Lack of isotype exclusion and expression of aberrant lambda light chain on secreted MOPC-315 myeloma proteins

1986 ◽  
Vol 23 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Ju Shyr-Te ◽  
David Pinto ◽  
Martin E. Dorf
Keyword(s):  
Light Chain ◽  
Lambda Light Chain ◽  
Myeloma Proteins

scholarly journals Untranslated immunoglobulin kappa light chain mRNA in a lambda light chain-producing mouse myeloma, MOPC104E.

1980 ◽  
Vol 255 (11) ◽  
pp. 5291-5295
Author(s):  
T. Kataoka ◽  
M. Ono ◽  
M. Kawakami ◽  
Y. Ikawa ◽  
M. Aida ◽  
...  
Keyword(s):  
Light Chain ◽  
Kappa Light Chain ◽  
Lambda Light Chain ◽  
Immunoglobulin Kappa ◽  
Mouse Myeloma

scholarly journals Immunohistochemical Characterization of Canine Transmissible Venereal Tumor

1996 ◽  
Vol 33 (3) ◽  
pp. 257-263 ◽  
Author(s):  
E. Mozos ◽  
A. Méndez ◽  
J. C. Gómez-Villamandos ◽  
J. Martín de las Mulas ◽  
J. Pérez
Keyword(s):  
Light Chain ◽  
B Lymphocyte ◽  
Protein S ◽  
Lambda Light Chain ◽  
Formalin Fixed Paraffin ◽  
S 100 ◽  
Formalin Fixed Paraffin Embedded ◽  
Progressive Growth ◽  
Staining Techniques ◽  
Alpha 1 Antitrypsin

The collective immunohistochemical expression of human lysozyme, human alpha-1-antitrypsin, human CD3 antigen, calf vimentin, human keratins, human lambda light chains, canine immunoglobulins IgG, IgM, and bovine protein S-100 has been analyzed on formalin-fixed, paraffin-embedded tissue sections of 25 spontaneous canine transmissible venereal tumors (CTVT) from both genital and extragenital locations using the avidin-biotin-peroxidase complex technique. Lysozyme immunoreactivity was detected in 10/25 CTVT, alpha-1-antitrypsin in 14/25 CTVT, and vimentin in 25/25 CTVT. All CTVT cells were negative to keratins 5 + 8 of the Moll catalogue (RCK-102), S-100 protein, lambda light-chain immunoglobulins, IgG, IgM, and CD3 antigen. The intratumoral T- and B-lymphocyte infiltrate was differentiated using CD3 antigen, lambda light-chain immunoglobulins, IgG, and IgM, and this technique could be useful to evaluate the regressive or progressive growth stage of venereal tumors. Our findings support the hypothesis of a histiocytic immunophenotype for CTVT, and these staining techniques could be used in the differential diagnosis with lymphomas.

Sequence Communication AL 612, a glycosylated lambda light chain of subgroup I

Amyloid ◽  
2000 ◽  
Vol 7 (1) ◽  
pp. 51-53
Author(s):  
Trine Nilsen ◽  
Knut Sletten ◽  
Per Westermark
Keyword(s):  
Light Chain ◽  
Lambda Light Chain

Lambda-Light-Chain-Mediated Anti-GBM Disease

Nephron ◽  
1989 ◽  
Vol 52 (2) ◽  
pp. 144-148 ◽  
Author(s):  
J.A. Savige ◽  
S.P. Yeung ◽  
A.R. Bierre ◽  
Priscilla Kincaid-Smith
Keyword(s):  
Light Chain ◽  
Lambda Light Chain

scholarly journals Systemic lambda light-chain deposition in a patient with myeloma.

BMJ ◽  
1981 ◽  
Vol 282 (6265) ◽  
pp. 681-683 ◽  
Author(s):  
D Ganeval ◽  
L H Noel ◽  
D Droz ◽  
J Leibowitch
Keyword(s):  
Light Chain ◽  
Lambda Light Chain ◽  
Light Chain Deposition

scholarly journals Rearranged antigen receptor genes in Hodgkin's disease [published erratum appears in Blood 1987 Sep;70(3):893]

Blood ◽  
1987 ◽  
Vol 70 (1) ◽  
pp. 96-103 ◽  
Author(s):  
J Sundeen ◽  
E Lipford ◽  
M Uppenkamp ◽  
E Sussman ◽  
L Wahl ◽  
...  
Keyword(s):  
T Cell ◽  
Light Chain ◽  
Hodgkin's Disease ◽  
Cell Separation ◽  
Gene Rearrangement ◽  
Hodgkin’S Disease ◽  
Antigen Receptor ◽  
Lambda Light Chain ◽  
Separation Techniques ◽  
Abnormal Cells

Abstract Despite intensive efforts using a wide variety of approaches, the cellular lineage and clonality of the abnormal cells of Hodgkin's disease have remained an enigma. In the present study, cell separation techniques that enriched for Reed-Sternberg cells and their variants were used to generate sufficient percentages of abnormal cells to allow detection of rearrangements in these cell fractions. DNA from the involved tissues of eight Hodgkin's disease patients was subjected to Southern blot analysis to detect rearrangements of T cell antigen receptor genes and immunoglobulin genes. Immunoglobulin gene rearrangements were found in three of five cases in which Reed- Sternberg cells and their variants were enriched by cell separation techniques to cell frequencies greater than 1%. Rearrangements of immunoglobulin heavy chain genes occurred in two cases, and a lambda light chain gene rearrangement occurred in a third case. Rearrangements were not detected in lymphocyte fractions or in unseparated cells prepared from the same tissues. The putative Hodgkin's cell line, L428, also contained rearrangements of immunoglobulin heavy and kappa and lambda light chain genes and, in addition, harbored a single T cell receptor beta gene rearrangement. These findings indicate that Reed- Sternberg cell-enriched fractions contain clonal cell populations and provide a lead, at the molecular genetic level, to a possible lymphoid derivation of the Reed-Sternberg cell.

Immunoglobulin light-chain genes in the rhesus macaque II: lambda light-chain germline sequences for subgroups IGLV1, IGLV2, IGLV3, IGLV4 and IGLV5

2005 ◽  
Vol 57 (9) ◽  
pp. 655-664 ◽  
Author(s):  
Wendy A. Howard ◽  
Jon M. Bible ◽  
Eva Finlay-Dijsselbloem ◽  
Sam Openshaw ◽  
Deborah K. Dunn-Walters
Keyword(s):  
Rhesus Macaque ◽  
Light Chain ◽  
Immunoglobulin Light Chain ◽  
Lambda Light Chain
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