
Keyword(s):  
Human Lung ◽  
Lung Parenchyma ◽  
Stretch Ratio ◽  
Area Ratio ◽  
Force Balance ◽  
Load Carrying ◽  
Macroscopic Deformation ◽  
Alveolar Duct ◽  
Deformed State ◽  
Length And Area

The stretch of the perimeters of alveolar ducts was measured at the surface of saline-filled specimens of human and dog lung parenchyma that were stretched biaxially. The microscopic stretch of these ducts was measured at several levels of isotropic biaxial macroscopic stretch of the parenchyma with stretch ratio (lambda x = lambda y) in the range of 1.20–1.40, which roughly corresponds to tidal breathing in humans and dogs. Alveolar walls were found to be load-carrying elements in the saline-filled lung, as seen by their straightness at all levels of stretch. Quantitatively, let l, A, L, and S denote, respectively, the duct perimeter length and area and the parenchymal target perimeter and area in the deformed state and lo, Ao, Lo, and So the corresponding variables in the undeformed state. The microscopic stretch ratio of the ducts (l/lo) was found to be approximately 4% larger than the macroscopic stretch ratio (L/Lo) in human lung and approximately 10% larger in dog lung. The microscopic area ratio of the ducts (A/Ao) was found to be approximately 10% larger than the macroscopic area ratio (S/So) in human lung and approximately 22% larger in dog lung. Ducts within human parenchyma were seen to be about twice as stiff as ducts within dog parenchyma over the range of macroscopic stretch studied. This correlates with the volume fractions of collagen and elastin being higher in the human lung than in dog lung. The observed nonuniformity in strain field at the microstructural level suggests the need to include a force balance between alveolar ducts and septal walls when modeling the mechanics of saline-filled parenchyma.

Immune Response to Peptides Produced by Enzymatic Digestion of Microfibrils And Elastin of Human Lung Parenchyma

1977 ◽  
Vol 5 (2) ◽  
pp. 67-73 ◽  
Author(s):  
Tukaram V. Darnule ◽  
Vinay Likhite ◽  
Gerard M. Turino ◽  
Ines Mandl
Keyword(s):  
Immune Response ◽  
Human Lung ◽  
Lung Parenchyma ◽  
Enzymatic Digestion

Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced TGF-β Signaling and α-SMA Expression

2010 ◽  
Vol 43 (6) ◽  
pp. 641-651 ◽  
Author(s):  
Dmitri V. Pechkovsky ◽  
Tillie L. Hackett ◽  
Steven S. An ◽  
Furquan Shaheen ◽  
Lynne A. Murray ◽  
...  
Keyword(s):  
Human Lung ◽  
Lung Parenchyma

Mononuclear Cells in Human Lung Parenchyma: Characterization of a Potent Accessory Cell Not Obtained by Bronchoalveolar Lavage

1987 ◽  
Vol 136 (4) ◽  
pp. 818-823 ◽  
Author(s):  
Laurent P. Nicod ◽  
Mary F. Lipscomb ◽  
Jonathan C. Wiessler ◽  
C. Richard Lyons
Keyword(s):  
Bronchoalveolar Lavage ◽  
Mononuclear Cells ◽  
Human Lung ◽  
Lung Parenchyma ◽  
Accessory Cell

Ascorbic acid promotes prostanoid release in human lung parenchyma

1986 ◽  
Vol 31 (2) ◽  
pp. 361-368 ◽  
Author(s):  
Yeong-Dar Fann ◽  
Karen G. Rothberg ◽  
P.Glenn Tremml ◽  
James S. Douglas ◽  
A.B. DuBois
Keyword(s):  
Ascorbic Acid ◽  
Human Lung ◽  
Lung Parenchyma

scholarly journals Characterisation of a high-affinity VIP receptor in human lung parenchyma

FEBS Letters ◽  
1986 ◽  
Vol 199 (1) ◽  
pp. 125-129 ◽  
Author(s):  
M. Schachter ◽  
K.E.J. Dickinson ◽  
C.M. Miles ◽  
P.S. Sever
Keyword(s):  
Human Lung ◽  
Lung Parenchyma ◽  
High Affinity ◽  
Vip Receptor

The Contributions Of Analytical Electron Microscopy to the Detection and Quantification of Asbestos in Human Lung Samples

1990 ◽  
Vol 48 (2) ◽  
pp. 340-341
Author(s):  
Victor L. Roggli
Keyword(s):  
Electron Microscopy ◽  
Human Lung ◽  
Analytical Electron Microscopy ◽  
Lung Parenchyma ◽  
Chrysotile Asbestos ◽  
Mineral Fiber ◽  
Pleural Plaques ◽  
Analytical Electron ◽  
The Relationship ◽  
Detection And Quantification

Analytical electron microscopy has contributed a great deal to our understanding of asbestosrelated diseases. Exposure to the various forms of asbestos, which include the serpentine form known as chrysotile asbestos, and the amphibole forms referred to as amosite, crocidolite, tremolite, anthophyllite, and actinolite asbestos, has been associated with the development of a number of diseases in man. These include asbestosis (scarring of the lung parenchyma), pleural plaques (scarring of the pleura), malignant mesothelioma of the pleura and peritoneum, and carcinoma of the lung, especially among those who also smoke cigarettes.Analysis of the mineral fiber content of the lung in patients with these various diseases has provided a powerful investigative tool to researchers interested in the relationship between fiber burdens and disease. Such studies have shown that when sufficiently sensitive digestion concentration techniques are employed, some asbestos can be found in lung tissue from virtually every adult in the general population.

Sign in / Sign up

Export Citation Format

Share Document