Alterations in stress-induced prolactin release in adult female and male rats exposed to stress, in utero

ABSTRACT Relationships among the release of prolactin, the effect of oestrogens and the proliferation of prolactin-secreting cells were studied under several experimental conditions. Administration of sulpiride or oestradiol released prolactin and stimulated cell proliferation in the anterior pituitary gland of adult male rats. Clomiphene completely abolished the rise in cell proliferation, but did not interfere with the sulpiride-induced release of prolactin. Treatment with oestradiol plus sulpiride significantly increased serum prolactin concentrations and the mitotic index compared with the sum of the stimulation produced by both drugs separately. Bromocriptine abolished the stimulatory effect of oestradiol on the serum prolactin concentration and on cell proliferation. In oestradiol- and/or sulpiride-treated rats, 80% of the cells in mitoses were lactotrophs. The remaining 20% did not stain with antisera against any of the pituitary hormones. The number of prolactin-secreting cells in the anterior pituitary gland significantly increased after the administration of oestradiol or sulpiride. The results demonstrate that treatment with sulpiride and/or oestradiol increases the proliferation and the number of lactotrophs in the anterior pituitary gland of the rat. J. Endocr. (1986) 108, 399–403

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Birthweight Depression in Male Rats Contiguous to Male Siblings in Utero Exposed to High Doses of 1,3-Butanediol during Organogenesis

Journal of the American College of Toxicology ◽

10.3109/10915818609140743 ◽

1986 ◽

Vol 5 (4) ◽

pp. 189-196 ◽

Cited By ~ 3

Author(s):

R. F. Mankes ◽

V. Renak ◽

J. Fieseher ◽

R. Lefevre

Keyword(s):

Developmental Toxicity ◽

In Utero ◽

Cellular Damage ◽

Male Rats ◽

Body Weights ◽

Fetal Repair ◽

Dose Dependent Decrease ◽

High Doses ◽

Embryotoxic Effects ◽

Dose Dependent

The embryotoxic effects of high doses of the narcotizing ethanol dimer 1,3-butanediol were evaluated in pregnant Long-Evans rats during the “critical period” of organogenesis. Butanediol was given by gavage at levels of 0,7060,4236, or 706 mg/kg per day (24,14.4, or 2.4% of the acute oral LD50 value for rats). Maternal sedation was observed at 7060 and 4236 mg/kg, but feed consumptions and maternal body weights were unaffected. Butanediol caused a significant, dose-dependent decrease in offspring birthweights. At the highest butanediol dose, birthweights were preferentially and significantly decreased in male pups not contiguous in utero to female siblings. Other group I1 offspring were not affected and did not differ significantly from controls. As butanediol was given prior to the period of greatest fetal growth and fetal sex steroidogenests, it is concluded that intra-uterine levels of female sex steroids (estradiol) enhance fetal repair of cellular damage (restitution ad integrum), whereas testosterone inhibits fetal repair or exacerbates previous embryonic damage by some unknown mechanism. Such interaction furthers the concept that intrauterine position affects the endpoints of developmental toxicity, as expressed at partuition.

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Prenatal morphine exposure alters estrogen regulation of κ receptors in the cortex and POA of adult female rats but has no effects on these receptors in adult male rats

Brain Research ◽

10.1016/s0006-8993(00)03326-6 ◽

2001 ◽

Vol 894 (1) ◽

pp. 154-156 ◽

Cited By ~ 22

Author(s):

Ágnes Rimanóczy ◽

Romana Šlamberová ◽

Ilona Vathy

Keyword(s):

Adult Female ◽

Adult Male ◽

Female Rats ◽

Male Rats ◽

Estrogen Regulation

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Kisspeptin Stimulation of Prolactin Secretion Requires Kiss1 Receptor but Not in Tuberoinfundibular Dopaminergic Neurons

Endocrinology ◽

10.1210/en.2018-00932 ◽

2019 ◽

Vol 160 (3) ◽

pp. 522-533 ◽

Cited By ~ 5

Author(s):

Nayara S S Aquino ◽

Ilona C Kokay ◽

Carolina Thörn Perez ◽

Sharon R Ladyman ◽

Patricia C Henriques ◽

...

Keyword(s):

Dopaminergic Neurons ◽

Prolactin Secretion ◽

Female Rats ◽

Male Rats ◽

Prolactin Release ◽

Whole Cell Patch Clamp ◽

Neuropeptide Ff ◽

Concomitant Reduction ◽

Prolactin Response

Abstract Kisspeptin has been shown to stimulate prolactin secretion. We investigated whether kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin. Initially, we evaluated prolactin response in a Kiss1r-deficient mouse line, in which Kiss1r had been knocked into GnRH neurons (Kiss1r−/−R). Intracerebroventricular kisspeptin-10 (Kp-10) increased prolactin release in wild-type but not in Kiss1r−/−R female mice. In ovariectomized, estradiol-treated rats, the Kiss1r antagonist kisspeptin-234 abolished the Kp-10–induced increase in prolactin release but failed to prevent the concomitant reduction in the activity of tuberoinfundibular dopaminergic (TIDA) neurons, as determined by the 3,4-dihydroxyphenylacetic acid/dopamine ratio in the median eminence. Using whole-cell patch clamp recordings in juvenile male rats, we found no direct effect of Kp-10 on the electrical activity of TIDA neurons. In addition, dual-label in situ hybridization in the hypothalamus of female rats showed that Kiss1r is expressed in the periventricular nucleus of the hypothalamus (Pe) and arcuate nucleus of the hypothalamus (ARC) but not in tyrosine hydroxylase (Th)–expressing neurons. Kisspeptin also has affinity for the neuropeptide FF receptor 1 (Npffr1), which was expressed in the majority of Pe dopaminergic neurons but only in a low proportion of TIDA neurons in the ARC. Our findings demonstrate that Kiss1r is necessary to the effect of kisspeptin on prolactin secretion, although TIDA neurons lack Kiss1r and are electrically unresponsive to kisspeptin. Thus, kisspeptin is likely to stimulate prolactin secretion via Kiss1r in nondopaminergic neurons, whereas the colocalization of Npffr1 and Th suggests that Pe dopaminergic neurons may play a role in the kisspeptin-induced inhibition of dopamine release.

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Effects of the two partial D2 agonists (+)- and (−)-3-PPP on prolactin release in EEDQ treated male rats

Life Sciences ◽

10.1016/0024-3205(91)90551-l ◽

1991 ◽

Vol 48 (4) ◽

pp. 311-320 ◽

Cited By ~ 5

Author(s):

Agneta Ekman ◽

Marianne Quiding ◽

Elias Eriksson

Keyword(s):

Male Rats ◽

Prolactin Release ◽

Treated Male

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