Beryllium toxicity. The selective inhibition of casein kinase 1
Keyword(s):
1. Cyclic AMP-independent casein kinase 1 in liver cytoplasm and nuclei was inhibited by Be2+ in vitro (Ki 2.5 microM and 29 microM respectively). Casein kinase 2 (phosvitin kinase) and cyclic AMP-dependent protein kinase were unaffected. 2. The inhibition of casein kinase 1 by Be2+ was competitive with respect to the protein substrate; at non-saturating concentrations of casein, inhibition was non-competitive with respect to ATP. 3. In rats given LD50 doses of Be2+ 24 h before death, the activities of cytoplasmic and nuclear casein kinase 1 in livers from partially hepatectomized animals were diminished approx. 50%; with intact rats, nuclear casein kinase 1 was inhibited at concentrations of casein less than the Km.
1984 ◽
Vol 259
(20)
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pp. 12857-12864
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1993 ◽
Vol 268
(27)
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pp. 20076-20084
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1992 ◽
Vol 12
(4)
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pp. 1507-1514
2004 ◽
Vol 99
(8)
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pp. 845-854
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Keyword(s):
1992 ◽
Vol 12
(10)
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pp. 4478-4485
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1987 ◽
Vol 7
(4)
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pp. 1371-1377
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1992 ◽
Vol 12
(10)
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pp. 4478-4485
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