Significant effect of ABO blood groups on the aggregation of red cells in patients with diabetes mellitus role of fibrinogen and serum proteins

Abstract An up-dated survey of the information pertaining to the role of genetic factors in susceptibility to multiple myeloma is attempted. Our own results include the HLA-A, B, and C types in 68 patients, the G1m and Km allotypes in 86 patients, and the frequencies of ABO blood groups in 126 patients with multiple myeloma. The allotype G1m(x) was significantly (p less than 0.05) more frequent in the patient group. Since the results in the literature on a possible HLA association have been inconsistent, all relevant available data were combined for an assessment of 379 patients versus 5041 controls. In this comparatively large patient group, the previously reported increase of HLA-4c (HLA-B5 + B18 + Bw35) complex could be confirmed and identified as a weak (RR = 1.7) but significant (p less than 0.05) association of susceptibility to multiple myeloma with HLA-B5. Evaluation of G1m allotypes in the combined sample of 258 patients and 4550 controls and Km in 179 and 2457, respectively yielded no significant differences.

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Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat

Current Drug Targets ◽

10.2174/1389450122666210120125945 ◽

2021 ◽

Vol 22 ◽

Author(s):

Raghuvir Keni ◽

Abinitha Sekhar ◽

Karthik Gourishetti ◽

Pawan Ganesh Nayak ◽

Manas Kinra ◽

...

Keyword(s):

Diabetes Mellitus ◽

Meta Analysis ◽

Primary And Secondary Prevention ◽

Patients With Diabetes ◽

Peripheral Cells ◽

Intensive Statin Therapy ◽

New Onset Diabetes Mellitus ◽

Analysis Point ◽

New Onset

Statins have transformed the treatment of cardiovascular diseases through primary and secondary prevention of events. Despite the success of statin's inefficient management of cardiovascular conditions, certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to induce diabetes. The risk further increases with intensive statin therapy or in with patients with diabetes. A proper mechanism for the induction of the diabetic condition has not yet been determined. The involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance has been widely studied and established. The present review provides an update on recent understanding of statin-induced diabetes. This covers the origin of statins, their development, possible mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to remedy the condition.

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Recovery of Blood Group Antibodies from Erythrocyte Powder

Blood ◽

10.1182/blood.v14.8.913.913 ◽

1959 ◽

Vol 14 (8) ◽

pp. 913-919

Author(s):

FELIX MILGROM ◽

CARLOS ORELLANA ◽

MIGUEL LAYRISSE

Keyword(s):

Blood Group ◽

Antibody Production ◽

Human Erythrocyte ◽

Blood Groups ◽

Natural Antibodies ◽

Red Cells ◽

Abo Blood Groups ◽

Negative Finding

Abstract A powder from dried human erythrocyte stromata was prepared to determine whether normal autoantibodies could be recovered from unsensitized erythrocyte powder and to study some of the properties of anti-A, anti-B and anti-Rho(D) antibodies recovered from sensitized powder. Twenty-five samples of unsensitized erythrocyte powder of all ABO blood groups were tested. The amount of eluted powder was as great as 200 mg., representing about 25 ml. of packed red cells. In no instance could antibody be detected in the eluates. This negative finding could be explained in three ways: by lack of antibody production, in disagreement with Landsteiner’s rule; by neutralization of antibody by a corresponding antigen before it reached the circulation; or by immediate elimination of sensitized erythrocytes from the circulation. The eluate of A erythrocyte powder sensitized with O serum agglutinated both A and B red cells. After neutralization with A polysaccharides, the anti-A antibody disappeared and anti-B remained. These experiments appear to support the theory of the multispecific character of natural antibodies. Rh-positive erythrocyte powder was sensitized with an incomplete anti-D (anti-Rho) serum and eluted in saline. The eluate did not agglutinate Rhpositive cells, but sensitized them for the action of Coombs’ serum. The mixture of Coombs’ serum with the eluate also produced agglutination of Rh-positive cells. These phenomena are explained as being due to the lack of or the very small amount of ballast proteins in the saline eluate.

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