Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds

1996 ◽  
Vol 41 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Bing Hui Wang ◽  
Gideon M. Polya
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Selective Inhibition ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Related Compounds

scholarly journals Beryllium toxicity. The selective inhibition of casein kinase 1

1982 ◽  
Vol 208 (1) ◽  
pp. 141-146 ◽  
Author(s):  
B Cummings ◽  
M R Kaser ◽  
G Wiggins ◽  
M G Ord ◽  
L A Stocken
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Selective Inhibition ◽  
Casein Kinase ◽  
Dependent Protein Kinase ◽  
Casein Kinase 1 ◽  
Protein Substrate ◽  
Dependent Protein ◽  
Intact Rats

1. Cyclic AMP-independent casein kinase 1 in liver cytoplasm and nuclei was inhibited by Be2+ in vitro (Ki 2.5 microM and 29 microM respectively). Casein kinase 2 (phosvitin kinase) and cyclic AMP-dependent protein kinase were unaffected. 2. The inhibition of casein kinase 1 by Be2+ was competitive with respect to the protein substrate; at non-saturating concentrations of casein, inhibition was non-competitive with respect to ATP. 3. In rats given LD50 doses of Be2+ 24 h before death, the activities of cytoplasmic and nuclear casein kinase 1 in livers from partially hepatectomized animals were diminished approx. 50%; with intact rats, nuclear casein kinase 1 was inhibited at concentrations of casein less than the Km.

Selective Inhibition of Cyclic AMP-Dependent Protein Kinase by Isoquinoline Derivatives

1996 ◽  
Vol 377 (6) ◽  
pp. 373-384 ◽  
Author(s):  
Lu Zhe Xiong ◽  
Quazi Nurul Huda ◽  
Deady Leslie W. ◽  
Polya Gideon M.
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Selective Inhibition ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Isoquinoline Derivatives

scholarly journals A cytosolic cyclic AMP-dependent protein kinase in Dictyostelium discoideum. I. Properties.

1984 ◽  
Vol 259 (1) ◽  
pp. 654-661 ◽  
Author(s):  
I H Majerfeld ◽  
B H Leichtling ◽  
J A Meligeni ◽  
E Spitz ◽  
H V Rickenberg
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Dictyostelium Discoideum ◽  
Dependent Protein Kinase ◽  
Dependent Protein
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