Efficacy of (E)-5-(2-bromovinyl)-2′-deoxyuridine against different herpes simplex virus strains in cell culture and against experimental herpes encephalitis in mice

1982 ◽  
Vol 2 (5) ◽  
pp. 255-265 ◽  
Author(s):  
J. Reefschläger ◽  
P. Wutzler ◽  
K.-D. Thiel ◽  
D. Bärwolff ◽  
P. Langen ◽  
...  
Keyword(s):  
Cell Culture ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Encephalitis ◽  
Simplex Virus ◽  
Virus Strains

scholarly journals Neonatal Herpes Encephalitis Caused by a Virologically Confirmed Acyclovir-Resistant Herpes Simplex Virus 1 Strain

2012 ◽  
Vol 51 (1) ◽  
pp. 356-359 ◽  
Author(s):  
Satsuki Kakiuchi ◽  
Shigeaki Nonoyama ◽  
Hajime Wakamatsu ◽  
Kazuhiro Kogawa ◽  
Lixin Wang ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Encephalitis ◽  
Neonatal Herpes ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

scholarly journals Activity of Penciclovir in Combination with Azido-Thymidine, Ganciclovir, Acyclovir, Foscarnet and Human Interferons against Herpes Simplex Virus Replication in Cell Culture

1992 ◽  
Vol 3 (2) ◽  
pp. 85-94 ◽  
Author(s):  
D. Sutton ◽  
J. Taylor ◽  
T. H. Bacon ◽  
M. R. Boyd
Keyword(s):  
Cell Culture ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Antiviral Agents ◽  
High Concentrations ◽  
Simplex Virus ◽  
Hsv 1

Combinations of penciclovir (PCV) with other antiviral agents (acyclovir, ACV; ganciclovir, GCV; foscarnet, PFA; azido-thymidine, AZT) or with human interferons (HulFN-α,β,γ) were tested for inhibitory activity against herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) in cell culture. The antiviral interactions observed between combinations of PCV with ACV or GCV were purely additive. Combinations of PCV with HulFNs demonstrated highly synergistic anti-herpesvirus activity; some synergy was also detected between PCV and PFA against HSV-1. High concentrations of AZT inhibited the antiviral activity of PCV; this antagonism was competitive. In more detailed studies it was demonstrated that high concentrations of AZT also inhibited the antiviral activity of ACV, and that ACV was more sensitive to this antagonism than PCV. It was concluded that the antagonism was unlikely to have clinical significance.

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