scholarly journals Treatment of fear memories: interactions between extinction and reconsolidation

2011 ◽  
Vol 83 (4) ◽  
pp. 1363-1372 ◽  
Author(s):  
Natália G. Fiorenza ◽  
Dagieli Sartor ◽  
Jociane C. Myskiw ◽  
Iván Izquierdo
Keyword(s):  
Protein Synthesis ◽  
Traumatic Stress ◽  
Stress Disorders ◽  
Post Traumatic Stress ◽  
Memory Traces ◽  
Traumatic Stress Disorders ◽  
Post Traumatic ◽  
The Brain ◽  
Dependent Processes

Retrieval labilizes memory traces and these gates two protein synthesis-dependent processes in the brain: extinction, which inhibits further retrieval, and reconsolidation, which may enhance retrieval or change its content. Extinction may itself suffer reconsolidation. Interactions among these processes may be applied to treatments of fear memories, such as those underlying post-traumatic stress disorders.

scholarly journals PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory

2021 ◽  
Author(s):  
C. Bouarab ◽  
V. Roullot-Lacarrière ◽  
M. Vallée ◽  
A. Le Roux ◽  
C. Guette ◽  
...  
Keyword(s):  
Traumatic Stress ◽  
Predictive Biomarker ◽  
Stress Disorders ◽  
Glucocorticoid Hormones ◽  
Post Traumatic Stress ◽  
Traumatic Stress Disorders ◽  
Post Traumatic ◽  
Very High ◽  
Moderate Stress ◽  
Pai 1

AbstractModerate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.

Sign in / Sign up

Export Citation Format

Share Document