Effect of aminoglutehimide and reserpine on the human pituitary-adrenal axis: Remission of a case of Cushing's disease

Metabolism ◽  
1970 ◽  
Vol 19 (10) ◽  
pp. 818-830 ◽  
Author(s):  
James R. Givens ◽  
Alvro Camacho ◽  
Phillip Patterson
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Varicella causing remission of Cushing’s disease

2018 ◽  
pp. bcr-2018-225867
Author(s):  
Henith Raj ◽  
Sadishkumar Kamalanathan ◽  
Jaya Prakash Sahoo ◽  
Tamilarasu Kadhiravan
Keyword(s):  
Adrenal Insufficiency ◽  
Cushing’S Disease ◽  
Pituitary Apoplexy ◽  
Cushing's Disease ◽  
Varicella Infection ◽  
Persistent Vomiting ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Hormonal Evaluation ◽  
Pituitary Adrenal Axis

An 18-year-old male with Cushing’s disease presented with generalised skin eruptions and backache. He was diagnosed with varicella infection. During the course of the illness, he developed persistent vomiting. Hormonal evaluation suggested adrenal insufficiency. MRI of brain showed features of pituitary apoplexy. Initially, he required hydrocortisone replacement. Later on his hypothalamic–pituitary–adrenal axis recovered and he is currently asymptomatic without any treatment.

scholarly journals Molecular-metabolic interaction of pituitary-adrenal axis with adrenocorticotropic and glucocorticoid hormone in Cushing’s disease

2021 ◽  
Author(s):  
Jie Ding ◽  
Ming Feng ◽  
Marcus Hacker ◽  
Li Huo ◽  
Xiang Li
Keyword(s):  
Glucose Metabolism ◽  
Cushing’S Disease ◽  
Fdg Pet ◽  
Pituitary Adenomas ◽  
Cushing's Disease ◽  
Molecular Signaling ◽  
Adrenal Axis ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Pituitary Adrenal Axis

Abstract Purpose This study aimed to investigate C-X-C motif chemokine receptor 4 (CXCR4) molecular signaling pathway and the glucose metabolism of pituitary-adrenal axis in Cushing’s disease (CD) by using 68Ga-pentixafor and 18F-FDG PET/CT. Methods We recruited eleven patients including 4 primary CD, 3 recurrent CD and 4 non-functional pituitary adenoma (NFPA) patients. Both 68Ga-pentixafor PET/CT and 18F-FDG PET/CT were performed. The radio-uptake of pituitary-adrenal axis was correlated with the hormone levels (including serum adrenocorticotropin, serum cortisol and 24-h urine free cortisol). Results The uptake of pituitary adenomas and bilateral adrenals in primary and recurrent CD patients were significantly higher than NFPA patients in 68Ga-pentixafor PET. Besides, hormone level was significantly correlated with the uptake of 68Ga-pentixafor in pituitary adenomas and adrenal tissue but not with glucose metabolism determined by 18F-FDG PET. Conclusions In this pilot study, we found activated CXCR4 molecular signaling rather than glucose metabolism regulation along the pituitary-adrenal axis in CD patients. 68Ga-pentixafor PET/CT might have the potential in detecting ACTH-producing pituitary microadenoma.

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Can we cure Cushing’s disease? A personal view

2018 ◽  
Vol 178 (5) ◽  
pp. R183-R200 ◽  
Author(s):  
X Bertagna
Keyword(s):  
Pituitary Adenoma ◽  
Cushing’S Disease ◽  
Pituitary Surgery ◽  
Cushing's Disease ◽  
Therapeutic Approaches ◽  
Personal View ◽  
Endocrine Disease ◽  
Adrenal Axis ◽  
Default Options ◽  
Pituitary Adrenal Axis

One of today’s challenges in endocrinology is the treatment of Cushing’s disease: Although pituitary surgery has the potential to ‘cure’ the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences that will ultimately require alternate therapeutic approaches. Their high number is in direct correlation with their serious limitations and they all appear to be ‘default options’. This ‘personal view’ tries to shed some light on the inescapable difficulties of the current treatments of Cushing’s disease and to provide some optimistic view for the future where the pituitary adenoma should be the ‘reasonable obsession’ of a successful therapeutist.

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

TISSUE CULTURE STUDIES ON HUMAN PITUITARY TUMOURS: RADIOIMMUNOASSAYABLE ANTERIOR PITUITARY HORMONES IN THE CULTURE MEDIUM

1978 ◽  
Vol 88 (2) ◽  
pp. 239-249 ◽  
Author(s):  
Loren G. Lipson ◽  
Inese Z. Beitins ◽  
Paul D. Kornblith ◽  
Janet W. Mc Arthur ◽  
Henry G. Friesen ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Cushing’S Disease ◽  
Anterior Pituitary ◽  
Pituitary Hormones ◽  
Cushing's Disease ◽  
Hormone Release ◽  
Pituitary Tumours ◽  
Human Pituitary ◽  
Anterior Pituitary Hormones

ABSTRACT A tissue culture study was undertaken to determine if human non-functioning pituitary tumours secrete polypeptide anterior pituitary hormones in vitro and to study the spectrum of hormone release by functioning pituitary neoplasms. Fragments from 48 human pituitary tumours (from patients - 2 with Cushing's disease, 1 with Nelson's syndrome, 5 with amenorrhoea-galactorrhoea, 10 with acromegaly and 30 with non-functioning pituitary tumours) and three normal human anterior pituitary glands (controls) were placed in tissue culture immediately after surgery. The in vitro release of human growth hormone (HGH), prolactin (Prl), thyrotrophin (TSH), adrenocorticotrophin (ACTH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured by radioimmunoassays at the end of one week in culture. Clinical and pathological data were compared to hormone release patterns. In the culture media from control pituitaries the concentrations of the six hormones tested were 100 to 10 000 times greater than in peripheral blood. The medium surrounding the fragments from functioning pituitary tumours contained the following: a) Acromegaly - high levels of HGH and variable concentrations of the other hormones. b) Cushing's disease - ACTH and Prl predominantly. c) Amenorrhcea-galactorrhoea syndrome - prolactin in 4 out of 5 patients, all six polypeptides in one patient. In the media from the 30 patients diagnosed as having non-functioning pituitary tumours, 60 % of the samples contained at least one hormone at a concentration similar to that of the controls and 100 % of the samples contained detectable quantities of at least one hormone.

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