Analysis of the analgesic efficacy and cost-effective use of long-acting local anesthetics in outpatient third molar surgery

Aim: To compare the analgesic efficacy of a single dose preoperative intramuscular Ketorolac versus diclofenac sodium forprevention of postoperative pain after third molar surgery. Design: This Experimental comparative study. Setting: Department of Anesthesia,Pakistan Atomic Energy Commission, Al-Zahra Hospital, Geo Care, and Maryam Maternity Hospital, DG Khan. Period: October 2011 to March2012. Material and Method: Patients undergoing elective third molar surgery were randomly assigned into one of the two groups. In eachgroup, 60 patients completed the study properly. Group-I received diclofenac sodium 75 mg IM 20 min preoperatively and group-II receivedKetorolac 30 mg IM 20 min preoperatively. Result: Patient in Ketorolac group reported significantly lesser pain intensity scores in the 3rd hourpain than the Diclofenac group (p-value lesser than 0.0001). Patient also reported significantly longer mean time to rescue analgesic 7.5 hversus 4.8h (p lesser than 0.001., student t test) that is approximately 2.5 h longer duration of preventive analgesic consumption (p=0.006,student t test). Conclusions: Preoperative intramuscular injection of Ketorolac 30 mg is more effective than Diclofenac 75 mg in the preventionof post operative 3rd molar pain.

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A Double-blind, Placebo-controlled, Randomized Comparison of Analgesic Efficacy of Oral Ketorolac Versus Intramuscular Tramadol After Third Molar Surgery

International Journal of Pharmaceutical Investigation ◽

10.5530/ijpi.2020.4.102 ◽

2020 ◽

Vol 10 (4) ◽

pp. 586-589

Author(s):

Fazil Arshad Nasyam

Keyword(s):

Third Molar ◽

Analgesic Efficacy ◽

Third Molar Surgery ◽

Double Blind ◽

Double Blind Placebo

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Double-blind, randomized controlled clinical trial on analgesic efficacy of local anesthetics articaine and bupivacaine after impacted third molar extraction

Clinical Oral Investigations ◽

10.1007/s00784-018-2386-1 ◽

2018 ◽

Vol 22 (9) ◽

pp. 2981-2988 ◽

Cited By ~ 2

Author(s):

Maria Victoria Olmedo-Gaya ◽

Francisco Javier Manzano-Moreno ◽

Jose Luis Muñoz-López ◽

Manuel Francisco Vallecillo-Capilla ◽

Candela Reyes-Botella

Keyword(s):

Clinical Trial ◽

Local Anesthetics ◽

Third Molar ◽

Analgesic Efficacy ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Double Blind ◽

Impacted Third Molar ◽

Randomized Controlled ◽

Third Molar Extraction

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Evaluation of efficacy of submucosal tramadol after mandibular third molar surgery: a prospective pilot study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20195009 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4320

Author(s):

Karan V. Panchal ◽

Navin S. Shah ◽

Pratik Agrawal ◽

Parshwa N. Shah

Keyword(s):

Pilot Study ◽

Maxillofacial Surgery ◽

Third Molar ◽

Mouth Opening ◽

Analgesic Efficacy ◽

Third Molar Surgery ◽

Oral And Maxillofacial Surgery ◽

Third Molar Extraction ◽

Mandibular Third Molar ◽

Surgical Extraction

Background: Surgical extraction of mandibular third molar is one of the most commonly performed procedure in oral and maxillofacial surgery. Its removal causes swelling, trismus, and moderate to severe pain which can be treated with various NSAID’s drugs, which have numerous side effects and gastric disturbances. In order to bypass such disturbances, Tramadol may be considered as an alternative for such patients. The aim of the study was to evaluate analgesic efficacy of submucosal tramadol and its implication over swelling and mouth opening after mandibular third molar surgery.Methods: This is a prospective study where in after post-surgical extraction of mandibular third molar, efficacy of submucosal injection of tramadol is evaluated in terms of pain and its implication over swelling and mouth opening.Results: The present study suggested there was statistically significant VAS score for pain after submucosally injecting tramadol post-surgical extraction of mandibular third molar in the following visits- 4hourly, 8hourly and 24hourly. In respect to swelling, statistically significant values was noted during 24hr and 72 h our post extraction. Also in case of mouth opening, statistically significant values were found 24 hourly.Conclusions: The present pilot study concluded that submucosal tramadol post mandibular third molar extraction has been effective in reducing pain, limiting post-extraction swelling and less impacting mouth opening by inducing less complications thereby bypassing gastric disturbances.

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