Genetic injury in hybrid male mice exposed to low doses of 60Co γ-rays or fission neutrons III. Frequencies of abnormal sperm and reciprocal translocations measured during and following long-term weekly exposures

1988 ◽  
Vol 198 (2) ◽  
pp. 285-294 ◽  
Author(s):  
D. Grahn ◽  
B.A. Carnes
Keyword(s):  
Low Doses ◽  
Male Mice ◽  
Hybrid Male ◽  
Reciprocal Translocations ◽  
Abnormal Sperm ◽  
Γ Rays ◽  
Fission Neutrons

Life Shortening in Mice Exposed to Fission Neutrons and γ Rays: II. Duration-of-Life and Long-Term Fractionated Exposures

1981 ◽  
Vol 86 (3) ◽  
pp. 573 ◽  
Author(s):  
John F. Thomson ◽  
Frank S. Williamson ◽  
Douglas Grahn ◽  
E. John Ainsworth
Keyword(s):  
Γ Rays ◽  
Fission Neutrons

scholarly journals Lung Carcinomas in Sprague-Dawley Rats after Exposure to Low Doses of Radon Daughters, Fission Neutrons, or γ Rays

1989 ◽  
Vol 118 (2) ◽  
pp. 230 ◽  
Author(s):  
J. Lafuma ◽  
D. Chmelevsky ◽  
J. Chameaud ◽  
M. Morin ◽  
R. Masse ◽  
...  
Keyword(s):  
Low Doses ◽  
Sprague Dawley ◽  
Lung Carcinomas ◽  
Sprague Dawley Rats ◽  
Radon Daughters ◽  
Γ Rays ◽  
Fission Neutrons

scholarly journals Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model

Metabolites ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 252
Author(s):  
Maarisha Upadhyay ◽  
Meena Rajagopal ◽  
Kirandeep Gill ◽  
Yaoxiang Li ◽  
Shivani Bansal ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Low Dose ◽  
Acid Metabolism ◽  
Space Radiation ◽  
Low Doses ◽  
Oxygen Ions ◽  
Inflammatory Phenotype ◽  
Γ Rays ◽  
High Linear Energy Transfer

Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (16O) and protons (1H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.

Life Shortening in Mice Exposed to Fission Neutrons and γ Rays: V. Further Studies with Single Low Doses

1985 ◽  
Vol 104 (3) ◽  
pp. 420 ◽  
Author(s):  
John F. Thomson ◽  
Frank S. Williamson ◽  
Douglas Grahn
Keyword(s):  
Low Doses ◽  
Γ Rays ◽  
Fission Neutrons

The Fine Structure of Irradiated Mouse Heart

1976 ◽  
Vol 34 ◽  
pp. 184-185
Author(s):  
Vivian V. Yang ◽  
S. Phyllis Stearner
Keyword(s):  
Microscopic Level ◽  
Ultrastructural Changes ◽  
Mouse Heart ◽  
Blood Vessel Wall ◽  
Histopathological Changes ◽  
Light Microscopic Level ◽  
Γ Rays ◽  
Fission Neutrons ◽  
Total Body

The heart is generally considered a radioresistant organ, and has received relatively little study after total-body irradiation with doses below the acutely lethal range. Some late damage in the irradiated heart has been described at the light microscopic level. However, since the dimensions of many important structures of the blood vessel wall are submicroscopic, investigators have turned to the electron microscope for adequate visualization of histopathological changes. Our studies are designed to evaluate ultrastructural changes in the mouse heart, particularly in the capillaries and muscle fibers, for 18 months after total-body exposure, and to compare the effects of 240 rad fission neutrons and 788 rad 60Co γ-rays.Three animals from each irradiated group and three control mice were sacrificed by ether inhalation at 4 days, and at 1, 3, 6, 12, and 18 months after irradiation. The thorax was opened and the heart was fixed briefly in situwith Karnofsky's fixative.

Sign in / Sign up

Export Citation Format

Share Document