Food restriction in female Wistar rats. VII. Mitochondrial parameters in resting and proliferating splenic lymphocytes

1994 ◽  
Vol 19 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Carlo Pieri ◽  
Rina Recchioni ◽  
Fausto Moroni ◽  
Fiorella Marcheselli ◽  
Maurizio Marra
Keyword(s):  
Food Restriction ◽  
Wistar Rats ◽  
Splenic Lymphocytes ◽  
Female Wistar Rats

Food restriction in female Wistar rats. II. β-adrenoceptor density in the cerebellum and in the splenic lymphocytes

1990 ◽  
Vol 11 (2) ◽  
pp. 109-115 ◽  
Author(s):  
C. Pieri ◽  
F. Moroni ◽  
F. Marcheselli ◽  
M. Falasca ◽  
R. Recchioni
Keyword(s):  
Food Restriction ◽  
Wistar Rats ◽  
Splenic Lymphocytes ◽  
Female Wistar Rats

scholarly journals The influence of food restriction versus ad libitum feeding of chow and purified diets on variation in body weight, growth and physiology of female Wistar rats

2012 ◽  
Vol 46 (2) ◽  
pp. 101-107 ◽  
Author(s):  
M Moraal ◽  
P P A M Leenaars ◽  
H Arnts ◽  
K Smeets ◽  
B S Savenije ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Restriction ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Blood Parameters ◽  
Calorie Intake ◽  
Restricted Feeding ◽  
Organ Weights ◽  
Female Wistar Rats ◽  
Ad Libitum

Ad libitum (AL) supply of standard chow is the feeding method most often used for rodents in animal experiments. However, AL feeding is known to result in a shorter lifespan and decreased health as compared with restricted feeding. Restricted feeding and thus limiting calorie intake prevents many health problems, increases lifespan and can also increase group uniformity. All this leads to a reduced number of animals needed. So-called standard chows are known to be prone to variation in composition. Synthetic foods have a more standard composition, contributing to group uniformity which, like diet reduction, may decrease the number of animals necessary to obtain statistical significance. In this study, we compared the effects of AL versus restricted feeding (25% reduction in food intake) on standard chow versus synthetic food of three different suppliers on body weight (BW), growth, several blood parameters and organ weights in growing female Wistar rats over a period of 61 days. Diet restriction led to a decreased growth and significantly reduced variation in BW and growth as compared with AL feeding. AL feeding on synthetic diets caused a significantly higher BW gain than on chow diets. Due to experimental design, this same effect occurred on food restriction. Blood parameters and organ weights were affected neither by diet type nor by amount. Incidentally, variations were significantly reduced on food restriction versus AL, and on synthetic diets versus chow diets. This study demonstrates that food restriction versus AL feeding leads to a significantly reduced variation in BW and growth, thereby indicating the potential for reduction when applying this feeding schedule.

Serum leptin is not correlated with body fat in severe food restriction

2012 ◽  
Vol 37 (6) ◽  
pp. 1063-1071 ◽  
Author(s):  
Sarah E. Gairdner ◽  
Catherine E. Amara
Keyword(s):  
Body Composition ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Food Restriction ◽  
Wistar Rats ◽  
Serum Leptin ◽  
Wide Range ◽  
Female Wistar Rats ◽  
Ad Libitum

Leptin is an adipose-derived hormone with established roles in energy balance that can impact the response to refeeding after malnutrition. Although the amount of circulating leptin has traditionally been associated with the amount of adipose tissue, controversy exists as to whether this relationship is constant in both humans and animals and over a wide range of body composition. Our objective was to evaluate whether the leptin – body fat ratio is constant in the range of healthy to low body mass in female Wistar rats. Eight ad libitum fed (C) and eight food-restricted (FR) rats were compared over a period of four weeks. FR rats attained the target 75% of baseline body mass after the first two weeks, which was maintained for the remaining two weeks. Serum leptin and IGF-1 (ELISA) and body composition (DXA) were measured at baseline (t0) and once weekly for the remainder of the study (t1–t4). The leptin – body fat ratio was reduced during the two-week period of weight loss (t0 = 0.036 ± 0.016 (ng·mL–1)·g–1 vs. t1 = 0.010 ± 0.004 (ng·mL–1)·g–1 and t2 = 0.015 ± 0.007 (ng·mL–1)·g–1, p < 0.05). Leptin concentration plateaued at its nadir (~0.24 (ng·mL–1)·g–1) at fat mass < 22 g. IGF-1 was correlated with lean mass (r = 0.45, p < 0.05) and fat mass (r = 0.58, p < 0.05), regardless of body mass. We concluded that the leptin – body fat ratio was reduced early in food restriction and the correlation between these two variables was absent at low body fat.

Food restriction in female Wistar rats: V. Lipid peroxidation and antioxidant enzymes in the liver

1992 ◽  
Vol 14 (1) ◽  
pp. 93-99 ◽  
Author(s):  
C. Pieri ◽  
M. Falasca ◽  
F. Marcheselli ◽  
F. Moroni ◽  
R. Recchioni ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Food Restriction ◽  
Wistar Rats ◽  
Female Wistar Rats

Food restriction in female Wistar rats, IV. Morphometric parameters of cerebellar synapses

1991 ◽  
Vol 13 (2) ◽  
pp. 161-165
Author(s):  
C. Pieri ◽  
F. Marcheselli ◽  
M. Falasca ◽  
F. Moroni ◽  
R. Recchioni
Keyword(s):  
Food Restriction ◽  
Wistar Rats ◽  
Morphometric Parameters ◽  
Female Wistar Rats
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