Surfactant-associated glycoproteins accumulate in alveolar cells and secretions during reparative stage of hyaline membrane disease

The alveoli of the normal lung are lined by a substance which exerts surface tension at the air-liquid interface. In the expanded lung the tension is high and operates to increase the elastic recoil of the lung. In the lung at low volumes the surface tension becomes extremely low. This confers stability on the airspaces and thus prevents atelectasis. This lining layer is a lipoprotein film, which is not found where alveoli are still lined by cuboidal epithelium. Its time of appearance coincides with the appearance of alveolar lining cells. Electron microscopic evidence of secretory activity in alveolar cells suggests that they may be the source of the surface-active film. The normal alveolar lining layer is not present in lungs of infants who die from profound atelectasis and hyaline membrane disease. Whether its absence is a failure of development or due to inactivation is not established.

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ADRENAL GLAND STRUCTURE AND THE DEVELOPMENT OF HYALINE MEMBRANE DISEASE

PEDIATRICS ◽

10.1542/peds.47.4.650 ◽

1971 ◽

Vol 47 (4) ◽

pp. 650-657

Author(s):

Richard L. Naeye ◽

Howard T. Harcke ◽

William A. Blanc

Keyword(s):

Adrenal Glands ◽

Hyaline Membrane Disease ◽

Alveolar Cells ◽

Cortical Function ◽

Lung Maturation ◽

Cortical Cells ◽

Corticosteroid Administration ◽

Osmiophilic Granules ◽

Hyaline Membrane ◽

Type Ii Alveolar Cells

Adrenal cortical function may influence the development of hyaline membrane disease. Corticosteroid administration to animal fetuses reportedly accelerates some parameters of lung maturation. Analysis of 387 consecutive autopsies on human neonates demonstrated that adrenal glands were 19% lighter in infants with hyaline membrane disease than in those without the disorder owing to a greater number of adrenal cortical cells in the latter infants. A positive correlation was found between the presence of infection arising before birth and the absence of hyaline membrane disease, the infected infants having larger adrenal glands. It was found that anencephalic neonates who had little or no adrenal fetal cortical zone and half sized adult zones had 45% the mass of osmiophilic granules in pulmonary type II alveolar cells as did nonanencephalic control infants. The osmiophilic granules are reportedly the anatomic representation of surfactant.

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TYPE OF ANÆSTHESIA AND HYALINE MEMBRANE DISEASE

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1967.tb21625.x ◽

1967 ◽

Vol 1 (15) ◽

pp. 790-790

Keyword(s):

Hyaline Membrane Disease ◽

Hyaline Membrane ◽

Type Of Anaesthesia

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Relationship Between Incidence of Hyaline Membrane Disease and Maternal Hypertension During Pregnancy

Paediatrica Indonesiana ◽

10.14238/pi38.3-4.1998.47-53 ◽

2017 ◽

Vol 38 (3-4) ◽

pp. 47

Author(s):

Lasmida Nazir Nuriman ◽

Dadang Sjarif Hidajat

Keyword(s):

Distress Syndrome ◽

Hyaline Membrane Disease ◽

Cross Sectional Study ◽

Type I ◽

Cross Sectional ◽

Hypertension In Pregnancy ◽

Hyaline Membrane ◽

Neonatal Respiratory Distress ◽

Maternal Hypertension ◽

The Relationship

There have been controversies over the eiTect of hypertension in pregnancy on the incidence of type I neonatal respiratory distress syndrome or hyaline membrane disease (HMD). We investigated the relationship between the incidence of HMD and maternal hypertension during pregnancy in 91 infants at 34 weeks gestation or less. This retrospective cross sectional study included all live born babies between May 1, 1994 and April 30, 1995 at Dr. Hasan Sadikin General Hospital, Bandung. Maternal hypertension during pregnancy was diagnosed in 38 mothers of91 infants studied. The incidence of HMD (5%) in the maternal hypertension during pregnancy group was significantly lower than the 62% in the normotensive group (p<0.01). There was a negative correlation between the occurence of HMD and hypertension during pregnancy. We conclude that the risk of developing HMD in infants born to hypertensive mothers is significantly lower than those born to normotensive mothers.

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