Muscle dedifferentiation and contractile protein synthesis during post-traumatic regeneration by Owenia fusiformis (polychaete annelid)

1983 ◽  
Vol 13 (4) ◽  
pp. 267-282 ◽  
Author(s):  
Michel Fontés ◽  
Josiane Coulon ◽  
Marie-Hélène Delgross ◽  
Yves Thouveny
1991 ◽  
Vol 130 (2) ◽  
pp. 239-244 ◽  
Author(s):  
N. K. Green ◽  
M. D. Gammage ◽  
J. A. Franklyn ◽  
M. C. Sheppard

ABSTRACT Effects of thyroid status on expression of a variety of myocardial genes, such as those encoding contractile proteins, have been reported, as well as interactions between thyroid hormones and developmental and haemodynamic regulation of contractile protein synthesis. In addition, it is clear that developmental and haemodynamic factors regulate expression of specific proto-oncogenes, including c-myc, c-fos and H-ras, in the myocardium but the effect of thyroid status on such proto-oncogene products, which are proposed to play a critical signal-transducing role in the heart, has been previously unexplored. In order to determine whether changes in thyroid status are associated with changes in expression of these putative intracellular signals, we examined the effect of hypothyroidism and tri-iodothyronine (T3) treatment on myocardial levels of c-myc, c-fos and H-ras mRNAs in the rat. The induction of hypothyroidism was associated with a marked increase in myocardial c-myc, c-fos and H-ras mRNAs, changes reversed by 72 h of T3 replacement. Administration of T3 to euthyroid rats had no significant effect on myocardial c-myc or c-fos mRNAs, but inhibition of H-ras mRNA by T3 was evident. These observations demonstrating influences of thyroid status on expression of specific proto-oncogenes suggest that thyroid hormones, as well as exerting direct effects on expression of functionally important myocardial genes, also interact with the cellular transduction pathways mediated by the products of the c-myc, c-fos and H-ras genes. Journal of Endocrinology (1991) 130, 239–244


2021 ◽  
Author(s):  
William J. Evans ◽  
Mahalakshmi Shankaran ◽  
Edward C. Smith ◽  
Carl Morris ◽  
Edna Nyangau ◽  
...  

2011 ◽  
Vol 83 (4) ◽  
pp. 1363-1372 ◽  
Author(s):  
Natália G. Fiorenza ◽  
Dagieli Sartor ◽  
Jociane C. Myskiw ◽  
Iván Izquierdo

Retrieval labilizes memory traces and these gates two protein synthesis-dependent processes in the brain: extinction, which inhibits further retrieval, and reconsolidation, which may enhance retrieval or change its content. Extinction may itself suffer reconsolidation. Interactions among these processes may be applied to treatments of fear memories, such as those underlying post-traumatic stress disorders.


1986 ◽  
Vol 18 ◽  
pp. 66-66
Author(s):  
S SCHREIBER ◽  
F REFF ◽  
C EVANS ◽  
M ORATZ ◽  
M ROTHSCHILD

1997 ◽  
Vol 2 (1) ◽  
pp. 67-79 ◽  
Author(s):  
JASPAUL S. MARWAY ◽  
JOHN P. MIELL ◽  
JENNY JONES ◽  
ADRIAN B. BONNER ◽  
MICHAEL A. PREECE ◽  
...  

1994 ◽  
Vol 22 (2) ◽  
pp. 194S-194S ◽  
Author(s):  
JASPAUL S. MARWAY ◽  
TAHIR SIDDIQ ◽  
PAUL GIBBS ◽  
PAUL EDWARDS ◽  
VICTOR R. PREEDY

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