Probability density of ultrasonic backscatter from tissue-equivalent phantom, in-vivo canine myocardium and in-vivo human myocardium J.B. Hampshire II, J.W. Strohbehn, M.D. McDaniel, P.J. Fitzgerald, J.A. Power and D.H. James, Thayer School of Engineering, Dartmouth College and Dartmouth-Hitchcock Medical Center, Hanover, NH 03756

Objective.The presence of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) indicates a breach in immune tolerance. Recent studies indicate that this breach extends to homocitrullination of lysines with the formation of anti-carbamylated protein (anti-CarP) antibodies. We analyzed the clinical and serologic relationships of anti-CarP in 2 RA cohorts.Methods.Circulating levels of immunoglobulin G anti-CarP antibodies were determined by ELISA in established (Dartmouth-Hitchcock Medical Center) and early (Sherbrooke University Hospital Center) cohorts and evaluated for anticyclic citrullinated peptide antibodies (anti-CCP), specific ACPA, and rheumatoid factor (RF) levels using the Student t test and correlation analysis.Results.We identified elevated anti-CarP antibodies titers in 47.0% of seropositive patients (Dartmouth, n = 164), with relationships to anti-CCP (p < 0.0001) and IgM-RF (p = 0.001). Similarly, 38.2% of seropositive patients from the Sherbrooke cohort (n = 171) had elevated anti-CarP antibodies; titers correlated to anti-CCP (p = 0.01) but not IgM-RF (p = 0.09). A strong correlation with anti-Sa was observed: 47.9% anti-Sa+ patients were anti-CarP antibodies+ versus only 25.4% anti-Sa− in the Sherbrooke cohort (p = 0.0002), and 62.6% anti-Sa+ patients versus 26.9% anti-Sa− were anti-CarP antibodies+ in Dartmouth (p < 0.0001). We found a more variable response for reactivity to citrullinated fibrinogen or to citrullinated peptides from fibrinogen and α enolase.Conclusion.In 2 North American RA cohorts, we observed a high prevalence of anti-CarP antibody positivity. We also describe a surprising and unexpected association of anti-CarP with anti-Sa antibodies that could not be explained by cross-reactivity. Further, considerable heterogeneity exists between anti-CarP reactivity and other citrullinated peptide reactivity, raising the question of how the pathogenesis of antibody responses for carbamylated proteins and citrullinated proteins may be linked in vivo.

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Anisotropy of ultrasonic backscatter in canine myocardium: Results in vivo Eric I. Madaras, Julio E. Perez, Burton E. Sobel, and J.G. Miller, Department of Physics and Division of Cardiology, Washington University, St. Louis, MO 63130

Ultrasonic Imaging ◽

10.1016/0161-7346(86)90023-4 ◽

1986 ◽

Vol 8 (1) ◽

pp. 35-36 ◽

Cited By ~ 5

Keyword(s):

Ultrasonic Backscatter ◽

Washington University ◽

Canine Myocardium

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Ultrasonic texture analysis to discriminate between normal, ischemic and infarcted myocardium Peter J. Fitzgerald, Jon A. Magnuson, Douglas H. James and John W. Strohbehn, Dartmouth-Hitchcock Medical Center and Thayer School of Engineering, Hanover, NH 03756

Ultrasonic Imaging ◽

10.1016/0161-7346(87)90030-7 ◽

1987 ◽

Vol 9 (1) ◽

pp. 52

Keyword(s):

Texture Analysis ◽

Medical Center ◽

Infarcted Myocardium ◽

Thayer School ◽

Dartmouth Hitchcock Medical

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The Production and Evaluation of the Tissue-equivalent Phantom for the Magnetic Resonance Imaging

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1994.30.6.1151 ◽

1994 ◽

Vol 30 (6) ◽

pp. 1151

Author(s):

Young Hoon Ryu ◽

Jae Hyun Cho ◽

Jin Suck Suh ◽

Jae Myun Lee ◽

Eun Kee Jeong

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Tissue Equivalent ◽

Tissue Equivalent Phantom

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Influence of Different Percentages of Binders on the Physico-Mechanical Properties of Rhizophora spp. Particleboard as Natural-Based Tissue-Equivalent Phantom for Radiation Dosimetry Applications

Polymers ◽

10.3390/polym13111868 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1868

Author(s):

Siti Hajar Zuber ◽

Nurul Ab. Aziz Hashikin ◽

Mohd Fahmi Mohd Yusof ◽

Mohd Zahri Abdul Aziz ◽

Rokiah Hashim

Keyword(s):

Mechanical Properties ◽

Radiation Dosimetry ◽

Structural Integrity ◽

Soy Flour ◽

Lower Percentage ◽

Internal Bonding ◽

X Ray ◽

Tissue Equivalent ◽

Tissue Equivalent Phantom ◽

Edx Analyses

Rhizophora spp. particleboard with the incorporation of lignin and soy flour as binders were fabricated and the influence of different percentages of lignin and soy flour (0%, 6% and 12%) on the physico-mechanical properties of the particleboard were studied. The samples were characterised by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray fluorescence (XRF) and internal bonding. The results stipulated that the addition of binders in the fabrication of the particleboard did not change the functional groups according to the FTIR spectrum. For XRD, addition of binders did not reveal any major transformation within the composites. SEM and EDX analyses for all percentages of binders added showed no apparent disparity; however, it is important to note that the incorporation of binders allows better bonding between the molecules. In XRF analysis, lower percentage of chlorine in the adhesive-bonded samples may be advantageous in maintaining the natural properties of the particleboard. In internal bonding, increased internal bond strength in samples with binders may indicate better structural integrity and physico-mechanical strength. In conclusion, the incorporation of lignin and soy flour as binders may potentially strengthen and fortify the particleboard, thus, can be a reliable phantom in radiation dosimetry applications.

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